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Gadd45 in Stress Signaling, Cell Cycle Control, and Apoptosis

Salvador, Jesús M., Brown-Clay, Joshua D., Fornace, Albert J.·2013·Advances in Experimental Medicine and Biology
DOI 10.1007/978-1-4614-8289-5_1
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Abstract

The first identified Gadd45 gene, Gadd45a, encodes a ubiquitously expressed protein that is often induced by DNA damage and other stress signals associated with growth arrest and apoptosis. This protein and the other two members of this small gene family, Gadd45b and Gadd45g, have been implicated in a variety of the responses to cell injury including cell cycle checkpoints, apoptosis, and DNA repair. In vivo, many of the prominent roles for the Gadd45 proteins are associated with signaling mediated by p38 mitogen-activated protein kinases (MAPK). Gadd45 proteins can contribute to p38 activation either by activation of upstream kinase(s) or by direct interaction. In vivo, there are important tissue and cell-type-specific differences in the roles for Gadd45 in MAPK signaling. In addition to being p53-regulated, Gadd45a has been found to contribute to p53 activation via p38. Like other stress and signaling proteins, Gadd45 proteins show complex regulation and numerous effectors.

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Metadata

Authors
Salvador, J. M., Brown-Clay, J. D., & Fornace, A. J.
Venue
Advances in Experimental Medicine and Biology
Publisher
Springer New York
Published
2013
Pages
1-19
ISSN
  • 0065-2598
  • 2214-8019
DOI
10.1007/978-1-4614-8289-5_1
Cited by
308
References
5
Language
en
Licence
www.springer.com/tdm (tdm)

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