Oncogenic Roles of the PI3K/AKT/mTOR axis

Cited by (358)

Items 301–358 of 358

1. Houttuynia cordata triggers type I interferon signaling to promote host defense against Acinetobacter baumannii infection via mTORC1 activation
   Qingqing Xie, Lele Liu, Ziwei Zhang, Yanfeng Li, Xiaopeng Qi, Tao Xu, Xiaoqing Xu · 2025 · Biochemistry and Biophysics Reports
2. PIK3CA mutation profiling in Vietnamese patients with breast cancer
   Linh Dieu Vuong, To Van Ta, Chu Hoàng Hà, Van‐Long Truong, Quang Ngoc Nguyen · 2020 · Meta Gene
3. Metabolic Reprogramming in Kidney Cancer: Implications for Therapy
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4. A-Kinase Interacting Protein 1 Knockdown Restores Chemosensitivity via Inactivating PI3K/AKT and β-Catenin Pathways in Anaplastic Thyroid Carcinoma
   Haiyan Zheng, Qingyuan Lin, Yamin Rao · 2022 · Frontiers in Oncology
5. Hyperinsulinism Gateway Between Diabetes and Cancer: New Roles for Bifunctional Antidiabetic - Anticancer Active Somatostatins, IGF - 1 Inhibitors and Insulin Sensitizers
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6. Network Propagation-based Identification of Oligometastatic Biomarkers in Metastatic Colorectal Cancer
   Qing Jin, Ke‐Xin Yu, Xianze Zhang, Diwei Huo, Denan Zhang, Lei Liu, Hongbo Xie, Binhua Liang, Xiujie Chen · 2023 · Current Bioinformatics
7. K33 only mutant ubiquitin augments bone marrow‐derived dendritic cell‐mediated CTL priming via PI3K‐Akt pathway
   Yi Yun Liang, Xiao Yan Liao, Jun Jun Jia, Yi Zhen Yin, Yue Hua Zhang, FENG GUANG GAO · 2024 · Immunology
8. Identification of potential characteristic genes in chronic skin infections through RNA sequencing and immunohistochemical analysis
   Hongying Cao, Wei Xiong, Mei Zeng, Hu Li, Yan Xu, Zhong Wu, Yingchun Hu · 2024 · Experimental and Therapeutic Medicine
9. dbGVOSCC: a comprehensive database of genetic variation for systems genetics research on oral squamous cell carcinoma
   Yi Zhou, Yutao Wu, Wenjing Shi, Yingbo Zhang, Xingyun Liu, Yuxin Zhang, Chaoying Zhan, Bingyue Chen, Weidong Tian, Bairong Shen · 2025 · Frontiers in Oncology
10. Exploiting Nanostructured Lipid Carriers for Lamivudine Repurposing in Oncology Through Modulation of Key Molecular Pathways
    Yomna A. Moussa, Aya A. Ali, Doaa Elsegaie, O. M. Sarhan, Hameis M. Sleem · 2025 · Journal of Drug Delivery Science and Technology
11. Peptides as integrative modulators for clinical prognosis and targeted therapy in pancreatic cancer
    Bhawana Yadav, Shiva Prasad Kollur, Amena Ali, Payas Arora, Aanika Gupta, P. Saranraj, Vijay Jagdish Upadhye, Pallavi Singh · 2026 · Discover Oncology
12. Detecting the spike protein of COVID-19 deteriorates insulin resistance of skeletal muscle in Chinese diabetes patients: analysis of blood glucose metabolism
    Tianqi Zhang, Hui Peng, Changjv Chen, Hongbing Zheng, Dawei Yang, Ying Liu · 2026 · Archives of Physiology and Biochemistry
13. Modified Liangfu granule exhibits anti-cancer effects in gastric cancer by regulating apoptosis-related proteins and genes
    Ya Li, Lingqun Zhu, Fengqin Shi, Ruibai Li, Xinyi Chen, Zhi Gang Zheng, Bin Qiu, Li Hou · 2019 · Journal of Traditional Chinese Medical Sciences
