Distinct enzyme combinations in AKAP signalling complexes permit functional diversity

Initial sequencing and analysis of the human genome

International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216 · see citing works

The sequence of the human genome

Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909 · see citing works

The Sequence of the Human Genome

Venter, J., Adams, M., Myers, E., Li, P. W., Mural, R., Sutton, G., Smith, H., Yandell, M., Evans, C., Holt, R., et al. (2001) · Science · doi:10.1373/clinchem.2014.237016 · Cited by 6,779 · see citing works

Signaling—2000 and Beyond

Hunter, T. (2000) · Cell · doi:10.1016/s0092-8674(00)81688-8 · Cited by 2,586 · see citing works

Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone

Brown, D. A., & Adams, P. R. (1980) · Nature · doi:10.1038/283673a0 · Cited by 1,449 · see citing works

Assembly of Cell Regulatory Systems Through Protein Interaction Domains

Pawson, T. J., & Nash, P. (2003) · Science · doi:10.1126/science.1083653 · Cited by 1,403 · see citing works

AKAP signalling complexes: focal points in space and time

Wong, W., & Scott, J. D. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1527 · Cited by 1,073 · see citing works

PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity

Esteban, J. A., Shi, S.-H., Wilson, C., Nuriya, M., Huganir, R. L., & Malinow, R. (2003) · Nature Neuroscience · doi:10.1038/nn997 · Cited by 894 · see citing works

Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase

Banke, T. G., Bowie, D., Lee, H.-K., Huganir, R. L., Schousboe, A., & Traynelis, S. F. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00089.2000 · Cited by 652 · see citing works

Coordination of Three Signaling Enzymes by AKAP79, a Mammalian Scaffold Protein

Klauck, T. M., Faux, M. C., Labudda, K., Langeberg, L. K., Jaken, S., & Scott, J. D. (1996) · Science · doi:10.1126/science.271.5255.1589 · Cited by 550 · see citing works

PIP2 Activates KCNQ Channels, and Its Hydrolysis Underlies Receptor-Mediated Inhibition of M Currents

Zhang, H., Craciun, L. C., Mirshahi, T., Rohács, T., Lopes, C. M. B., Jin, T., & Logothetis, D. E. (2003) · Neuron · doi:10.1016/s0896-6273(03)00125-9 · Cited by 523 · see citing works

PDZ domains in synapse assembly and signalling

Garner, C. C., Nash, J. E., & Huganir, R. L. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01783-9 · Cited by 520 · see citing works

cAMP-Dependent Regulation of Cardiac L-Type Ca2+ Channels Requires Membrane Targeting of PKA and Phosphorylation of Channel Subunits

Gao, T., Yatani, A., Dell’Acqua, M. L., Sako, H., Green, S. A., Dascal, N., Scott, J. D., & Hosey, M. T. (1997) · Neuron · doi:10.1016/s0896-6273(00)80358-x · Cited by 520 · see citing works

Regulation of NMDA Receptors by an Associated Phosphatase-Kinase Signaling Complex

Westphal, R. S., Tavalin, S. J., Lin, J., Alto, N. M., Fraser, I. D. C., Langeberg, L. K., Sheng, M., & Scott, J. D. (1999) · Science · doi:10.1126/science.285.5424.93 · Cited by 495 · see citing works

Recovery from Muscarinic Modulation of M Current Channels Requires Phosphatidylinositol 4,5-Bisphosphate Synthesis

Suh, B., & Hille, B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00790-0 · Cited by 478 · see citing works

CONTROL OF M-CURRENT

Marrion, N. V. (1997) · Annual Review of Physiology · doi:10.1146/annurev.physiol.59.1.483 · Cited by 353 · see citing works

Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain.

Carr, D. W., Hausken, Z. E., Fraser, I. D. C., Stofko, R. E., & Scott, J. D. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42221-1 · Cited by 346 · see citing works

Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79.

