Microencapsulation in Clinical Islet Xenotransplantation
Abstract
Allogeneic islet transplantation has become a viable treatment for patients with unstable type 1 diabetes; however, donor shortage and the necessity for immunosuppressive drugs are the major drawbacks of this approach. Microencapsulated porcine islet xenotransplantation could solve these drawbacks. Clinical porcine islet xenotransplantation as well as microencapsulated islet transplantation has been conducted without significant side effects. However, these transplantations are not as efficacious as allogeneic naked islet transplantation. High quality porcine islets, biocompatible capsules, and appropriate implant sites should be the key factors for improving efficacy. With improved efficacy, microencapsulated islet xenotransplantation will solve the major drawbacks associated with current islet transplantation.
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Pancreatic islet xenotransplantation approaches are not yet durable, in part because of eventual increases in circulating proinflammatory cytokines associated with reduced graft viability.
“Of note, similar approaches with pancreatic islet xenotransplantation are not yet durable, in part because of eventual increases in the levels of circulating proinflammatory cytokines associated with reduced graft viability (71, 72).”
From Emerging Therapies in Hypothyroidism (2024) · cites this paper as [72]
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“物材料,因其对植入部位微环境中的细胞和微胶囊内的胰岛都表现出高度的生物相容性[102] [103] [104]。”
- Authors
- Shimoda, M., & Matsumoto, S.
- Affiliations
- National Institute of Global Health and Medicine (JP)
- National Center for Global Health and Medicine (JP)
- Corresponding author
- Matsumoto, Shinichi
- Venue
- Methods in Molecular Biology
- Publisher
- Springer New York
- Published
- 2016-10-14
- Volume
- 1479
- Pages
- 335-345
- ISSN
- 1064-3745 (ISSN-L)
- 1940-6029
- OpenAlex
- W2531402314
- Semantic Scholar
- 64ab15750de017e4e69286cb60b23047bcf7373b
- Cited by
- 18
- References
- 30
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 1
- FWCI
- 18.75
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Methods in molecular biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Surgery › Xenotransplantation and immune response
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- microencapsulation, islet xenotransplantation, porcine islets, type 1 diabetes, allogeneic islet transplantation, implantation site, donor shortage, immunosuppression
- MeSH terms
- Alginates, Animals, Capsules, Cell Separation, Clinical Trials as Topic, Diabetes Mellitus, Type 1, Graft Survival, Hexuronic Acids, Humans, Islets of Langerhans, Swine, Transplantation, Heterologous, Transplantation, Homologous, Islets of Langerhans Transplantation, Cells, Immobilized, Glucuronic Acid
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