14. Whole-exome sequencing identified recurrent and novel variants in benzene-induced leukemia
    Dafeng Lin, Dianpeng Wang, Peimao Li, Lihua Deng, Zhimin Zhang, Yanfang Zhang, Ming Zhang, Naixing Zhang · 2023 · BMC Medical Genomics
15. Wilforol A inhibits human glioma cell proliferation and deactivates the PI3K/AKT signaling pathway
    Zhihan Wang, Li Ren, Hao Xu, Zilong Wei, Hong Jun Zeng · 2023 · Acta Biochimica Polonica
16. Cocaine induces vascular smooth muscle cells proliferation via DRP1-mediated mitochondrial fission and PI3K/HIF-1α signaling
    Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura · 2023 · Biochemical and Biophysical Research Communications
17. Research Progress on Inhibitors of PI3K/Akt Signaling Pathway in the Treatment of Gynecological Malignant
    萌倩 王 · 2024 · World Journal of Cancer Research
18. SYT7 promotes breast cancer cells growth through the PI3K/AKT pathway
    Chenghao Luo, Qingfan Mo, Guosheng Ren · 2024 · Translational Cancer Research
19. Development of a machine learning model for predicting the expression of proteins associated with targeted therapy in endometrial cancer
    Chenwen Sun, Qianling Li, Yanan Huang, Yang Xia, M P Li, Xiucong Zhu, Jinke Zhu, Zhenhua Zhao · 2026 · Frontiers in Oncology
20. Sensitivity of MCF-7 cells with differential expression of S6K1 isoforms to the regulatory impact of fibroblasts
    N. Ya. Hotsuliak, Anastasiia Kravchenko, Viktoriia Kosach, I. O. Tykhonkova, А. І. Хоруженко · 2020 · Biopolymers and Cell
21. Identification of an Immune-Related Biomarker Model Based on the CircRNA-Associated Regulatory Network for Esophageal Carcinoma
    Zhaonian Hu, Jun Xie, Xiaochun Chen, Jia Tang, Kaiguo Zhou, Song Han · 2021 · Journal of Oncology
22. Anthocyanins from Lycium ruthenicum Murray inhibit HCC tumor angiogenesis and promote autophagic apoptosis through AMPK/PI3K/AKT/mTOR pathway
    Tingting Wei, Jiajie Cheng, Hongli Fan, Xue Cao, Shu‐Qin Ding, Fei Kang, Fangye Li, Zhisheng Wang · 2023 · Research Square
23. Prognostic model based on autophagy-related lncRNAs in gastric cancer
    Mengqiu Cheng, Wei Cao, Bo Chen · 2020
24. Construction and validation of prognostic model based on autophagy-related lncRNAs in gastric cancer
    Mengqiu Cheng, Wei Cao, Guodong Cao, Xin Xu, Bo Chen · 2021 · Biocell
25. Overexpressed P-S6 Associates with Lymph Node Metastasis and Predicts Poor Prognosis in Non-Small Cell Lung Cancer.
    Yaoxiang Tang, Jiadi Luo, Ying Zhou, Hongjing Zang, Yang Yang, Sile Liu, Hongmei Zheng, Jian Ma, Songqing Fan, Qiuyuan Wen · 2022 · Research Square
26. Identification of seven circRNAs that are repeatedly down-regulated in gastric cancer as a biomarker and their potential miRNA targets
    Qijing Guo, Yushaung Luo, Linglin Zhao, Yan Li, Cuiping Guo, Jie Yang, Xiaofeng Zhou, Dengfeng Ren, Fuxing Zhao, Xiaoqian Chen et al. · 2021 · Research Square
27. Comprehensive analysis reveals a CTHRC1-based fourteen-gene signature for prognosis prediction in colon cancer
    Jianwei Wang, Miaorong Xu, Jiayi Mu, Yiquan Chen, Yali Mu, Xun Ye, Qin Zhou · 2022 · Research Square
28. [Naphthalene allyl trifluoromethyl benzocyclopentanone inhibits proliferation and induces apoptosis of lung cancer A549 cells in vitro].
