Phenotypically distinct subsets of CD4 + T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745 · see citing works

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Park, J., Adoro, S., Guinter, T. I., Erman, B., Alag, A., Catálfamo, M., Kimura, M. Y., Cui, Y., Lucas, P. J., Gress, R. E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1840 · Cited by 5,835 · see citing works

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549 · see citing works

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T _reg Cell Homeostasis

Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

Groux, H., O’Garra, A., Bigler, M., Rouleau, M., Antonenko, S. V., de Vries, J. E., & Roncarolo, M. G. (1997) · Nature · doi:10.1038/39614 · Cited by 3,588 · see citing works

N aturally A rising CD4+R egulatory T C ells for I mmunologic S elf -T olerance and N egative C ontrol of I mmune R esponses

Sakaguchi, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141122 · Cited by 3,293 · see citing works

A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease

Targan, S. R., Hanauer, S. B., van Deventer, S. J. H., Mayer, L., Present, D. H., Braakman, T., DeWoody, K. L., Schaible, T. F., & Rutgeerts, P. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199710093371502 · Cited by 3,135 · see citing works

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708 · see citing works

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

Thornton, A. M., & Shevach, E. M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.287 · Cited by 2,637 · see citing works

Role of the gut microbiota in immunity and inflammatory disease

Kamada, N., Seo, S.-U., Chen, G. Y., & Núñez, G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3430 · Cited by 2,256 · see citing works

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

Read, S., Malmström, V., & Powrie, F. M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.295 · Cited by 2,206 · see citing works

Inflammatory bowel disease: Etiology and pathogenesis

Fiocchi, C. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70381-6 · Cited by 2,059 · see citing works

Regulatory T Cells

Sakaguchi, S. (2000) · Cell · doi:10.1016/s0092-8674(00)80856-9 · Cited by 1,812 · see citing works

Inflammatory bowel disease

Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806 · see citing works

The immunological and genetic basis of inflammatory bowel disease

Bouma, G., & Strober, W. (2003) · Nature reviews. Immunology · doi:10.1038/nri1132 · Cited by 1,882 · see citing works

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

Asseman, C., Mauze, S., Leach, M. W., Coffman, R. L., & Powrie, F. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.7.995 · Cited by 1,617 · see citing works

Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β

Nakamura, K., Kitani, A., & Strober, W. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.5.629 · Cited by 1,596 · see citing works

Regulatory T cells in transplantation tolerance

Wood, K. J., & Sakaguchi, S. (2003) · Nature reviews. Immunology · doi:10.1038/nri1027 · Cited by 1,318 · see citing works

The Immunology of Mucosal Models of Inflammation

Strober, W., Fuss, I. J., & Blumberg, R. S. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064816 · Cited by 1,300 · see citing works

Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific

Thornton, A. M., & Shevach, E. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.1.183 · Cited by 1,229 · see citing works

Regulatory T Cells in Autoimmmunity

Shevach, E. M. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.423 · Cited by 1,236 · see citing works

Experimental models of inflammatory bowel disease

Elson, C. O., Sartor, R. B., Tennyson, G. S., & Riddell, R. H. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90599-5 · Cited by 1,212 · see citing works

Regulatory T cells in the control of immune pathology

Maloy, K. J., & Powrie, F. M. (2001) · Nature Immunology · doi:10.1038/ni0901-816 · Cited by 1,177 · see citing works

Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans

Roncarolo, M. G., Gregori, S., Battaglia, M., Bacchetta, R., Fleischhauer, K., & Levings, M. K. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00420.x · Cited by 1,174 · see citing works

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

Powrie, F., Leach, M. W., Mauze, S., Menon, S., Barcomb Caddle, L., & Coffman, R. L. (1994) · Immunity · doi:10.1016/1074-7613(94)90045-0 · Cited by 1,146 · see citing works

Late Developmental Plasticity in the T Helper 17 Lineage

Lee, Y. K., Turner, H., Maynard, C. L., Oliver, J. R., Chen, D., Elson, C. O., & Weaver, C. T. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.005 · Cited by 1,053 · see citing works

Interleukin-10 Therapy—Review of a New Approach

Asadullah, K., Sterry, W., & Volk, H. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.4 · Cited by 941 · see citing works

Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells

Mottet, C., Uhlig, H. H., & Powrie, F. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.3939 · Cited by 928 · see citing works

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

Powrie, F. M., Carlino, J. A., Leach, M. W., Mauze, S., & Coffman, R. L. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2669 · Cited by 894 · see citing works

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

Murai, M., Turovskaya, O., Kim, G., Madan, R., Karp, C. L., Cheroutre, H., & Kronenberg, M. (2009) · Nature Immunology · doi:10.1038/ni.1791 · Cited by 851 · see citing works

Interleukin-23 drives innate and T cell–mediated intestinal inflammation

Hue, S., Ahern, P., Buonocore, S., Kullberg, M. C., Cua, D. J., McKenzie, B. S., Powrie, F., & Maloy, K. J. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061099 · Cited by 823 · see citing works

A guide to histomorphological evaluation of intestinal inflammation in mouse models.

