Cited by 782Ion channel regulation and functionCardiac electrophysiology and arrhythmiasNeuroscience and Neuropharmacology Research

Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing

Rudy, Bernardo, McBain, Chris J.·2001·Trends in Neurosciences

Abstract

Analysis of the Kv3 subfamily of K(+) channel subunits has lead to the discovery of a new class of neuronal voltage-gated K(+) channels characterized by positively shifted voltage dependencies and very fast deactivation rates. These properties are adaptations that allow these channels to produce currents that can specifically enable fast repolarization of action potentials without compromising spike initiation or height. The short spike duration and the rapid deactivation of the Kv3 currents after spike repolarization maximize the quick recovery of resting conditions after an action potential. Several neurons in the mammalian CNS have incorporated into their repertoire of voltage-dependent conductances a relatively large number of Kv3 channels to enable repetitive firing at high frequencies - an ability that crucially depends on the special properties of Kv3 channels and their impact on excitability.

Integrity signals

Registry

Crossref · 10.1016/s0166-2236(00)01892-0

Cites

75 of 75 references verified0 citation errors · 0 not checkable

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  • One set of co-expressed genes encoded proteins that enable fast and persistent action potentials, including Kcnc1-3 (Kv3.1), Kcna1 (Kv1.1) and Scn8a (Nav1.6) channels.

    “One set of co-expressed genes encoded proteins that enable fast and persistent action potentials, including the Kcnc1–3 (Kv3.1), Kcna1 (Kv1.1) and Scn8a (Nav1.6) channels”

    From Molecular diversity and specializations among the cells of the adult mouse brain (2018) · cites this paper as Rudy and McBain, 2001

  • Early attempts to match expression patterns of cloned channel transcripts with biophysical properties measured by whole cell recording in in vitro slices yielded some modest successes, particularly with channels formed by the Kv3 family.

    “Early attempts to match expression patterns of recent cloned channel transcripts with biophysical properties measured by whole cell recording techniques in in vitro slices did, however, yield some modest successes, particularly with channels formed by the Kv3 family of voltage-gated potassium channels (967) as discussed below.”

    From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [967]

  • Delayed rectifier channels assembled from Kv3 subunits are instrumental components in conferring high-frequency action potential firing in numerous hippocampal and cortical interneuron subtypes.

    “Delayed rectifier channels assembled from Kv3 subunits are instrumental components in conferring high-frequency action potential firing in numerous hippocampal and cortical interneuron subtypes (304, 967, 1187).”

    From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [967]

  • Few channels expressed in recombinant systems perfectly matched the biophysical properties of native channels.

    “This optimism was short lived as it became apparent that few channels expressed in recombinant systems perfectly matched the biophysical properties of native channels (967).”

    From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [967]

  • The rapid activation kinetics of Kv3 channels enforces a narrow temporal window that minimizes Na+ channel inactivation, and the consequent deep hyperpolarization serves to deinactivate other voltage-gated channels ensuring a high fraction are available for activation during trains of action potentials.

    “Importantly, the rapid activation kinetics enforces a narrow temporal window that minimizes Na+ channel inactivation, and the consequent deep hyperpolarization serves to deinactivate other voltage-gated channels ensuring a high fraction are available for activation during trains of action potentials (967).”

    From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [967]

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Authors
Rudy, B., & McBain, C. J.
Affiliations
  • New York University (US)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
Corresponding author
  • Rudy, Bernardo
  • McBain, Chris J.
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2001-09
Volume
24
Issue
9
Pages
517-526
ISSN
0166-2236 (ISSN-L)
OpenAlex
W2034132958
Cited by
781
References
76
Citations by year
2026: 36 · 2025: 27 · 2024: 45 · 2023: 27 · 2022: 36 · 2021: 33 · 2020: 39 · 2019: 32 · 2018: 32 · 2017: 34 · 2016: 20 · 2015: 26 · 2014: 23 · 2013: 30 · 2012: 32
FWCI
1.84
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1r01ns035215-01a1, 5r01ns030989-22)
  • National Institute of Neurological Disorders and Stroke (NS-30989, NS-35215)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
voltage-gated potassium channels, action potential repolarization, repetitive firing, neuronal excitability, spike initiation, central nervous system neurons
MeSH terms
Action Potentials, Animals, Brain, Humans, Neurons, Potassium Channels, Potassium Channels, Voltage-Gated, Shaw Potassium Channels

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