    Xu Wu, Jiannan He, P Li, Y Wang, Liang Yan, J Ma · 2022 · PubMed Central
29. Joint application of multiple genes in the diagnosis and pathogenesis of metastatic peochormocytoma/paraganglioma based on bioinformatics
    Chunlei Zhang, Yindong Kang, Hongmei Jiao, You Hu, Dehui Chang, Qi Yang · 2022 · Research Square
30. Peer Review #1 of "ClpP regulates breast cancer cell proliferation, invasion and apoptosis by modulating the Src/PI3K/Akt signaling pathway (v0.2)"
    2020 · PeerJ
31. Material Basis and Mechanism of Chansu Injection for COVID-19 Treatment Based on Network Pharmacology and Molecular Docking Technology
    Yong Xu, Wenpan Peng, Di Han, Zhichao Wang, Fanchao Feng, Qi Wu, Xianmei Zhou · 2021 · Research Square
32. Peer Review #2 of "ClpP regulates breast cancer cell proliferation, invasion and apoptosis by modulating the Src/PI3K/Akt signaling pathway (v0.1)"
    2020 · PeerJ
33. Material Basis and Mechanism of Chansu Injection for COVID-19 Treatment Based on Network Pharmacology and Molecular Docking Technology
    Yong Dong Xu, Wenpan Peng, Di Han, Zhichao Wang, Cheng Gu, Fanchao Feng, Xianmei Zhou, Qi Wu · 2021 · Research Square
34. Peer Review #2 of "ClpP regulates breast cancer cell proliferation, invasion and apoptosis by modulating the Src/PI3K/Akt signaling pathway (v0.2)"
    2020 · PeerJ
35. Peer Review #1 of "ClpP regulates breast cancer cell proliferation, invasion and apoptosis by modulating the Src/PI3K/Akt signaling pathway (v0.1)"
    2020 · PeerJ
36. CircHGS enhances the progression of bladder cancer by regulating the miR-513a-5p/VEGFC axis and activating the AKT/mTOR signaling pathway
    Yi Zhu, Hong Xiong, Ling Zuo, Shi-Hao Li, Ruiqi Chen, Hongwei Liu · 2022 · Research Square
37. Hypoxia-inducible factor-1α regulates chemokine receptor type 4 to activate AKT/mTOR pathway to promote the viability and migration of diffuse large B cell lymphoma cells
    Zizhen Xu, Yiyue Liu, Yanyu Su, Geng Lv, Yefei Wang · 2022 · Research Square
38. Community detection in empirical kinase networks identifies new members of signaling pathways
    Celia De Los Angeles Colomina Basanta, Marya Bazzi, Maruan Hijazi, Conrad Bessant, Pedro R. Cutillas · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
39. The Anticancer Effect of Zuojinwan on Gastric Cancer Through Multiple Signaling Pathway via miR-107/RUNX1T1 Axis
    Bin He, Qi Rao, Ruochan Li, Xinyi Peng, Yundan Xu, Gang Zhao · 2022 · Research Square
40. DDIT4 mediated autophagy and ferroptosis through VDR-mTOR signaling pathway in the treatment of diabetic kidney disease
    Haitao Lu, Yuanyuan Jiao, Tianyu Yu, Jing-xuan Shi, Jingwei Tian, Guming Zou, Lin Liu, Wenge Li, Li Zhuo · 2022 · Research Square
41. GLS1 mediates SREBP-1 to promote lipid metabolism in hepatocellular carcinoma through PI3K/AKT/mTORC1 signaling pathway
    Yaocheng Sun, Ying Shen, Yongmin Yan, Jianbo Xi, Wei Luo, Chuanlei Liu, Jianjun Tang · 2023 · Research Square
42. MiR-21-5p delivered by exosomes of placental mesenchymal stem cells targets the PTEN/AKT/mTOR axis to inhibit ovarian granulosa cell apoptosis
    Huidong Liu, Xiao Zhang, Shao-wei Wang · 2023 · Research Square
43. Potential mechanism of Astragalus polysaccharide increasing chemosensitivity of cervical cancer HeLa cells to carboplatin by modulating the PI3K/Akt signaling pathway