Erben, U., Loddenkemper, C., Doerfel, K., Spieckermann, S., Haller, D., Heimesaat, M. M., Zeitz, M., Siegmund, B., & Kühl, A. A. (2014) · Europe PMC (PubMed Central) · Cited by 768 · see citing works

IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo

Hara, M., Kingsley, C. I., Niimi, M., Read, S., Turvey, S. E., Bushell, A., Morris, P. J., Powrie, F. M., & Wood, K. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.6.3789 · Cited by 765 · see citing works

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

Ohkura, N., Hamaguchi, M., Morikawa, H., Sugimura, K., Tanaka, A., Ito, Y., Osaki, M., Tanaka, Y., Yamashita, R., Nakano, N., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.010 · Cited by 756 · see citing works

Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease

Friedrich, M., Pohin, M., & Powrie, F. M. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.017 · Cited by 750 · see citing works

Ly6Chi Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells

Zigmond, E., Varol, C., Farache, J., Elmaliah, E., Satpathy, A. T., Friedlander, G., Mack, M., Shpigel, N. Y., Boneca, I. G., MURPHY, K. M. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.08.026 · Cited by 754 · see citing works

CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms

Maloy, K. J., Salaün, L., Cahill, R., Dougan, G., Saunders, N. J. S. G., & Powrie, F. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021345 · Cited by 740 · see citing works

Cell Biology of Tight Junction Barrier Regulation and Mucosal DiseasePreprint

Buckley, A., & Turner, J. R. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a029314 · Cited by 725 · see citing works

Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors

Hsieh, C., Liang, Y., Tyznik, A. J., Self, S. G., Liggitt, D., & Rudensky, A. Y. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.009 · Cited by 719 · see citing works

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

Huang, Y.-H., Zhu, C., Kondo, Y., Anderson, A. C., Gandhi, A., Russell, A., Dougan, S. K., Petersen, B.-S., Melum, E., Pertel, T., et al. (2015) · Nature · doi:10.1038/nature13848 · Cited by 717 · see citing works

Experimental Models of Inflammatory Bowel Diseases

Kiesler, P., Fuss, I. J., & Strober, W. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.01.006 · Cited by 719 · see citing works

Cutting Edge: Control of CD8+ T Cell Activation by CD4+CD25+ Immunoregulatory Cells

Piccirillo, C. A., & Shevach, E. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.3.1137 · Cited by 716 · see citing works

Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system

Cantorna, M. T., Zhu, Y., Froicu, M., & Wittke, A. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.6.1717s · Cited by 703 · see citing works

Homeostatic expansion of T cells during immune insufficiency generates autoimmunity.

King, C., Ilic, A., Koelsch, K., & Sarvetnick, N. (2004) · Cell · doi:10.1016/s0092-8674(04)00335-6 · Cited by 747 · see citing works

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

Powrie, F., Correa-Oliveira, R., Mauze, S., & Coffman, R. L. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.2.589 · Cited by 613 · see citing works

Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

Ng, W., Duggan, P. J., Ponchel, F., Matarese, G., Lombardi, G., Edwards, A. D., Isaacs, J. D., & Lechler, R. I. (2001) · Blood · doi:10.1182/blood.v98.9.2736 · Cited by 606 · see citing works

Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10

Maynard, C. L., Harrington, L. E., Janowski, K. M., Oliver, J. R., Zindl, C. L., Rudensky, A. Y., & Weaver, C. T. (2007) · Nature Immunology · doi:10.1038/ni1504 · Cited by 599 · see citing works

Review article: yeast as probiotics – <i>Saccharomyces boulardii</i>

CZERUCKA, D., PICHE, T., & RAMPAL, P. (2007) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/j.1365-2036.2007.03442.x · Cited by 587 · see citing works

A Case for Regulatory B Cells

Mizoguchi, A., & Bhan, A. K. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.2.705 · Cited by 580 · see citing works

