Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production
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The partial amino acid sequence of the NH2 terminus of a factor named human B-cell differentiation factor or B-cell stimulatory factor 2 (BSF-2) has been determined. Antibodies raised against the synthetic peptide corresponding to residues 1-13 of the NH2-terminal sequence specifically react with BSF-2 generated by a T-cell line and by phytohemagglutinin-stimulated normal T cells. Furthermore, the antipeptide antibodies react with a BSF-2-like factor produced by cardiac myxoma as well as uterine cervical carcinoma cells. The results show that BSF-2 functions in vivo as well and suggest that the constitutive production of BSF-2 may be involved in autoantibody production, since patients with cardiac myxoma and uterine carcinoma showed autoantibody production.
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IL-6 is produced by cardiac myxoma cells and Castleman's germinal center cells.
“Studies in the 1980s also showed that IL-6 is produced by cardiac myxoma cells (42) and Castleman’s germinal center cells (43)”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [42]
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- Authors
- Hirano, T., Taga, T., Yasukawa, K., Nakajima, K., Nakano, N., Takatsuki, F., Shimizu, M., Murashima, A., Tsunasawa, S., & Sakiyama, F.
- Affiliations
- The University of Osaka (JP)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1987-01
- Volume
- 84
- Issue
- 1
- Pages
- 228-231
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC304176
- OpenAlex
- W1986543207
- Cited by
- 351
- References
- 29
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 6 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 1 · 2015: 6 · 2014: 8 · 2013: 2 · 2012: 2
- FWCI
- 15.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- B cell differentiation factor, B cell stimulatory factor 2, anti-peptide antibodies, NH2-terminal sequence, autoantibody production, cardiac myxoma, uterine cervical carcinoma, T cell lines, autoantibodies
- MeSH terms
- Amino Acid Sequence, Antibodies, Autoantibodies, B-Lymphocytes, Cell Line, Chromatography, Affinity, Growth Substances, Humans, Immune Sera, Lymphokines, Interleukin-4
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