Carr, D. W., Stofko, R. E., Fraser, I. D. C., Cone, R. D., & Scott, J. D. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41856-x · Cited by 331 · see citing works

Dopaminergic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons

Smith, W. B., Starck, S. R., Roberts, R. W., & Schuman, E. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.015 · Cited by 252 · see citing works

AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists

Hoshi, N., Zhang, J.-S., Omaki, M., Takeuchi, T., Yokoyama, S., Wanaverbecq, N., Langeberg, L. K., Yoneda, Y., Scott, J. D., Brown, D. A., et al. (2003) · Nature Neuroscience · doi:10.1038/nn1062 · Cited by 244 · see citing works

Membrane‐targeting sequences on AKAP79 bind phosphatidylinositol‐4,5‐bisphosphate

Dell’Acqua, M. L., Faux, M. C., Thorburn, J., Thorburn, A., & Scott, J. D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.8.2246 · Cited by 229 · see citing works

Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression

Tavalin, S. J., Colledge, M., Hell, J. W., Langeberg, L. K., Huganir, R. L., & Scott, J. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03044.2002 · Cited by 222 · see citing works

Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy

Cooper, E. C., Aldape, K., Abosch, A., Barbaro, N. M., Berger, M. S., Peacock, W. S., Jan, Y. N., & Jan, L. Y. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090092797 · Cited by 217 · see citing works

Bradykinin inhibits M current via phospholipase C and Ca 2+ release from IP 3 -sensitive Ca 2+ stores in rat sympathetic neurons

Cruzblanca, H., Koh, D., & Hille, B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.7151 · Cited by 179 · see citing works

Phosphorylation at Conserved Carboxyl-terminal Hydrophobic Motif Regulates the Catalytic and Regulatory Domains of Protein Kinase C

EDWARDS, A. S., & Newton, A. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.18382 · Cited by 153 · see citing works

Mapping the Protein Phosphatase-2B Anchoring Site on AKAP79

Dell’Acqua, M. L., Dodge‐Kafka, K. L., Tavalin, S. J., & Scott, J. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207833200 · Cited by 132 · see citing works

Regulation of the AKAP79-Protein Kinase C Interaction by Ca2+/Calmodulin

Faux, M. C., & Scott, J. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.17038 · Cited by 120 · see citing works

Modulation of Ion Channels

Fraser, I. D. C., & Scott, J. D. (1999) · Neuron · doi:10.1016/s0896-6273(00)80795-3 · Cited by 106 · see citing works

Protein kinase C is not necessary for peptide-induced suppression of M current or for desensitization of the peptide receptors.

Bosma, M. M., & Hille, B. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2943 · Cited by 91 · see citing works

Calcineurin Regulates M Channel Modal Gating in Sympathetic Neurons

Marrion, N. V. (1996) · Neuron · doi:10.1016/s0896-6273(00)80033-1 · Cited by 54 · see citing works

Cell Signaling in Space and Time: Where Proteins Come Together and When They’re Apart

Scott, J. D., & Pawson, T. J. (2009) · Science · doi:10.1126/science.1175668 · Cited by 648 · see citing works

Supramolecular Assemblies and Localized Regulation of Voltage-Gated Ion Channels

Dai, S., Hall, D. D., & Hell, J. W. (2009) · Physiological Reviews · doi:10.1152/physrev.00029.2007 · Cited by 330 · see citing works

AKAP79/150 Anchoring of Calcineurin Controls Neuronal L-Type Ca2+ Channel Activity and Nuclear Signaling

Oliveria, S. F., Dell'Acqua, M. L., & Sather, W. A. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.032 · Cited by 344 · see citing works

Signalling scaffolds and local organization of cellular behaviour

Langeberg, L. K., & Scott, J. D. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3966 · Cited by 271 · see citing works

Proinflammatory Mediators Modulate the Heat-Activated Ion Channel TRPV1 via the Scaffolding Protein AKAP79/150

Zhang, X., Li, L., & McNaughton, P. A. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.015 · Cited by 275 · see citing works

Adenylyl Cyclase–A-kinase Anchoring Protein Complexes: The Next Dimension in cAMP Signaling

DESSAUER, C. W. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.059345 · Cited by 254 · see citing works

Regulation of ion transport proteins by membrane phosphoinositides

Gamper, N. L., & Shapiro, M. S. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2257 · Cited by 242 · see citing works

Dynamic Regulation of cAMP Synthesis through Anchored PKA-Adenylyl Cyclase V/VI Complexes

Bauman, A. L., Soughayer, J. S., Nguyen, B. T., Willoughby, D., Carnegie, G. K., Wong, W., Hoshi, N., Langeberg, L. K., Cooper, D. M. F., DESSAUER, C. W., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.07.025 · Cited by 218 · see citing works

