Fuzzy Complexes: A More Stochastic View of Protein Function

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Intrinsic Protein Disorder, Amino Acid Composition, and Histone Terminal Domains

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Thousands of proteins likely to have long disordered regions.

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Structural Basis for the Molecular Recognition between Human Splicing Factors U2AF65 and SF1/mBBP

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Malleable machines take shape in eukaryotic transcriptional regulation

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Structural Basis for Regulation of Protein Phosphatase 1 by Inhibitor-2

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Scrambled Prion Domains Form Prions and Amyloid

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High Affinity Streptococcal Binding to Human Fibronectin Requires Specific Recognition of Sequential F1 Modules

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The Affinity of Ets-1 for DNA is Modulated by Phosphorylation Through Transient Interactions of an Unstructured Region

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The random-coil ‘C’ fragment of the dihydropyridine receptor II-III loop can activate or inhibit native skeletal ryanodine receptors

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A Filovirus-Unique Region of Ebola Virus Nucleoprotein Confers Aberrant Migration and Mediates Its Incorporation into Virions

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AlphaFold and Implications for Intrinsically Disordered Proteins

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Unusual biophysics of intrinsically disordered proteins.

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Intrinsically Disordered Proteins and Their “Mysterious” (Meta)Physics

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A decade and a half of protein intrinsic disorder: Biology still waits for physics

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Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

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Protein intrinsic disorder-based liquid–liquid phase transitions in biological systems: Complex coacervates and membrane-less organelles

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Fuzzy complexes: Specific binding without complete folding

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Intrinsically disordered proteins play diverse roles in cell signaling

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Intrinsically Disordered Proteome of Human Membrane‐Less Organelles

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Dancing Protein Clouds: The Strange Biology and Chaotic Physics of Intrinsically Disordered Proteins

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Promiscuity as a functional trait: intrinsically disordered regions as central players of interactomes

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Alternative splicing of intrinsically disordered regions and rewiring of protein interactions

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RNA Polymerase II C-Terminal Domain: Tethering Transcription to Transcript and Template

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Stochasticity of Biological Soft Matter: Emerging Concepts in Intrinsically Disordered Proteins and Biological Phase Separation

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Intrinsically disordered proteins and biomineralization

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RNA–protein interactions: disorder, moonlighting and junk contribute to eukaryotic complexity

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The molecular mechanism of nuclear transport revealed by atomic-scale measurements

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Myelin management by the 18.5‐kDa and 21.5‐kDa classic myelin basic protein isoforms

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The most important thing is the tail: Multitudinous functionalities of intrinsically disordered protein termini

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Fuzziness in Protein Interactions—A Historical Perspective

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Biomineralization process in hard tissues: The interaction complexity within protein and inorganic counterparts

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The binding mechanisms of intrinsically disordered proteins

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Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin

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The (un)structural biology of biomolecular liquid-liquid phase separation using NMR spectroscopy

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The multifaceted roles of intrinsic disorder in protein complexes

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Behaviour of intrinsically disordered proteins in protein–protein complexes with an emphasis on fuzziness

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Liquid–liquid phase separation as an organizing principle of intracellular space: overview of the evolution of the cell compartmentalization concept

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A New Phase of Networking: The Molecular Composition and Regulatory Dynamics of Mammalian Stress Granules

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FuzDB: database of fuzzy complexes, a tool to develop stochastic structure-function relationships for protein complexes and higher-order assemblies

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Intrinsic Disorder, Protein–Protein Interactions, and Disease

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Sequence-Based Prediction of Fuzzy Protein Interactions

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Recent Developments in the Field of Intrinsically Disordered Proteins: Intrinsic Disorder–Based Emergence in Cellular Biology in Light of the Physiological and Pathological Liquid–Liquid Phase Transitions

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Construction of a Fuzzy and Boolean Logic Gates Based on DNA

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The case for intrinsically disordered proteins playing contributory roles in molecular recognition without a stable 3D structure

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An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex

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The triple power of D³: Protein intrinsic disorder in degenerative diseases

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MyelStones: the executive roles of myelin basic protein in myelin assembly and destabilization in multiple sclerosis

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On the Potential of Machine Learning to Examine the Relationship Between Sequence, Structure, Dynamics and Function of Intrinsically Disordered Proteins

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Single-Molecule FRET of Intrinsically Disordered Proteins

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Interaction of the Eukaryotic Initiation Factor 4E with 4E-BP2 at a Dynamic Bipartite Interface

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Fuzziness enables context dependence of protein interactions

