The DOI matches its Crossref record; 257 of the 257 references it cites were found in a registry or an index.
Astroglial Serotonin Receptors as the Central Target of Classic Antidepressants
Open accessAbstract
Major depressive disorder (MDD) presents multiple clinical phenotypes and has complex underlying pathological mechanisms. Existing theories cannot completely explain the pathophysiological mechanism(s) of MDD, while the pharmacology of current antidepressants is far from being fully understood. Astrocytes, the homeostatic and defensive cells of the central nervous system, contribute to shaping behaviors, and regulating mood and emotions. A detailed introduction on the role of astrocytes in depressive disorders is thus required, to which this chapter is dedicated. We also focus on the interactions between classic antidepressants and serotonin receptors, overview the role of astrocytes in the pharmacological mechanisms of various antidepressants, and present astrocytes as targets for the treatment of bipolar disorder. We provide a foundation of knowledge on the role of astrocytes in depressive disorders and astroglial 5-HT 2B receptors as targets for selective serotonin reuptake inhibitors in vivo and in vitro.
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“Thus, our previous reports and others researches all suggested that astrocytic 5-HT 2B receptors may be the potential pharmacological target of SSIRs. 59 , 60 , 366 – 368”
From Major depressive disorder: hypothesis, mechanism, prevention and treatment (2024) · cites this paper as [59]
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Rao, J. S., Ertley, R. N., Lee, H.-J., Rapoport, S. I., & Bazinet, R. P. (2006) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500391 · Cited by 40
RetractedProjections of Global Mortality and Burden of Disease from 2002 to 2030
Mathers, C. D., & Loncar, D. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030442 · Cited by 11,386
Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824
Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Warden, D., Niederehe, G., Thase, M. E., Lavori, P. W., Lebowitz, B. D., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.11.1905 · Cited by 5,643 · cited 1×
“A real-life sequential treatment study demonstrates that nearly 30% of MDD patients fail to achieve remission, even after multiple treatment attempts (Rush et al. 2004, 2006).”
BackgroundSleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411
THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE
Schildkraut, J. J. (1965) · American Journal of Psychiatry · doi:10.1176/ajp.122.5.509 · Cited by 3,568
A review of central 5-HT receptors and their function
Barnes, N. M., & Sharp, T. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00010-6 · Cited by 3,211
The global prevalence of common mental disorders: a systematic review and meta-analysis 1980–2013
Steel, Z., Marnane, C., Iranpour, C., Chey, T., Jackson, J. W., Patel, V., & Silove, D. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu038 · Cited by 2,846
Otte, C., Gold, S. M., Penninx, B. W., Pariante, C. M., Etkin, A., Fava, M., Mohr, D. C., & Schatzberg, A. F. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.65 · Cited by 2,269
Research works printed but not linked: 6
- Liu XJ, Zhou Y, Dong L, Guo Q, Chen WC, Psychiatryet DO (2017) A survey of major depression among elderly population in Wuhan (in Chinese). Chin Ment Health J 11:851–856
- Nemeroff CB, Schatzberg AF, Goldstein DJ, Detke MJ, Mallinckrodt C, Lu Y, Tran PV (2002) Duloxetine for the treatment of major depressive disorder. Psychopharmacol Bull 36:106–132
- Nevitt SJ, Sudell M, Tudur Smith C, Marson AG (2019) Topiramate versus carbamazepine monotherapy for epilepsy: an individual participant data review. Cochrane Database Syst Rev 6:CD012065
- Thiebot MH, Martin P (1991) Effects of benzodiazepines, 5-HT1A agonists and 5-HT3 antagonists in animal models sensitive to antidepressant drugs. In: Rodgers RJ, Cooper SJ (eds) 5-HT1A agonists, 5-HT3 antagonists and benzodiazepines: their comparative behavioural pharmacology. Wiley, Chichester, pp 159–194
- Verkhratsky A, Parpura V (2015) Physiology of astroglia: channels, receptors, transporters, ion signaling and gliotransmission. In: Verkhratsky A, Parpura V (eds) Colloquium series on neuroglia in biology and medicine: from physiology to disease. Morgan & Claypool Publishers, San Rafael, p 172
- Watanabe N, Omori IM, Nakagawa A, Cipriani A, Barbui C, Churchill R, Furukawa TA (2011) Mirtazapine versus other antidepressive agents for depression. Cochrane Database Syst Rev 7:CD006528
Cited by
Sorted by citations
Major depressive disorder: hypothesis, mechanism, prevention and treatment
Cui, L., Li, S., Wang, S., Wu, X., Liu, Y., Yu, W., Wang, Y., Tang, Y., Xia, M., & Li, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01738-y · Cited by 1,244
“59 Administration of fl uoxetine in different concentrations to astrocytes expressing the 5-HT 2B receptor may activate distinct signaling pathways to control gene expression.”
BackgroundSelf-citation
Metadata
- Authors
- Verkhratsky, A., Parpura, V., Scuderi, C., & Li, B.
- Affiliations
- Ikerbasque (ES)
- University of Alabama at Birmingham (US)
- Sapienza University of Rome (IT)
- China Medical University (CN)
- Corresponding author
- Li, Baoman
- Venue
- Advances in Neurobiology
- Publisher
- Springer International Publishing
- Published
- 2021
- Volume
- 26
- Pages
- 317-347
- ISSN
- 2190-5215 (ISSN-L)
- 2190-5223
- PMC
- PMC9015684
- OpenAlex
- W4206134470
- Cited by
- 19
- References
- 257
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 3
- FWCI
- 6.81
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advances in neurobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion, other-oa)
- Funders
- National Institute of General Medical Sciences (R01GM123971)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- astrocytes, serotonin receptors, 5-HT2B receptor, major depressive disorder, selective serotonin reuptake inhibitors, antidepressant mechanism, bipolar disorder, mood regulation
- MeSH terms
- Antidepressive Agents, Astrocytes, Major Depressive Disorder, Humans, Receptors, Serotonin, Selective Serotonin Reuptake Inhibitors
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