Local protein kinase A action proceeds through intact holoenzymes

Smith, F. D., Esseltine, J. L., Nygren, P. J., Veesler, D., Byrne, D. P., Vonderach, M., Strashnov, I., Eyers, C. E., Eyers, P. A., Langeberg, L. K., et al. (2017) · Science · doi:10.1126/science.aaj1669 · Cited by 213 · see citing works

Creating Order from Chaos: Cellular Regulation by Kinase Anchoring

Scott, J. D., DESSAUER, C. W., & Taskén, K. (2012) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140204 · Cited by 206 · see citing works

Dynamic control of signaling by modular adaptor proteins

Pawson, T. J. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.013 · Cited by 205 · see citing works

A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors

Bhattacharyya, S., Biou, V., Xu, W., Schlüter, O., & Malenka, R. C. (2009) · Nature Neuroscience · doi:10.1038/nn.2249 · Cited by 185 · see citing works

An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics

Willoughby, D., Wong, W., Schaack, J. B., Scott, J. D., & Cooper, D. M. F. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601113 · Cited by 185 · see citing works

AKAP signaling complexes in regulation of excitatory synaptic plasticity

Sanderson, J. L., & Dell'Acqua, M. L. (2011) · The Neuroscientist · doi:10.1177/1073858410384740 · Cited by 185 · see citing works

Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins

Pidoux, G., & Taskén, K. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-10-0010 · Cited by 184 · see citing works

Activation of the TRPV4 Ion Channel Is Enhanced by Phosphorylation

Fan, H., Zhang, X., & McNaughton, P. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.028803 · Cited by 182 · see citing works

Modulation of Kv7 channels and excitability in the brain

Greene, D. L., & Hoshi, N. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2359-y · Cited by 177 · see citing works

Regulation of neuronal PKA signaling through AKAP targeting dynamics

Dell’Acqua, M. L., Smith, K. E., Gorski, J. A., Horne, E. A., Gibson, E. S., & Gomez, L. L. (2006) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2006.01.010 · Cited by 173 · see citing works

Networking with AKAPs: Context-dependent Regulation of Anchored Enzymes

Welch, E. J., Jones, B. W., & Scott, J. D. (2010) · Molecular Interventions · doi:10.1124/mi.10.2.6 · Cited by 166 · see citing works

The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function

Grandoch, M., Roscioni, S. S., & Schmidt, M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00458.x · Cited by 153 · see citing works

Loss of AKAP150 perturbs distinct neuronal processes in mice

Tunquist, B. J., Hoshi, N., Guire, E. S., Zhang, F., Müllendorff, K., Langeberg, L. K., Raber, J., & Scott, J. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805922105 · Cited by 154 · see citing works

AKAP-Anchored PKA Maintains Neuronal L-type Calcium Channel Activity and NFAT Transcriptional Signaling

Murphy, J. G., Sanderson, J. L., Gorski, J. A., Scott, J. D., Catterall, W. A., Sather, W. A., & Dell’Acqua, M. L. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.027 · Cited by 148 · see citing works

A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1

Jeske, N. A., Diogenes, A. R., Ruparel, N. B., Fehrenbacher, J. C., Henry, M. A., Akopian, A. N., & Hargreaves, K. (2008) · Pain · doi:10.1016/j.pain.2008.02.022 · Cited by 142 · see citing works

Balanced interactions of calcineurin with AKAP79 regulate Ca2+–calcineurin–NFAT signaling

Li, H., Pink, M. D., Murphy, J. G., Stein, A., Dell’Acqua, M. L., & Hogan, P. G. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2238 · Cited by 142 · see citing works

The where's and when's of kinase anchoring

Smith, F. D., Langeberg, L. K., & Scott, J. D. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.04.009 · Cited by 139 · see citing works

AKAP150-Anchored Calcineurin Regulates Synaptic Plasticity by Limiting Synaptic Incorporation of Ca²⁺-Permeable AMPA Receptors

Sanderson, J. L., Gorski, J. A., Gibson, E. S., Lam, P., Freund, R. K., Chick, W. S., & Dell'Acqua, M. L. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3326-12.2012 · Cited by 137 · see citing works

