Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
Abstract
Human B cell stimulatory factor 2 (BSF-2) was originally characterized and isolated as a T cell-derived factor that caused the terminal maturation of activated B cells to immunoglobulin-producing cells. Molecular cloning of the complementary DNA predicts that BSF-2 is a protein of relative molecular mass (Mr) 26,000 similar or identical to interferon beta 2, hybridoma plasmacytoma growth factor and hepatocyte stimulating factor. IL-6 has been proposed as a name for this molecule. It is now known that BSF-2 has a wide variety of biological functions and that its target cells are not restricted to normal B cells. Responses are also seen in T cells, plasmacytomas, hepatocytes, haematopoietic stem cells, fibroblasts and rat phoeochromocytoma, PC12 (Satoh, T. et al., manuscript in preparation). Of particular interest to this report is that human BSF-2 is a potent growth factor for murine plasmacytomas and hybridomas. This observation suggested to us that constitutive expression of BSF-2 or its receptor could be responsible for the generation of human myelomas. In this study we report that myeloma cells freshly isolated from patients produce BSF-2 and express its receptors. Moreover, anti-BSF-2 antibody inhibits the in vitro growth of myeloma cells. This is direct evidence that an autocrine loop is operating in oncogenesis of human myelomas.
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IL-6 is a growth factor for plasmacytoma and myeloma.
“Taking the above together with the fact that IL-6 is a growth factor for plasmacytoma and myeloma (28, 37)”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [37]
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- Authors
- Kawano, M., Hirano, T., Matsuda, T., Taga, T., Horii, Y., Iwato, K., Asaoku, H., Tang, B., Tanabe, O., Tanaka, H., Kuramoto, A., & Kishimoto, T.
- Affiliations
- Hiroshima University (JP)
- Venue
- Nature
- Published
- 1988-03
- Volume
- 332
- Issue
- 6159
- Pages
- 83-85
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2007000374
- Cited by
- 1,633
- References
- 1
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 5 · 2023: 13 · 2022: 17 · 2021: 16 · 2020: 19 · 2019: 20 · 2018: 11 · 2017: 20 · 2016: 24 · 2015: 20 · 2014: 23 · 2013: 20 · 2012: 28
- FWCI
- 74.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Keywords
- B cell stimulatory factor 2, interleukin-6, multiple myeloma, autocrine growth factor, myeloma cell growth, IL-6 receptor, carcinogenesis, interferon-beta 2
- MeSH terms
- Antibodies, Cell Division, Growth Substances, Humans, Interleukins, Multiple Myeloma, Receptors, Mitogen, Recombinant Proteins, RNA, Messenger, Tumor Cells, Cultured, Interleukin-6, Receptors, Interleukin-4
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