Cited by 351T-cell and B-cell ImmunologySystemic Lupus Erythematosus ResearchImmunotherapy and Immune Responses

Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production

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Hirano, T, Taga, T, Yasukawa, K, Nakajima, K, Nakano, N, Takatsuki, F, Shimizu, M, Murashima, A +2 more·1987·Proceedings of the National Academy of Sciences

Abstract

The partial amino acid sequence of the NH2 terminus of a factor named human B-cell differentiation factor or B-cell stimulatory factor 2 (BSF-2) has been determined. Antibodies raised against the synthetic peptide corresponding to residues 1-13 of the NH2-terminal sequence specifically react with BSF-2 generated by a T-cell line and by phytohemagglutinin-stimulated normal T cells. Furthermore, the antipeptide antibodies react with a BSF-2-like factor produced by cardiac myxoma as well as uterine cervical carcinoma cells. The results show that BSF-2 functions in vivo as well and suggest that the constitutive production of BSF-2 may be involved in autoantibody production, since patients with cardiac myxoma and uterine carcinoma showed autoantibody production.

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Crossref · 10.1073/pnas.84.1.228

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  • IL-6 is produced by cardiac myxoma cells and Castleman's germinal center cells.

    “Studies in the 1980s also showed that IL-6 is produced by cardiac myxoma cells (42) and Castleman’s germinal center cells (43)”

    From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [42]

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Authors
Hirano, T., Taga, T., Yasukawa, K., Nakajima, K., Nakano, N., Takatsuki, F., Shimizu, M., Murashima, A., Tsunasawa, S., & Sakiyama, F.
Affiliations
The University of Osaka (JP)
Venue
Proceedings of the National Academy of Sciences
Published
1987-01
Volume
84
Issue
1
Pages
228-231
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1986543207
Cited by
351
References
29
Citations by year
2025: 2 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 6 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 1 · 2015: 6 · 2014: 8 · 2013: 2 · 2012: 2
FWCI
15.70
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
B cell differentiation factor, B cell stimulatory factor 2, anti-peptide antibodies, NH2-terminal sequence, autoantibody production, cardiac myxoma, uterine cervical carcinoma, T cell lines, autoantibodies
MeSH terms
Amino Acid Sequence, Antibodies, Autoantibodies, B-Lymphocytes, Cell Line, Chromatography, Affinity, Growth Substances, Humans, Immune Sera, Lymphokines, Interleukin-4

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