Subcellular Dynamics of Type II PKA in Neurons

Zhong, H., Sia, G.-M., Sato, T., Gray, N. W., Mao, T., Khuchua, Z. A., Huganir, R. L., & Svoboda, K. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.013 · Cited by 125 · see citing works

AKAP Signaling Islands: Venues for Precision Pharmacology

Omar, M. H., & Scott, J. D. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.09.007 · Cited by 123 · see citing works

Inhibition of M Current in Sensory Neurons by Exogenous Proteases: A Signaling Pathway Mediating Inflammatory Nociception

Linley, J. E., Rose, K. E., Patil, M. J., Robertson, B., Akopian, A. N., & Gamper, N. L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2297-08.2008 · Cited by 121 · see citing works

Phosphorylation-Dependent Regulation of Ca2+-Permeable AMPA Receptors During Hippocampal Synaptic Plasticity

Purkey, A., & Dell’Acqua, M. L. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00008 · Cited by 113 · see citing works

Ser 1928 phosphorylation by PKA stimulates the L-type Ca 2+ channel Ca V 1.2 and vasoconstriction during acute hyperglycemia and diabetes

Nystoriak, M. A., Nieves‐Cintrón, M., Patriarchi, T., Buonarati, O. R., Prada, M. P., Morotti, S., Grandi, E., Fernandes, J. D. S., Forbush, K. A., Hofmann, F. B., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aaf9647 · Cited by 117 · see citing works

Calcineurin mediates synaptic scaling via synaptic trafficking of Ca2+-permeable AMPA receptors

Kim, S., & Ziff, E. B. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001900 · Cited by 114 · see citing works

Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-κB transcription factors

Round, J. L., Humphries, L. A., Tomassian, T., Mittelstadt, P. R., Zhang, M., & Miceli, M. C. (2006) · Nature Immunology · doi:10.1038/ni1422 · Cited by 113 · see citing works

T-cell receptor ligation induces distinct signaling pathways in naïve vs. antigen-experienced T cells

Adachi, K., & Davis, M. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017340108 · Cited by 111 · see citing works

AKAP79 Interacts with Multiple Adenylyl Cyclase (AC) Isoforms and Scaffolds AC5 and -6 to α-Amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) Receptors

Efendiev, R., Samelson, B. K., Nguyen, B. T., Phatarpekar, P. V., Baameur, F., Scott, J. D., & DESSAUER, C. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.109769 · Cited by 111 · see citing works

Interaction with AKAP79 Modifies the Cellular Pharmacology of PKC

Hoshi, N., Langeberg, L. K., Gould, C. M., Newton, A. C., & Scott, J. D. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.014 · Cited by 110 · see citing works

Palmitoylation of A-Kinase Anchoring Protein 79/150 Regulates Dendritic Endosomal Targeting and Synaptic Plasticity Mechanisms

Keith, D. J., Sanderson, J. L., Gibson, E. S., Woolfrey, K. M., Robertson, H. R., Olszewski, K., Kang, R., El-Husseini, A., & Dell'Acqua, M. L. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0784-12.2012 · Cited by 108 · see citing works

Functional Consequences of Mutations in Postsynaptic Scaffolding Proteins and Relevance to Psychiatric Disorders

Ting, J. T., Peça, J., & Feng, G. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150442 · Cited by 106 · see citing works

Phospholipase C Is Required for Changes in Postsynaptic Structure and Function Associated with NMDA Receptor-Dependent Long-Term Depression

Horne, E. A., & Dell’Acqua, M. L. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4340-06.2007 · Cited by 107 · see citing works

A calcineurin/AKAP complex is required for NMDA receptor-dependent long-term depression

Jurado, S., Biou, V., & Malenka, R. C. (2010) · Nature Neuroscience · doi:10.1038/nn.2613 · Cited by 101 · see citing works

Elevated Ca2+sparklet activity during acute hyperglycemia and diabetes in cerebral arterial smooth muscle cells

Navedo, M. F., Takeda, Y., Nieves‐Cintrón, M., Molkentin, J. D., & Santana, L. F. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00267.2009 · Cited by 100 · see citing works

Regulation of M(Kv7.2/7.3) channels in neurons by PIP2and products of PIP2hydrolysis: significance for receptor‐mediated inhibition

