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Heparan Sulfate Modulates Slit3-Induced Endothelial Cell Migration
Abstract
Heparan sulfate is a long, linear polysaccharide with sulfation modifications and belongs to the glycosaminoglycan family. Our recent studies elucidated that the axon guidance molecule Slit3 is a new heparan sulfate-binding protein and a novel angiogenic factor by interacting with its cognate receptor Robo4, which is specifically expressed in endothelial cells. Here we describe using heparan sulfate-deficient mouse endothelial cells to determine the co-reception function of heparan sulfate in Slit3-induced endothelial cell migration in a Boyden chamber trans-well migration assay.
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Formation of H vessels is supported by production of SLIT3 in osteoclasts, which also enhances H vessel branching.
“The formation of H vessels is supported by the production of the slit homolog 3 (SLIT3) protein in osteoclasts,131 which also enhances H vessel branching.131–133”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [132]
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Heparan Sulfate ProteoglycansPreprint
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Self-citationRobo4 is a vascular-specific receptor that inhibits endothelial migration
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Cell-surface heparan sulfate is involved in the repulsive guidance activities of Slit2 protein
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Repulsive axon guidance molecule Slit3 is a novel angiogenic factor
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Self-citationGenetic alteration of endothelial heparan sulfate selectively inhibits tumor angiogenesis
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Type H blood vessels in bone modeling and remodeling
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Bone remodeling: an operational process ensuring survival and bone mechanical competence
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A mutant-cell library for systematic analysis of heparan sulfate structure–function relationships
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Self-citationRegulatory mechanisms of Robo4 and their effects on angiogenesis
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Proteomic Profiling Exosomes from Vascular Smooth Muscle Cell
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Self-citationMMP2 Sheds Glypican‐4 to Suppress Slit3‐Robo4 Signaling and Angiogenesis
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Metadata
- Authors
- Qiu, H., Xiao, W., Yue, J., & Wang, L.
- Affiliations
- University of Georgia (US)
- Corresponding author
- Wang, Lianchun
- Venue
- Methods in Molecular Biology
- Publisher
- Springer New York
- Published
- 2014-09-24
- Volume
- 1229
- Pages
- 549-555
- ISSN
- 1064-3745 (ISSN-L)
- 1940-6029
- OpenAlex
- W2402558585
- Cited by
- 12
- References
- 16
- Citations by year
- 2026: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 1
- FWCI
- 0.39
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- Locations
- Methods in molecular biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2p41rr005351-21)
- National Heart, Lung, and Blood Institute (R01HL093339)
- National Institute of General Medical Sciences (GM103390, P41GM103390)
- National Center for Research Resources (RR 005351, P41-RR005351)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- heparan sulfate, SLIT3, endothelial cell migration, Robo4, axon guidance, angiogenesis, glycosaminoglycans
- MeSH terms
- Animals, Cell Movement, Heparan Sulfate, Membrane Proteins, Statistics as Topic, Sus scrofa, Endothelial Cells, Mice
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