Cited by 39Pancreatic function and diabetesDiabetes Treatment and ManagementDiabetes and associated disorders

Diet-Induced Diabetes in the Sand Rat (Psammomys obesus)

Kaiser, Nurit, Cerasi, Erol, Leibowitz, Gil·2012·Methods in Molecular Biology

Abstract

Insulin deficiency is the underlying cause of hyperglycemia in type 2 diabetes. The gerbil Psammomys obesus (P. obesus) is a naturally insulin resistant rodent with tendency to develop diet-induced hyperglycemia associated with obesity. P. obesus does not exhibit hyperglycemia in its natural desert habitat, feeding on low caloric vegetation. However, when fed regular laboratory chow containing higher caloric density, the animals develop moderate obesity and hyperglycemia. Diabetes development and progression is very fast in P. obesus. The animals reach the irreversible hypoinsulinemic stage of the disease, in which a marked reduction of β-cell mass is apparent, within 4-6 weeks of high caloric diet. The present review describes the P. obesus of the Hebrew University colony, with emphasis on its use for the study of β-cell dysfunction in type 2 diabetes.

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  • The sand rat (Psammomys obesus) is a diurnal, well-accepted and extensively studied model for T2DM.

    “A diurnal, well‐accepted and extensively studied model for T2DM 48, 51, 100, 101, 102, 103 is the sand rat, (Psammomys obesus).”

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Authors
Kaiser, N., Cerasi, E., & Leibowitz, G.
Affiliations
Hebrew University of Jerusalem (IL)
Corresponding author
Kaiser, Nurit
Venue
Methods in Molecular Biology
Publisher
Humana Press
Published
2012
Volume
933
Pages
89-102
ISSN
  • 1064-3745 (ISSN-L)
  • 1940-6029
OpenAlex
W124070935
Cited by
39
References
56
Citations by year
2026: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 1 · 2013: 6
FWCI
25.74
Type
book chapter
Language
en
Open access
closed
Locations
  • Methods in molecular biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords
Psammomys obesus, sand rat, type 2 diabetes, diet-induced diabetes, hyperglycemia, insulin resistance, insulin deficiency, beta-cell dysfunction, beta-cell mass, obesity, hypercaloric diet
MeSH terms
Animals, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Diet, Diabetic, Disease Models, Animal, Gerbillinae, Humans, Insulin, Cytokines, Oxidative Stress, Insulin-Secreting Cells, Rats

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