Brown, D. A., Hughes, S. A., Marsh, S. J., & Tinker, A. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.132498 · Cited by 95 · see citing works

Coordinated signal integration at the M‐type potassium channel upon muscarinic stimulation

Kosenko, A., Kang, S., Smith, I. M., Greene, D. L., Langeberg, L. K., Scott, J. D., & Hoshi, N. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.156 · Cited by 87 · see citing works

Tissue kallikrein stimulates Ca2+ reabsorption via PKC‐dependent plasma membrane accumulation of TRPV5

Gkika, D., Topala, C. N., Qing, C., Picard, N., Thébault, S. C., Houillier, P., Hoenderop, J. G. J., & Bindels, R. J. M. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601357 · Cited by 85 · see citing works

Clustering and Functional Coupling of Diverse Ion Channels and Signaling Proteins Revealed by Super-resolution STORM Microscopy in Neurons

Zhang, J., Carver, C. M., Choveau, F. S., & Shapiro, M. S. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.014 · Cited by 84 · see citing works

Activity-Dependent Transcriptional Regulation of M-Type (Kv7) K+ Channels by AKAP79/150-Mediated NFAT Actions

Zhang, J., & Shapiro, M. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.019 · Cited by 81 · see citing works

A-Kinase Anchoring Proteins

Scott, J. D., & Santana, L. F. (2010) · Circulation · doi:10.1161/circulationaha.109.896357 · Cited by 79 · see citing works

Sub‐picomolar relaxin signalling by a pre‐assembled RXFP1, AKAP79, AC2, β‐arrestin 2, PDE4D3 complex

Halls, M. L., & Cooper, D. M. F. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.168 · Cited by 79 · see citing works

Spatiotemporal control of cAMP signalling processes by anchored signalling complexes

Jarnæss, E., & Taskén, K. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350931 · Cited by 76 · see citing works

Control of Homeostatic Synaptic Plasticity by AKAP-Anchored Kinase and Phosphatase Regulation of Ca 2+ -Permeable AMPA Receptors

Sanderson, J. L., Scott, J. D., & Dell’Acqua, M. L. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2362-17.2018 · Cited by 75 · see citing works

Synapse-to-Nucleus Communication through NFAT Is Mediated by L-type Ca2+ Channel Ca2+ Spike Propagation to the Soma

Wild, A. R., Sinnen, B. L., Dittmer, P. J., Kennedy, M. J., Sather, W. A., & Dell’Acqua, M. L. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.005 · Cited by 73 · see citing works

Anchored phosphatases modulate glucose homeostasis

Hinke, S. A., Navedo, M. F., Ulman, A., Whiting, J. L., Nygren, P. J., Tian, G., Jiménez‐Caliani, A. J., Langeberg, L. K., Cirulli, V., Tengholm, A., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.244 · Cited by 72 · see citing works

Homomeric and Heteromeric Assembly of KCNQ (Kv7) K+ Channels Assayed by Total Internal Reflection Fluorescence/Fluorescence Resonance Energy Transfer and Patch Clamp Analysis

Bal, M., Zhang, J., Zaika, O., Hernández, C. C., & Shapiro, M. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805216200 · Cited by 69 · see citing works

Potential for therapeutic targeting of AKAP signaling complexes in nervous system disorders

Wild, A. R., & Dell’Acqua, M. L. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.12.004 · Cited by 66 · see citing works

Postsynaptic localization and regulation of AMPA receptors and Cav1.2 by β2 adrenergic receptor/PKA and Ca2+/CaMKII signaling

Patriarchi, T., Buonarati, O. R., & Hell, J. W. (2018) · The EMBO Journal · doi:10.15252/embj.201899771 · Cited by 65 · see citing works

Ca2+/Calmodulin Disrupts AKAP79/150 Interactions with KCNQ (M-Type) K+Channels

Bal, M., Zhang, J., Hernández, C. C., Zaika, O., & Shapiro, M. S. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5175-09.2010 · Cited by 69 · see citing works

In Search of Analgesia: Emerging Poles of GPCRs in Pain

Stone, L. S., & Molliver, D. C. (2009) · Molecular Interventions · doi:10.1124/mi.9.5.7 · Cited by 68 · see citing works

