Transcriptional Control of Regulatory T cells
Abstract
Regulatory T cells (Tregs) constitute unique T cell lineage that plays a key role for immunological tolerance. Tregs are characterized by the expression of the forkhead box transcription factor Foxp3, which acts as a lineage-specifying factor by determining the unique suppression profile of these immune cells. Here, we summarize the recent progress in understanding how Foxp3 expression itself is epigenetically and transcriptionally controlled, how the Treg-specific signature is achieved and how unique properties of Treg subsets are defined by other transcription factors. Finally, we will discuss recent studies focusing on the molecular targeting of Tregs to utilize the specific properties of this unique cell type in therapeutic settings.
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Co-expression of Foxp3 and a second Th-lineage-defining transcription factor, such as T-bet and Gata-3, enables Treg cells to specifically suppress the respective Th-mediated immune response.
“Co-expression of Foxp3 and a second Th-lineage-defining transcription factor, such as T-bet and Gata-3, enables Treg cells to specifically suppress the respective Th-mediated immune response [441].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [441]
Cites
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“A key musclespecific transcription factor has yet to be identified, but gene expression comparisons revealed a number of candidate TF (Burzyn et al. 2013).”
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“For example, Foxp3 expression at low levels can be observed in activated Tconv of mice and human origin without conferring a Treg phenotype (Allan et al. 2007; Miyara et al. 2009; Miyao et al. 2012).”
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“2013), a process that has recently been described to represent the initiating step of active DNA demethylation in mammalian cells (Branco et al. 2012).”
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The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR
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Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531 · see citing works
Self-citationDelacher, M., Barra, M. M., Herzig, Y., Eichelbaum, K., Rafiee, M.-R., Richards, D. M., Träger, U., Hofer, A.-C., Kazakov, A., Braband, K. L., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101127 · Cited by 11 · see citing works
Self-citation
- Authors
- Delacher, M., Schreiber, L., Richards, D. M., Farah, C., Feuerer, M., & Huehn, J.
- Affiliations
- German Cancer Research Center (DE)
- Helmholtz Centre for Infection Research (DE)
- Corresponding author
- Feuerer, Markus
- Venue
- Current Topics in Microbiology and Immunology
- Publisher
- Springer International Publishing
- Published
- 2014
- Volume
- 381
- Pages
- 83-124
- ISSN
- 0070-217X (ISSN-L)
- 2196-9965
- OpenAlex
- W2231677677
- Cited by
- 19
- References
- 11
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 1
- FWCI
- 5.43
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- Locations
- Current topics in microbiology and immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- regulatory T cells, Foxp3, transcriptional regulation, epigenetic regulation, immune tolerance, Treg subsets, transcription factors, Treg-targeted therapy, T cell lineage specification
- MeSH terms
- Animals, Cell Differentiation, Humans, Transcription Factors, Transcription, Genetic, Signal Transduction, T-Lymphocytes, Regulatory
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