Cited by 232Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

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Morphology of Microglia Across Contexts of Health and Disease

Savage, Julie C., Carrier, Micaël, Tremblay, Marie-Ève·2019·Methods in Molecular Biology

DOI 10.1007/978-1-4939-9658-2_2

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Abstract

Microglia, the brain's resident macrophages, are incredibly plastic and dynamic cells. In this chapter, we aim to describe and classify the many morphological changes they can display in normal development, aging, and disease. Although microglia in healthy adult brain tissue are often ramified with small somas, they can undergo massive and rapid morphological shifts in response to stimuli, becoming amoeboid or hypertrophic. Older animals occasionally contain dystrophic, senescent, and gitter cell-like microglia, and brain injury can be accompanied by an increase in rod cells. By a careful study of microglial morphology, coupled with ultrastructural insights gleaned using electron microscopy, insights can be provided into the functions performed by these various morphological phenotypes.

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Authors: Savage, J. C., Carrier, M., & Tremblay, M.-È.
Affiliations: Centre de recherche du CHU de Québec-Université Laval (CA)
Université Laval (CA)
Corresponding author: Tremblay, Marie-Ève
ORCID: Savage, Julie C.
Carrier, Micaël
Tremblay, Marie-Ève
Venue: Methods in Molecular Biology
Publisher: Springer New York
Published: 2019
Volume: 2034
Pages: 13-26
ISSN: 1064-3745 (ISSN-L)
1940-6029
DOI: 10.1007/978-1-4939-9658-2_2
OpenAlex: W2965200254
Cited by: 232
References: 79
Citations by year: 2026: 21 · 2025: 49 · 2024: 47 · 2023: 41 · 2022: 33 · 2021: 31 · 2020: 8 · 2019: 2
FWCI: 23.36
Type: book chapter
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Methods in molecular biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: microglia, microglial morphology, ramified microglia, amoeboid microglia, rod photoreceptors, brain injury, brain aging, microglial plasticity, ultrastructure, microglial phenotype
MeSH terms: Animals, Brain, Brain Injuries, Humans, Microglia

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Morphology of Microglia Across Contexts of Health and Disease

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