Regulation of Postsynaptic Structure and Function by an A-Kinase Anchoring Protein-Membrane-Associated Guanylate Kinase Scaffolding Complex

Robertson, H. R., Gibson, E. S., Benke, T. A., & Dell’Acqua, M. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6093-08.2009 · Cited by 68 · see citing works

Neuromodulatory Effect of Gαs- or Gαq-Coupled G-Protein-Coupled Receptor on NMDA Receptor Selectively Activates the NMDA Receptor/Ca2+/Calcineurin/cAMP Response Element-Binding Protein-Regulated Transcriptional Coactivator 1 Pathway to Effectively Induce Brain-Derived Neurotrophic Factor Expression in Neurons

Fukuchi, M., Tabuchi, A., Kuwana, Y., Watanabe, S., Inoue, M., Takasaki, I., Izumi, H., Tanaka, A., Inoue, R., Mori, H., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3650-14.2015 · Cited by 66 · see citing works

Adenylyl Cyclase Anchoring by a Kinase Anchor Protein AKAP5 (AKAP79/150) Is Important for Postsynaptic β-Adrenergic Signaling

Zhang, M., Patriarchi, T., Stein, I. S., Qian, H., Matt, L., Nguyen, M., Xiang, Y. K., & Hell, J. W. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.449462 · Cited by 66 · see citing works

mAKAP Compartmentalizes Oxygen-Dependent Control of HIF-1α

Wong, W., Goehring, A. S., Kapiloff, M. S., Langeberg, L. K., & Scott, J. D. (2008) · Science Signaling · doi:10.1126/scisignal.2000026 · Cited by 63 · see citing works

Signal integration through blending, bolstering and bifurcating of intracellular information

Pawson, C. T., & Scott, J. D. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1843 · Cited by 60 · see citing works

Localized Calcineurin Confers Ca 2+ -Dependent Inactivation on Neuronal L-Type Ca 2+ Channels

Oliveria, S. F., Dittmer, P. J., Youn, D., Dell’Acqua, M. L., & Sather, W. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2302-12.2012 · Cited by 61 · see citing works

A Change in Configuration of the Calmodulin-KCNQ Channel Complex Underlies Ca2+-Dependent Modulation of KCNQ Channel Activity

Kosenko, A., & Hoshi, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082290 · Cited by 61 · see citing works

STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs

García-Alvarez, G., Lu, B., Yap, K. A. F., Wong, L. C., Thevathasan, J. V., Lim, L., Ji, F., Tan, K. W., Mancuso, J. J., Tang, W., et al. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-07-1222 · Cited by 59 · see citing works

Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels

van der Horst, J., Greenwood, I. A., & Jepps, T. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00727 · Cited by 60 · see citing works

Drugs That Regulate Local Cell Signaling: AKAP Targeting as a Therapeutic Option

Bucko, P. J., & Scott, J. D. (2020) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-022420-112134 · Cited by 57 · see citing works

Spatially compartmentalized phase regulation of a Ca2+-cAMP-PKA oscillatory circuit

Tenner, B., Getz, M., Ross, B. L., Ohadi, D., Bohrer, C. H., Greenwald, E. C., Mehta, S., Xiao, J., Rangamani, P., & Zhang, J. (2020) · eLife · doi:10.7554/elife.55013 · Cited by 55 · see citing works

AKAP79/150 Signal Complexes in G-Protein Modulation of Neuronal Ion Channels

Zhang, J., Bal, M., Bierbower, S. M., Zaika, O., & Shapiro, M. S. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4446-10.2011 · Cited by 57 · see citing works

Proteomic approaches to the analysis of multiprotein signaling complexes

Yang, W., Steen, H., & Freeman, M. R. (2008) · PROTEOMICS · doi:10.1002/pmic.200700650 · Cited by 54 · see citing works

Review: Spatiotemporal dynamics of hCG/cAMP signaling and regulation of placental function

Weedon-Fekjær, M. S., & Taskén, K. (2011) · Placenta · doi:10.1016/j.placenta.2011.11.003 · Cited by 54 · see citing works

AKAP79/150 Impacts Intrinsic Excitability of Hippocampal Neurons through Phospho-Regulation of A-type K+Channel Trafficking