    2023 · European Journal of Gynaecological Oncology
44. Role of YWHAG in cell proliferation in gastric cancer
    Yumin Li, Luxi Yang, Yanmei Gu, Ji‐Cheng Li, Xiaomei Li, Songlin Songlin Wu · 2023 · Research Square
45. Additional file 2 of Overexpressed p-S6 associates with lymph node metastasis and predicts poor prognosis in non-small cell lung cancer
    Yaoxiang Tang, Jiadi Luo, Ying Jun Zhou, Hongjing Zang, Yang, Yang, Sile Liu, Hongmei Zheng, Jian Ma, Songqing Fan, Qiuyuan Wen · 2022 · Figshare
46. Effects of Petasitin as Natural Extract on Proliferation and Pathological Changes of Pediatric Neuroblastoma SK-N-SH Cells
    Ling Li, Mingjun Zheng, Weixia Meng · 2024 · Journal of Biomedical Nanotechnology
47. Bioinformatics Analysis Highlights GABRD as a Potential Prognostic Biomarker and Therapeutic Target in Kidney Renal Papillary Cell Carcinoma
    Zhuomiao Zhang, Qingyu Tang, Shixuan Liu, Zhaoqing Du · 2024 · SSRN Electronic Journal
48. Advances in the PI3K/Akt/mTOR Signaling Pathway and Tumor Microenvironment in Glioma Research
    琪琪 张 · 2025 · Advances in Clinical Medicine
49. The Molecular Mechanism of Gpr120 Synergistic Regulation the Development of Mac-T Cells and Milk Lipids Synthesis in Dairy Cows
    Xing-chum HE, Ziwen Zou, Juan Liu, Shuo Han, Lin Luo, Xinli Li, Yangyang Song, Peng Liu, Yang Li, Zhaoyuan Wang et al. · 2025 · SSRN Electronic Journal
50. Additional file 5 of Whole-exome sequencing identified recurrent and novel variants in benzene-induced leukemia
    Lin, Dafeng, Dianpeng Wang, 李培茂, Deng, Lihua, Zhang, Zhimin, Zhang, Yanfang, Zhang, Ming, Zhang, Naixing · 2024 · Figshare
51. Additional file 1 of Overexpressed p-S6 associates with lymph node metastasis and predicts poor prognosis in non-small cell lung cancer
    Yaoxiang Tang, Luo, Jiadi, Zhou, Ying, Hongjing Zang, Yang, Yang, Liu, Sile, Zheng, Hongmei, Ma, Jian, Fan, Songqing, Wen, Qiuyuan · 2022 · Figshare
52. Additional file 1 of Whole-exome sequencing identified recurrent and novel variants in benzene-induced leukemia
    Lin, Dafeng, Dianpeng Wang, 李培茂, Deng, Lihua, Zhang, Zhimin, Zhang, Yanfang, Zhang, Ming, Zhang, Naixing · 2024 · Figshare
53. Additional file 4 of Whole-exome sequencing identified recurrent and novel variants in benzene-induced leukemia
    Lin, Dafeng, Dianpeng Wang, Li, Peimao, Deng, Lihua, Zhang, Zhimin, Zhang, Yanfang, Zhang, Ming, Zhang, Naixing · 2024 · Figshare
54. Additional file 2 of Whole-exome sequencing identified recurrent and novel variants in benzene-induced leukemia
    Lin, Dafeng, Dianpeng Wang, Li, Peimao, Deng, Lihua, Zhang, Zhimin, Zhang, Yanfang, Zhang, Ming, Zhang, Naixing · 2024 · Figshare
55. Additional file 3 of Whole-exome sequencing identified recurrent and novel variants in benzene-induced leukemia
    Lin, Dafeng, Dianpeng Wang, 李培茂, Deng, Lihua, Zhang, Zhimin, Zhang, Yanfang, Zhang, Ming, Zhang, Naixing · 2024 · Figshare
56. A comprehensive review on mushrooms with potent antileukemic activity: current status and prospects
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57. BindingDB Entry 50022406: Recent advances in the development of inhibitors targeting KRAS-G12C and its related pathways.
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