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+ Th17 cells

Coccia, M., Harrison, O. J., Schiering, C., Asquith, M. J., Becher, B., Powrie, F. M., & Maloy, K. J. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111453 · Cited by 588 · see citing works

Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter

Wan, Y. Y., & Flavell, R. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501701102 · Cited by 568 · see citing works

Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice

Britton, G. J., Contijoch, E. J., Mogno, I., Vennaro, O. H., Llewellyn, S. R., Ng, R., Li, Z., Mortha, A., Merad, M., Das, A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.015 · Cited by 549 · see citing works

A Novel Model of Inflammatory Bowel Disease: Mice Deficient for the Multiple Drug Resistance Gene, mdr1a, Spontaneously Develop Colitis

Panwala, C. M., Jones, J. C., & Viney, J. L. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.10.5733 · Cited by 567 · see citing works

CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10

Annacker, O., Pimenta‐Araujo, R., Burlen‐Defranoux, O., Barbosa, T., Cumano, A., & Bandeira, A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.5.3008 · Cited by 553 · see citing works

Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon

Rivollier, A., He, J., Kole, A., Valatas, V., & Kelsall, B. L. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20101387 · Cited by 548 · see citing works

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

Hsieh, C., Zheng, Y., Liang, Y., Fontenot, J. D., & Rudensky, A. Y. (2006) · Nature Immunology · doi:10.1038/ni1318 · Cited by 540 · see citing works

Interleukin-10 Signaling Blocks Inhibitor of κB Kinase Activity and Nuclear Factor κB DNA Binding

Schottelius, A. J. G., Mayo, M. W., Sartor, R. B., & Baldwin, A. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.31868 · Cited by 526 · see citing works

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

Ahern, P. P., Schiering, C., Buonocore, S., McGeachy, M. J., Cua, D. J., Maloy, K. J., & Powrie, F. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.010 · Cited by 528 · see citing works

T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells

Fahlén, L., Read, S., Gorelik, L., Hurst, S. D., Coffman, R. L., Flavell, R. A., & Powrie, F. M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20040685 · Cited by 516 · see citing works

Mouse models of inflammatory bowel disease☆

Wirtz, S. J., & Neurath, M. F. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.07.003 · Cited by 508 · see citing works

T cell receptor signalling in the control of regulatory T cell differentiation and function

Li, M. O., & Rudensky, A. Y. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.26 · Cited by 493 · see citing works

The anatomical basis of intestinal immunity

Mowat, A. M., & Viney, J. L. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb00966.x · Cited by 493 · see citing works

Essential role for CD103 in the T cell–mediated regulation of experimental colitis

Annacker, O., Coombes, J. L., Malmström, V., Uhlig, H. H., Bourne, T., Johansson‐Lindbom, B., Agace, W. W., Parker, C. M., & Powrie, F. M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20040662 · Cited by 483 · see citing works

Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation

Ízcue, A., Coombes, J. L., & Powrie, F. M. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00423.x · Cited by 473 · see citing works

Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota

Elson, C. O., Cong, Y., McCracken, V. J., Dimmitt, R. A., Lorenz, R. G., & Weaver, C. T. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00291.x · Cited by 469 · see citing works

An Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells

Wang, Y., Su, M. A., & Wan, Y. Y. (2011) · Immunity · doi:10.1016/j.immuni.2011.08.012 · Cited by 461 · see citing works

Helicobacter hepaticus Triggers Colitis in Specific-Pathogen-Free Interleukin-10 (IL-10)-Deficient Mice through an IL-12- and Gamma Interferon-Dependent Mechanism

Kullberg, M. C., Ward, J. M., Gorelick, P. L., Caspar, P., Hieny, S. E., Cheever, A. W., Jankovic, D. L., & Sher, A. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5157-5166.1998 · Cited by 456 · see citing works

Expression of the integrin α E β 7 identifies unique subsets of CD25 + as well as CD25 − regulatory T cells

Lehmann, J., Huehn, J., de la Rosa, M., Maszyna, F., Kretschmer, U., Krenn, V., Brunner-Weinzierl, M. C., Scheffold, A., & Hamann, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192162899 · Cited by 454 · see citing works

CD4+ Tregs and immune control

Fehervari, Z. T., & Sakaguchi, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci23395 · Cited by 451 · see citing works

Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis

Kawanishi, S., Hiraku, Y., Pinlaor, S., & Ma, N. (2006) · Biological Chemistry · doi:10.1515/bc.2006.049 · Cited by 450 · see citing works