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An intrinsically disordered protein, CP12: jack of all trades and master of the Calvin cycle

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Competing interactions give rise to two-state behavior and switch-like transitions in charge-rich intrinsically disordered proteins

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Antibody Recognition of Disordered Antigens

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Investigation of Intrinsically Disordered Proteins through Exchange with Hyperpolarized Water

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Methods for protein complex prediction and their contributions towards understanding the organisation, function and dynamics of complexes

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Rapid Evolution of Virus Sequences in Intrinsically Disordered Protein Regions

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Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide

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Methods of probing the interactions between small molecules and disordered proteins

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Molecular Basis of Antiangiogenic Thrombospondin-1 Type 1 Repeat Domain Interactions With CD36

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Thermodynamic characterization of the multivalent interactions underlying rapid and selective translocation through the nuclear pore complex

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Conformational Heterogeneity and FRET Data Interpretation for Dimensions of Unfolded Proteins

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Structural Basis for Regulation of RNA-Binding Proteins by Phosphorylation

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Convergent evolution and mimicry of protein linear motifs in host–pathogen interactions

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Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity

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Discovering Putative Prion-Like Proteins in Plasmodium falciparum: A Computational and Experimental Analysis

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The solvent side of proteinaceous membrane-less organelles in light of aqueous two-phase systems

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FuzDB: a new phase in understanding fuzzy interactions

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Quantitative multivalent binding model of the structure, size distribution and composition of the casein micelles of cow milk

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Paradoxes and wonders of intrinsic disorder: Complexity of simplicity

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Intrinsic disorder mediates hepatitis C virus core–host cell protein interactions

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How do disordered regions achieve comparable functions to structured domains?

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DSS1/Sem1, a Multifunctional and Intrinsically Disordered Protein

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Diffusion of a disordered protein on its folded ligand

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The Cellular Prion Protein: A Player in Immunological Quiescence

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Folding and Stability of Ankyrin Repeats Control Biological Protein Function

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Protein structure–function continuum model: Emerging nexuses between specificity, evolution, and structure

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Functional and dysfunctional folding, association and aggregation of caseins

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The intrinsically disordered C-terminal region of Arabidopsis thaliana TCP8 transcription factor acts both as a transactivation and self-assembly domain

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15 N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins

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Globular and disordered—the non-identical twins in protein-protein interactions

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Deciphering the Binding between Nupr1 and MSL1 and Their DNA-Repairing Activity

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Computational approaches for inferring the functions of intrinsically disordered proteins

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Structural metamorphism and polymorphism in proteins on the brink of thermodynamic stability

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Quantifying Protein Disorder through Measures of Excess Conformational Entropy

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Multiple Recognition Motifs in Nucleoporin Nup159 Provide a Stable and Rigid Nup159-Dyn2 Assembly

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Dynamic conformational flexibility and molecular interactions of intrinsically disordered proteins

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Circulating extracellular vesicles and rheumatoid arthritis: a proteomic analysis

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Paradoxes and wonders of intrinsic disorder: Stability of instability

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Disordered epitopes as peptide vaccines

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Fuzzy Complex Formation between the Intrinsically Disordered Prothymosin α and the Kelch Domain of Keap1 Involved in the Oxidative Stress Response

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Computational analysis of candidate prion-like proteins in bacteria and their role

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Heterogeneous Tau-Tubulin Complexes Accelerate Microtubule Polymerization

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Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria

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Comparative nucleic acid chaperone properties of the nucleocapsid protein NCp7 and Tat protein of HIV-1

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Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer’s disease

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Tunable order–disorder continuum in protein–DNA interactions

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Specific Conformational Dynamics and Expansion Underpin a Multi-Step Mechanism for Specific Binding of p27 with Cdk2/Cyclin A

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Intrinsically Disordered Proteins

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The large intracellular loop of hZIP4 is an intrinsically disordered zinc binding domain

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Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate

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Functional unfoldomics: Roles of intrinsic disorder in protein (multi)functionality

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Intrinsic Disorder in Tetratricopeptide Repeat Proteins

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Structure of an Intrinsically Disordered Stress Protein Alone and Bound to a Membrane Surface

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Quantitative Cooperative Binding Model for Intrinsically Disordered Proteins Interacting with Nanomaterials

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Small-Angle X-ray Scattering Signatures of Conformational Heterogeneity and Homogeneity of Disordered Protein Ensembles

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Fairy “tails”: flexibility and function of intrinsically disordered extensions in the photosynthetic world

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Transcriptional enhancers at 40: evolution of a viral DNA element to nuclear architectural structures

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