The DOI matches its Crossref record; 78 of the 79 references it cites were found in a registry or an index.
Morphology of Microglia Across Contexts of Health and Disease
Abstract
Microglia, the brain's resident macrophages, are incredibly plastic and dynamic cells. In this chapter, we aim to describe and classify the many morphological changes they can display in normal development, aging, and disease. Although microglia in healthy adult brain tissue are often ramified with small somas, they can undergo massive and rapid morphological shifts in response to stimuli, becoming amoeboid or hypertrophic. Older animals occasionally contain dystrophic, senescent, and gitter cell-like microglia, and brain injury can be accompanied by an increase in rod cells. By a careful study of microglial morphology, coupled with ultrastructural insights gleaned using electron microscopy, insights can be provided into the functions performed by these various morphological phenotypes.
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In the citing paper
“Microglia activation is observed in various neurodegenerative diseases.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [11]
In the citing paper
“These reactive microglia were found to be clustered near Aβ plaques in various brain regions of AD mice and human postmortems.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [11]
Citations
Cites
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
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A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493
The M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689
ATP mediates rapid microglial response to local brain injury in vivo
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jvenn: an interactive Venn diagram viewer
Bardou, P., Mariette, J., Escudié, F., Djemiel, C., & Klopp, C. (2014) · BMC Bioinformatics · doi:10.1186/1471-2105-15-293 · Cited by 2,506
Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
Lawson, L. J., Perry, V. H., Dri, P., & Gordon, S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90229-w · Cited by 2,045
How neuroinflammation contributes to neurodegeneration
Ransohoff, R. M. (2016) · Science · doi:10.1126/science.aag2590 · Cited by 1,967
New tools for studying microglia in the mouse and human CNS
Bennett, M. L., Bennett, F. C., Liddelow, S. A., Ajami, B., Zamanian, J. L., Fernhoff, N. B., Mulinyawe, S. B., Bohlen, C. J., Adil, A., Tucker, A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525528113 · Cited by 1,804
Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
Zhang, B., Gaiteri, C., Bodea, L.-G., Wang, Z., McElwee, J., Podtelezhnikov, A. A., Zhang, C., Xie, T., Tran, L., Dobrin, R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.030 · Cited by 1,657
Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis
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Cited by
Sorted by citations
Microglia states and nomenclature: A field at its crossroads
Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.020 · Cited by 1,973
Self-citationMicroglia in neurodegenerative diseases: mechanism and potential therapeutic targets
Gao, C., Jiang, J., Tan, Y., & Chen, S. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01588-0 · Cited by 1,616
Neuropathobiology of COVID-19: The Role for Glia
Tremblay, M.-E., Madore, C., Bordeleau, M., Tian, L., & Verkhratsky, A. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.592214 · Cited by 159
Self-citationMicroglial morphometric analysis: so many options, so little consistency
Reddaway, J., Richardson, P., Bevan, R. J., Stoneman, J., & Palombo, M. (2023) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2023.1211188 · Cited by 131
Augusto‐Oliveira, M., Arrifano, G. D. P., Delage, C. I., Tremblay, M., Lopez, M. E. C., & Verkhratsky, A. (2021) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12797 · Cited by 114
Self-citation
Metadata
- Authors
- Savage, J. C., Carrier, M., & Tremblay, M.-È.
- Affiliations
- Centre de recherche du CHU de Québec-Université Laval (CA)
- Université Laval (CA)
- Corresponding author
- Tremblay, Marie-Ève
- Venue
- Methods in Molecular Biology
- Publisher
- Springer New York
- Published
- 2019
- Volume
- 2034
- Pages
- 13-26
- ISSN
- 1064-3745 (ISSN-L)
- 1940-6029
- OpenAlex
- W2965200254
- Cited by
- 232
- References
- 79
- Citations by year
- 2026: 21 · 2025: 49 · 2024: 47 · 2023: 41 · 2022: 33 · 2021: 31 · 2020: 8 · 2019: 2
- FWCI
- 23.36
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Methods in molecular biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- microglia, microglial morphology, ramified microglia, amoeboid microglia, rod photoreceptors, brain injury, brain aging, microglial plasticity, ultrastructure, microglial phenotype
- MeSH terms
- Animals, Brain, Brain Injuries, Humans, Microglia
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