Principles of regulatory T cell function

Dikiy, S., & Rudensky, A. Y. (2023) · Immunity · doi:10.1016/j.immuni.2023.01.004 · Cited by 450 · see citing works

Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis

Harbour, S. N., Maynard, C. L., Zindl, C. L., Schoeb, T. R., & Weaver, C. T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415675112 · Cited by 427 · see citing works

Regulatory T cells under scrutiny

Bach, J. F. (2003) · Nature reviews. Immunology · doi:10.1038/nri1026 · Cited by 414 · see citing works

Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis

Ízcue, A., Hüe, S., Buonocore, S. M., Arancibia-Cárcamo, C. V., Ahern, P. P., Iwakura, Y., Maloy, K. J., & Powrie, F. M. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.019 · Cited by 411 · see citing works

A Crucial Role for the Vitamin D Receptor in Experimental Inflammatory Bowel Diseases

Froicu, M., Weaver, V. C., Wynn, T. A., McDowell, M. A., Welsh, J., & Cantorna, M. T. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0281 · Cited by 407 · see citing works

T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice.

Davidson, N. J., Leach, M. W., Fort, M. M., Thompson-Snipes, L., Kühn, R., Müller, W., Berg, D. J., & Rennick, D. M. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.1.241 · Cited by 402 · see citing works

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo

Darrasse-Jèze, G., Deroubaix, S., Mouquet, H., Victora, G. D., Eisenreich, T., Yao, K.-H., Masilamani, R. F., Dustin, M. L., Rudensky, A. Y., Liu, K., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090746 · Cited by 404 · see citing works

Activation of PPAR γ and δ by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease

Bassaganya-Riera, J., Reynolds, K., Martino‐Catt, S. J., Cui, Y., Hennighausen, L. G., Gonzalez, F. J., Rohrer, J., Uribe-Benninghoff, A., & Hontecillas, R. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.06.049 · Cited by 393 · see citing works

Immunosuppressive and Anti-inflammatory Properties of Interleukin 10

de Vries, J. E. (1995) · Annals of Medicine · doi:10.3109/07853899509002465 · Cited by 391 · see citing works

Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells

Bensinger, S. J., Bandeira, A., Jordan, M. S., Caton, A. J., & Laufer, T. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.4.427 · Cited by 391 · see citing works

Exosomes Released from Tumor-Associated Macrophages Transfer miRNAs That Induce a Treg/Th17 Cell Imbalance in Epithelial Ovarian Cancer

Zhou, J., Li, X., Wu, X., Zhang, T., Zhu, Q., Wang, X., Wang, H., Wang, K., Lin, Y., & Wang, X. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-17-0479 · Cited by 386 · see citing works

Effective treatment of collagen‐induced arthritis by adoptive transfer of CD25+ regulatory T cells

Morgan, M. E., Flierman, R., van Duivenvoorde, L. M., Witteveen, H. J., van Ewijk, W., van Laar, J. M., de Vries, R. R. P., & Toes, R. E. M. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21195 · Cited by 385 · see citing works

Regulatory T Cells Reinforce Intestinal Homeostasis

Barnes, M. J., & Powrie, F. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.011 · Cited by 377 · see citing works

Human CD4+ T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+ T Regulatory Cells

Crellin, N. K., García, R., Hadisfar, O., Allan, S., Steiner, T. S., & Levings, M. K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.12.8051 · Cited by 375 · see citing works

Interactions between diet and the intestinal Microbiota alter intestinal permeability and colitis severity in mice

Llewellyn, S. R., Britton, G. J., Contijoch, E. J., Vennaro, O. H., Mortha, A., Colombel, J.-F., Grinspan, A., Clemente, J. C., Merad, M., & Faith, J. J. (2018) · Gastroenterology · doi:10.1053/j.gastro.2017.11.030 · Cited by 364 · see citing works

TREM-1–expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases

Schenk, M., Bouchon, A., Seibold, F., & Mueller, C. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30602 · Cited by 365 · see citing works

Regulatory T cells – a brief history and perspective

Sakaguchi, S., Wing, K., & Miyara, M. (2007) · European Journal of Immunology · doi:10.1002/eji.200737593 · Cited by 362 · see citing works

Increased intensity lymphodepletion and adoptive immunotherapy—how far can we go?

