The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Interleukin 6: A Multifunctional Cytokine Regulating Immune Reactions and the Acute Phase Protein Response
Abstract
Cytokines are protein mediators of cell-to-cell communication important in a variety of physiologic and pathophysiologic processes. Only a decade ago information about cytokines was limited to the description of a multitude of ill-defined “factors” present in crude super- natants of cultures of mononuclear cells. Modern techniques of protein chemistry and molecular biology have led to the isolation and precise functional definition of many cytokines, including the interferons, colony-stimulating factors, and a heterogeneous group of agents termed interleukins. The name “interleukins” was originally conceived to designate proteins produced by lymphocytes or monocytes, affecting the growth and/or differentiation of lymphoid, monocytic or myeloid cells. With time it has become apparent that many interleukins are not produced exclusively by white blood cells, nor are their actions restricted to leukocytes. The terms “interleukin” or “lymphokine” are now being used for cytokines that can be produced by a variety of cell types and that can affect the functions of many nonhematopoietic cells. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Cites
Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
Kawano, M., Hirano, T., Matsuda, T., Taga, T., Horii, Y., Iwato, K., Asaoku, H., Tang, B., Tanabe, O., Tanaka, H., et al. (1988) · Nature · doi:10.1038/332083a0 · Cited by 1,633
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., & Kishimoto, T. (1989) · Cell · doi:10.1016/0092-8674(89)90438-8 · Cited by 1,396
Hirano, T., Taga, T., Yasukawa, K., Nakajima, K., Nakano, N., Takatsuki, F., Shimizu, M., Murashima, A., Tsunasawa, S., & Sakiyama, F. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.1.228 · Cited by 351
Cited by
Serum IL‐6 Level and the Development of Disability in Older Persons
Ferrucci, L., Harris, T. B., Guralnik, J. M., Tracy, R. P., Corti, M., Cohen, H. J., Penninx, B., Pahor, M., Wallace, R., & Havlik, R. J. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb01583.x · Cited by 809
Danesh, J., Kaptoge, S., Mann, A. G., Sarwar, N., Wood, A., Angleman, S. B., Wensley, F., Higgins, J. P. T., Lennon, L., Eiriksdottir, G., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050078 · Cited by 676
IL-6 signal transduction and its physiological roles: the signal orchestration model
Kamimura, D., Ishihara, K., & Hirano, T. (2003) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/s10254-003-0012-2 · Cited by 673
Woodroofe, M. N., Sarna, G. S., Wadhwa, M., Hayes, G. M., Loughlin, A. J., Tinker, A., & Cuzner, M. L. (1991) · Journal of Neuroimmunology · doi:10.1016/0165-5728(91)90110-s · Cited by 580
DeLEO, J. A., COLBURN, R. W., NICHOLS, M., & MALHOTRA, A. (1996) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1996.16.695 · Cited by 373
Metadata
- Authors
- Le, J., & Vilček, J.
- Venue
- Pathology Reviews • 1990
- Publisher
- Humana Press
- Published
- 1990
- Volume
- 61
- Issue
- 6
- Pages
- 97-111
- OpenAlex
- W1577568147
- Cited by
- 474
- References
- 3
- FWCI
- 73.92
- Type
- book chapter
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Interleukin 6: A Multifunctional Cytokine Regulating Immune Reactions and the Acute Phase Protein Response. https://app.cochat.ai/papers/10.1007/978-1-4612-0485-5_7
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- Le, J., & Vilček, J. (1990). Interleukin 6: A Multifunctional Cytokine Regulating Immune Reactions and the Acute Phase Protein Response. Pathology Reviews • 1990. https://doi.org/10.1007/978-1-4612-0485-5_7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
