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Astroglial Serotonin Receptors as the Central Target of Classic Antidepressants
Open accessAbstract
Major depressive disorder (MDD) presents multiple clinical phenotypes and has complex underlying pathological mechanisms. Existing theories cannot completely explain the pathophysiological mechanism(s) of MDD, while the pharmacology of current antidepressants is far from being fully understood. Astrocytes, the homeostatic and defensive cells of the central nervous system, contribute to shaping behaviors, and regulating mood and emotions. A detailed introduction on the role of astrocytes in depressive disorders is thus required, to which this chapter is dedicated. We also focus on the interactions between classic antidepressants and serotonin receptors, overview the role of astrocytes in the pharmacological mechanisms of various antidepressants, and present astrocytes as targets for the treatment of bipolar disorder. We provide a foundation of knowledge on the role of astrocytes in depressive disorders and astroglial 5-HT 2B receptors as targets for selective serotonin reuptake inhibitors in vivo and in vitro.
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“Thus, our previous reports and others researches all suggested that astrocytic 5-HT 2B receptors may be the potential pharmacological target of SSIRs. 59 , 60 , 366 – 368”
From Major depressive disorder: hypothesis, mechanism, prevention and treatment (2024) · cites this paper as [59]
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Cited by
Sorted by citations
Major depressive disorder: hypothesis, mechanism, prevention and treatment
Cui, L., Li, S., Wang, S., Wu, X., Liu, Y., Yu, W., Wang, Y., Tang, Y., Xia, M., & Li, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01738-y · Cited by 1,244
“59 Administration of fl uoxetine in different concentrations to astrocytes expressing the 5-HT 2B receptor may activate distinct signaling pathways to control gene expression.”
BackgroundSelf-citation
Metadata
- Authors
- Verkhratsky, A., Parpura, V., Scuderi, C., & Li, B.
- Affiliations
- Ikerbasque (ES)
- University of Alabama at Birmingham (US)
- Sapienza University of Rome (IT)
- China Medical University (CN)
- Corresponding author
- Li, Baoman
- Venue
- Advances in Neurobiology
- Publisher
- Springer International Publishing
- Published
- 2021
- Volume
- 26
- Pages
- 317-347
- ISSN
- 2190-5215 (ISSN-L)
- 2190-5223
- PMC
- PMC9015684
- OpenAlex
- W4206134470
- Cited by
- 19
- References
- 257
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 3
- FWCI
- 6.81
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Advances in neurobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion, other-oa)
- Funders
- National Institute of General Medical Sciences (R01GM123971)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- astrocytes, serotonin receptors, 5-HT2B receptor, major depressive disorder, selective serotonin reuptake inhibitors, antidepressant mechanism, bipolar disorder, mood regulation
- MeSH terms
- Antidepressive Agents, Astrocytes, Major Depressive Disorder, Humans, Receptors, Serotonin, Selective Serotonin Reuptake Inhibitors
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