Muranski, P. J., Boni, A., Wrzesinski, C., Citrin, D. E., Rosenberg, S. A., Childs, R. W., & Restifo, N. P. (2006) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0666 · Cited by 358 · see citing works

Enterococcus faecalis Induces Inflammatory Bowel Disease in Interleukin-10 Knockout Mice

Balish, E., & WARNER, T. F. C. S. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61172-8 · Cited by 352 · see citing works

T cells in inflammatory bowel disease: protective and pathogenic roles

Powrie, F. M. (1995) · Immunity · doi:10.1016/1074-7613(95)90086-1 · Cited by 351 · see citing works

Inflammatory bowel disease

Teitelbaum, D. H., & Coran, A. G. (2006) · CRC Press eBooks · doi:10.1201/b13237-67 · Cited by 341 · see citing works

T cell receptor-alpha beta-deficient mice fail to develop colitis in the absence of a microbial environment.

Dianda, L., Hanby, A., Wright, N. A., Sebesteny, A., Hayday, A., & Owen, M. J. (1997) · Europe PMC (PubMed Central) · Cited by 337 · see citing works

Eos Mediates Foxp3-Dependent Gene Silencing in CD4 + Regulatory T Cells

Pan, F., Yu, H., Dang, E. V., Barbi, J. J., Pan, X., Grosso, J. F., Jinasena, D., Sharma, S. M., McCadden, E., Getnet, D., et al. (2009) · Science · doi:10.1126/science.1176077 · Cited by 335 · see citing works

Bacteria-triggered CD4+ T Regulatory Cells Suppress Helicobacter hepaticus–induced Colitis

Kullberg, M. C., Jankovic, D. L., Gorelick, P. L., Caspar, P., Letterio, J. J., Cheever, A. W., & Sher, A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020556 · Cited by 322 · see citing works

Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus

Cahill, R. J., Foltz, C. J., Fox, J. G., Dangler, C. A., Powrie, F. M., & Schauer, D. B. (1997) · Infection and Immunity · doi:10.1128/iai.65.8.3126-3131.1997 · Cited by 317 · see citing works

The Ubiquitin Ligase Stub1 Negatively Modulates Regulatory T Cell Suppressive Activity by Promoting Degradation of the Transcription Factor Foxp3

Chen, Z., Barbi, J. J., Bu, S., Yang, H., Li, Z., Gao, Y., Jinasena, D., Fu, J. L., Lin, F., Chen, C., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.006 · Cited by 305 · see citing works

IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H)

Jones, J., Phuah, C., Cox, A. L., Thompson, S. A. J., Ban, M., Shawcross, J., Walton, A., Sawcer, S. J., Compston, A., & Coles, A. J. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37878 · Cited by 297 · see citing works

Polyamine metabolism is a central determinant of helper T cell lineage fidelity

Puleston, D. J., Baixauli, F., Sanin, D. E., Edwards-Hicks, J., Villa, M., Kabat, A. M., Kamiński, M. M., Stanckzak, M., Weiss, H. J., Grzes, K. M., et al. (2021) · Cell · doi:10.1016/j.cell.2021.06.007 · Cited by 295 · see citing works

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

Wilson, J. E., Petrucelli, A., Chen, L., Koblansky, A. A., Truax, A. D., Oyama, Y., Rogers, A. B., Brickey, W. J., Wang, Y., Schneider, M., et al. (2015) · Nature Medicine · doi:10.1038/nm.3908 · Cited by 293 · see citing works

Regulatory CD4+ T Cells Expressing Endogenous T Cell Receptor Chains Protect Myelin Basic Protein–specific Transgenic Mice from Spontaneous Autoimmune Encephalomyelitis

Olivares–Villagómez, D., Wang, Y., & Lafaille, J. J. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.10.1883 · Cited by 294 · see citing works

OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset.

Powrie, F. M., & Mason, D. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.6.1701 · Cited by 415 · see citing works

CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells.

Morrissey, P., Charrier, K., Braddy, S., Liggitt, D., & Watson, J. D. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.1.237 · Cited by 476 · see citing works

Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4+, CD45RBhigh T cells to SCID recipients

Aranda, R., Sydora, B. C., McAllister, P. L., Binder, S. W., Yang, H., Targan, S. R., & Kronenberg, M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.7.3464 · Cited by 312 · see citing works

Summary

Powrie, F. M., & Mason, D. (2013)

CD45RBHIGH CD4+ T-CELLS INDUCE A PATHOGENIC TH1 RESPONSE IN THE COLON WHEN TRANSFERRED TO C-B-17 SCID MICE WHICH IS PREVENTED BY CO-TRANSFER OF THE CD45RBLOW POPULATION

Powrie, F. M., Leach, M. W., & Coffman, R. L. (1994) · Journal of Cellular Biochemistry · Cited by 1 · see citing works