Lin, L., Sun, W., Kung, F., Dell’Acqua, M. L., & Hoffman, D. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5383-10.2011 · Cited by 54 · see citing works

Ca2+/Calmodulin-dependent Protein Kinase II Binds to and Phosphorylates a Specific SAP97 Splice Variant to Disrupt Association with AKAP79/150 and Modulate α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid-type Glutamate Receptor (AMPAR) Activity

Nikandrova, Y., Jiao, Y., Baucum, A. J., Tavalin, S. J., & Colbran, R. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.033985 · Cited by 53 · see citing works

PKC phosphorylates GluA1-Ser831 to enhance AMPA receptor conductance

Jenkins, M. A., & Traynelis, S. F. (2012) · Channels · doi:10.4161/chan.18648 · Cited by 52 · see citing works

Structural basis for cholinergic regulation of neural circuits in the mouse olfactory bulb

Hamamoto, M., Kiyokage, E., Sohn, J., Hioki, H., Harada, T., & Toida, K. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24088 · Cited by 52 · see citing works

Organizing signal transduction through A‐kinase anchoring proteins (AKAPs)

Logue, J. S., & Scott, J. D. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07866.x · Cited by 51 · see citing works

AKAP79 Selectively Enhances Protein Kinase C Regulation of GluR1 at a Ca2+-Calmodulin-dependent Protein Kinase II/Protein Kinase C Site

Tavalin, S. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709253200 · Cited by 51 · see citing works

M-current preservation contributes to anticonvulsant effects of valproic acid

Kay, H. Y., Greene, D. L., Kang, S., Kosenko, A., & Hoshi, N. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79727 · Cited by 50 · see citing works

A-kinase anchoring protein 150 in the mouse brain is concentrated in areas involved in learning and memory

Ostroveanu, A., van der Zee, E. A., Dolga, A. M., Luiten, P. G. M., Eisel, U. L. M., & Nijholt, I. M. (2007) · Brain Research · doi:10.1016/j.brainres.2007.01.117 · Cited by 49 · see citing works

Compartmentalization of GPCR signalling controls unique cellular responses

Ellisdon, A. M., & Halls, M. L. (2016) · Biochemical Society Transactions · doi:10.1042/bst20150236 · Cited by 49 · see citing works

MyRIP Anchors Protein Kinase A to the Exocyst Complex

Goehring, A. S., Pedroja, B. S., Hinke, S. A., Langeberg, L. K., & Scott, J. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705167200 · Cited by 48 · see citing works

AKAP79/150 recruits the transcription factor NFAT to regulate signaling to the nucleus by neuronal L-type Ca2+channels

Murphy, J. G., Crosby, K. C., Dittmer, P. J., Sather, W. A., & Dell’Acqua, M. L. (2019) · Molecular Biology of the Cell · doi:10.1091/mbc.e19-01-0060 · Cited by 46 · see citing works

Calmodulin binding to M‐type K+channels assayed by TIRF/FRET in living cells

Bal, M., Zaika, O., Martin, P., & Shapiro, M. S. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.152777 · Cited by 45 · see citing works

G-protein-coupled receptor-associated A-kinase anchoring proteins AKAP5 and AKAP12: differential signaling to MAPK and GPCR recycling

Tao, J., & Malbon, C. C. (2008) · Journal of Molecular Signaling · doi:10.1186/1750-2187-3-19 · Cited by 43 · see citing works

AKAP150 involved in paclitaxel-induced neuropathic pain via inhibiting CN/NFAT2 pathway and downregulating IL-4

Nie, B., Liu, C., Bai, X., Chen, X. F., Wu, S., Zhang, S., Huang, Z., Xie, M.-X., Xu, T., Xin, W., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.10.015 · Cited by 42 · see citing works

PP2B/calcineurin-mediated desensitization of TRPV1 does not require AKAP150

Por, E. D., Samelson, B. K., Belugin, S., Akopian, A. N., Scott, J. D., & Jeske, N. A. (2010) · Biochemical Journal · doi:10.1042/bj20100936 · Cited by 41 · see citing works

A ‐kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases

Poppinga, W. J., Muñoz-LLancao, P., González-Billault, C. E., & Schmidt, M. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12882 · Cited by 41 · see citing works

G-protein-coupled receptor-associated A-kinase anchoring proteins: AKAP79 and AKAP250 (gravin)

