Cited by 142Pancreatic function and diabetesDiet, Metabolism, and DiseaseDiabetes and associated disorders

Diabetes Mellitus in the Sand Rat Induced by Standard Laboratory Diets

Schmidt-Nielsen, Knut, Haines, Howard B., Hackel, Donald B.·1964·Science

Abstract

During an attempt to establish a laboratory colony of the sand rat ( Psammomys obesus ) we found that this animal invariably became obese and developed severe diabetes mellitus when fed on commercial laboratory rat feed, but remained normal when fed on fresh vegetables only. The signs of diabetes included elevated blood glucose, excessive glucose and ketone bodies in the urine, and cataracts. The diabetic animals showed degeneration of the pancreatic insulin-producing tissue (beta-cells).

Integrity signals

Registry

Crossref · 10.1126/science.143.3607.689

Cites

2 of 2 references verified0 citation errors · 0 not checkable

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Claims the paper makes

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The sand rat (Psammomys obesus) is a diurnal, well-accepted and extensively studied model for T2DM.

    “A diurnal, well‐accepted and extensively studied model for T2DM 48, 51, 100, 101, 102, 103 is the sand rat, (Psammomys obesus).”

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Authors
Schmidt-Nielsen, K., Haines, H. B., & Hackel, D. B.
Affiliations
  • Departments of Zoology and Pathology, Duke University, Durham, North Carolina
  • Duke University (US)
Venue
Science
Published
1964-02-14
Volume
143
Issue
3607
Pages
689-690
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2072246158
Cited by
142
References
2
Citations by year
2025: 2 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 2 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 3
FWCI
20.52
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords
diabetes mellitus, sand rat, Psammomys obesus, obesity, experimental diabetes, cataract, ketonuria, hyperglycemia, diet-induced diabetes
MeSH terms
Animals, Blood Glucose, Diabetes Mellitus, Diet, Gerbillinae, Glucose, Insulin, Obesity, Pancreas, Research, Toxicology, Rats

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