Cited by 19Treatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

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Astroglial Serotonin Receptors as the Central Target of Classic Antidepressants

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Verkhratsky, Alexei, Parpura, Vladimir, Scuderi, Caterina, Li, Baoman·2021·Advances in Neurobiology

DOI 10.1007/978-3-030-77375-5_13PMC PMC9015684

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Abstract

Major depressive disorder (MDD) presents multiple clinical phenotypes and has complex underlying pathological mechanisms. Existing theories cannot completely explain the pathophysiological mechanism(s) of MDD, while the pharmacology of current antidepressants is far from being fully understood. Astrocytes, the homeostatic and defensive cells of the central nervous system, contribute to shaping behaviors, and regulating mood and emotions. A detailed introduction on the role of astrocytes in depressive disorders is thus required, to which this chapter is dedicated. We also focus on the interactions between classic antidepressants and serotonin receptors, overview the role of astrocytes in the pharmacological mechanisms of various antidepressants, and present astrocytes as targets for the treatment of bipolar disorder. We provide a foundation of knowledge on the role of astrocytes in depressive disorders and astroglial 5-HT 2B receptors as targets for selective serotonin reuptake inhibitors in vivo and in vitro.

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Sorted by citations

Major depressive disorder: hypothesis, mechanism, prevention and treatment
Cui, L., Li, S., Wang, S., Wu, X., Liu, Y., Yu, W., Wang, Y., Tang, Y., Xia, M., & Li, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01738-y · Cited by 1,244
“59 Administration of ﬂ uoxetine in different concentrations to astrocytes expressing the 5-HT 2B receptor may activate distinct signaling pathways to control gene expression.”
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Authors: Verkhratsky, A., Parpura, V., Scuderi, C., & Li, B.
Affiliations: Ikerbasque (ES)
University of Alabama at Birmingham (US)
Sapienza University of Rome (IT)
China Medical University (CN)
Corresponding author: Li, Baoman
ORCID: Verkhratsky, Alexei
Scuderi, Caterina
Venue: Advances in Neurobiology
Publisher: Springer International Publishing
Published: 2021
Volume: 26
Pages: 317-347
ISSN: 2190-5215 (ISSN-L)
2190-5223
DOI: 10.1007/978-3-030-77375-5_13
PMC: PMC9015684
OpenAlex: W4206134470
Cited by: 19
References: 257
Citations by year: 2026: 5 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 3
FWCI: 6.81
Type: book chapter
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Advances in neurobiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Research Explorer (The University of Manchester) (submittedVersion, other-oa)
Funders: National Institute of General Medical Sciences (R01GM123971)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: astrocytes, serotonin receptors, 5-HT2B receptor, major depressive disorder, selective serotonin reuptake inhibitors, antidepressant mechanism, bipolar disorder, mood regulation
MeSH terms: Antidepressive Agents, Astrocytes, Major Depressive Disorder, Humans, Receptors, Serotonin, Selective Serotonin Reuptake Inhibitors

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Astroglial Serotonin Receptors as the Central Target of Classic Antidepressants

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