Wang, H., Tao, J., Shumay, E., & Malbon, C. C. (2006) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2005.12.003 · Cited by 40 · see citing works

Anchored cAMP signaling: Onward and upward – A short history of compartmentalized cAMP signal transduction

Smith, F. D., & Scott, J. D. (2006) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2006.01.011 · Cited by 39 · see citing works

Kv7 Channels and Excitability Disorders

Jones, F., Gamper, N., & Gao, H. (2021) · Handbook of Experimental Pharmacology · doi:10.1007/164_2021_457 · Cited by 38 · see citing works

Signaling at A-Kinase Anchoring Proteins Organizes Anesthesia-Sensitive Memory inDrosophila

Schwärzel, M., Jaeckel, A., & Mueller, U. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4622-06.2007 · Cited by 37 · see citing works

Regulation of excitability by potassium channels

Pongs, O. (2007) · Results and Problems in Cell Differentiation · doi:10.1007/400_2007_032 · Cited by 37 · see citing works

Preassembled GPCR signaling complexes mediate distinct cellular responses to ultralow ligand concentrations

Civciristov, S., Ellisdon, A. M., Suderman, R., Pon, C. K., Evans, B. A., Kleifeld, O., Charlton, S. J., Hlavacek, W. S., Canals, M., & Halls, M. L. (2018) · Science Signaling · doi:10.1126/scisignal.aan1188 · Cited by 35 · see citing works

Anchoring protein AKAP79‐mediated PKA phosphorylation of STIM1 determines selective activation of the ARC channel, a store‐independent Orai channel

Thompson, J. L., & Shuttleworth, T. J. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.284182 · Cited by 35 · see citing works

Reduced axonal surface expression and phosphoinositide sensitivity in K v 7 channels disrupts their function to inhibit neuronal excitability in Kcnq2 epileptic encephalopathy

Kim, E. C., Zhang, J., Pang, W., Wang, S., Lee, K. Y., Cavaretta, J. P., Walters, J. M., Procko, E., Tsai, N., & Chung, H. J. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.07.004 · Cited by 35 · see citing works

A-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation

Brackley, A. D., Gómez, R. S., Dietert, K., Akopian, A. N., Glucksman, M., Du, J., Carlton, S. M., & Jeske, N. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-01999-4 · Cited by 32 · see citing works

Gq-coupled muscarinic receptor enhancement of KCNQ2/3 channels and activation of TRPC channels in multimodal control of excitability in dentate gyrus granule cells

Carver, C. M., & Shapiro, M. S. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1781-18.2018 · Cited by 31 · see citing works

Direct AKAP-Mediated Protein-Protein Interactions as Potential Drug Targets

Hundsrucker, C., & Klußmann, E. (2008) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-72843-6_20 · Cited by 32 · see citing works

Attenuating M‐current suppression in vivo by a mutantKcnq2gene knock‐in reduces seizure burden and prevents status epilepticus–induced neuronal death and epileptogenesis

Greene, D. L., Kosenko, A., & Hoshi, N. (2018) · Epilepsia · doi:10.1111/epi.14541 · Cited by 31 · see citing works

β-Adrenergic Regulation of the L-Type Ca 2+ Channel Ca V 1.2 by PKA Rekindles Excitement

Hell, J. W. (2010) · Science Signaling · doi:10.1126/scisignal.3141pe33 · Cited by 29 · see citing works

Contextual utilization of enzymes in discrete AKAP79/150 signalling complexes

Hoshi, N., & Scott, J. D. (2006) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2006.01.004 · Cited by 3 · see citing works

AKAP Regulates Different Channels Through Different Enzymes

(2005) · Science s STKE · doi:10.1126/stke.3092005tw392

A-kinase anchoring proteins: different partners, different dance

Chen, L., & Kass, R. S. (2005) · Nature Cell Biology · doi:10.1038/ncb1105-1050 · Cited by 22 · see citing works

Mechanisms and dynamics of AKAP79/150‐orchestrated multi‐protein signalling complexes in brain and peripheral nerve

Zhang, J., & Shapiro, M. S. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.287698 · Cited by 15 · see citing works

AKAP Transduction Units

Scott, J. D., & Langeberg, L. K. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00166-2