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Cited by 33Pancreatic function and diabetesXenotransplantation and immune responseDiabetes and associated disorders

Treatment of diabetes with encapsulated pig islets: an update on current developments

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Zhu, Hai-tao, Lu, Lu, Liu, Xing-yu, Yu, Liang, Lyu, Yi, Wang, Bo·2015·Journal of Zhejiang University-SCIENCE B
DOI 10.1631/jzus.b1400310PMC PMC4432985
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Abstract

The potential use of allogeneic islet transplantation in curing type 1 diabetes mellitus has been adequately demonstrated, but its large-scale application is limited by the short supply of donor islets and the need for sustained and heavy immunosuppressive therapy. Encapsulation of pig islets was therefore suggested with a view to providing a possible alternative source of islet grafts and avoiding chronic immunosuppression and associated adverse or toxic effects. Nevertheless, several vital elements should be taken into account before this therapy becomes a clinical reality, including cell sources, encapsulation approaches, and implantation sites. This paper provides a comprehensive review of xenotransplantation of encapsulated pig islets for the treatment of type 1 diabetes mellitus, including current research findings and suggestions for future studies.

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  • Pancreatic islet xenotransplantation approaches are not yet durable, in part because of eventual increases in circulating proinflammatory cytokines associated with reduced graft viability.

    “Of note, similar approaches with pancreatic islet xenotransplantation are not yet durable, in part because of eventual increases in the levels of circulating proinflammatory cytokines associated with reduced graft viability (71, 72).”

    From Emerging Therapies in Hypothyroidism (2024) · cites this paper as [71]

    The Conclusions (page unavailable) say clinical application of encapsulated pig-islet xenotransplantation is still a long way off. Section 2, “Sources of pig islets” (page unavailable), describes toxic effects of proinflammatory cytokines on adult pig islets, but does not report eventual increases in circulating cytokines or link such increases to reduced graft viability. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Zhu, H.-T., Lu, L., Liu, X.-Y., Yu, L., Lyu, Y., & Wang, B.
Affiliations
First Affiliated Hospital of Xi'an Jiaotong University (CN)
Corresponding author
Wang, Bo
ORCID
Venue
Journal of Zhejiang University-SCIENCE B
Publisher
Zhejiang University Press
Published
2015-05
Volume
16
Issue
5
Pages
329-343
ISSN
  • 1673-1581 (ISSN-L)
  • 1862-1783
DOI
10.1631/jzus.b1400310
PMC
PMC4432985
OpenAlex
W314567553
Cited by
33
References
1
Citations by year
2024: 3 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 3
FWCI
0.77
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Zhejiang University SCIENCE B (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (30700772)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Surgery › Xenotransplantation and immune response
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords
type 1 diabetes, xenotransplantation, islet transplantation, immunosuppression avoidance, cell encapsulation, implantation site
MeSH terms
Animals, Biocompatible Materials, Biomedical Engineering, Clinical Trials as Topic, Diabetes Mellitus, Type 1, Graft Survival, Humans, Immunosuppression Therapy, Immunosuppressive Agents, Swine, Tissue Donors, Transplantation, Heterologous, Islets of Langerhans Transplantation, Mice

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