Pathogenesis and Clinical Features of Malaria

Acquired Immunity to Malaria

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The burden of malaria in pregnancy in malaria-endemic areas

Steketee, R., Nahlen, B., Parise, M., & Menendez, C. (2001) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2001.64.28 · Cited by 1,063 · see citing works

Innate immunity to malaria

Stevenson, M. M., & Riley, E. M. (2004) · Nature reviews. Immunology · doi:10.1038/nri1311 · Cited by 652 · see citing works

Severe and complicated malaria

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Severe Malaria

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The Treatment of Malaria

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Enhanced phagocytosis of ring-parasitized mutant erythrocytes: a common mechanism that may explain protection against falciparum malaria in sickle trait and beta-thalassemia trait

Ayi, K., Turrini, F., Piga, A. G., & Arese, P. (2004) · Blood · doi:10.1182/blood-2003-11-3820 · Cited by 359 · see citing works

Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

Liehl, P., Zuzarte-Luís, V., Chan, J., Zillinger, T., Baptista, F., Carapau, D., Konert, M., Hanson, K. K., Carret, C., Lassnig, C., et al. (2014) · Nature Medicine · doi:10.1038/nm.3424 · Cited by 313 · see citing works

α + -Thalassemia protects children against disease caused by other infections as well as malaria

Allen, S. J., O’Donnell, A., Alexander, N. D. E., Alpers, M. P., Peto, T., Clegg, J. B., & Weatherall, D. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14736 · Cited by 303 · see citing works

Association of Transmission Intensity and Age With Clinical Manifestations and Case Fatality of Severe Plasmodium falciparum Malaria

Reyburn, H. (2005) · JAMA · doi:10.1001/jama.293.12.1461 · Cited by 294 · see citing works

Systematic review of amodiaquine treatment in uncomplicated malaria

Olliaro, P., Nevill, C. G., Bras, J. L., Ringwald, P., Mussano, P., Garner, P., & Brasseur, P. (1996) · The Lancet · doi:10.1016/s0140-6736(96)06217-4 · Cited by 281 · see citing works

Respiratory Manifestations of Malaria

Taylor, W. R. J., Hanson, J., Turner, G. D. H., White, N. J., & Dondorp, A. M. (2012) · CHEST Journal · doi:10.1378/chest.11-2655 · Cited by 280 · see citing works

The Relationship between Age and the Manifestations of and Mortality Associated with Severe Malaria

Dondorp, A. M., Lee, S. J., Faiz, M. A., Mishra, S. K., Price, R. N., Tjitra, E., Than, M., Htut, Y., Mohanty, S., Yunus, E. B., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/589287 · Cited by 279 · see citing works

Molecular Aspects of Severe Malaria

Chen, Q., Schlichtherle, M., & Wahlgren, M. (2000) · Clinical Microbiology Reviews · doi:10.1128/cmr.13.3.439 · Cited by 242 · see citing works

Effects of foetal haemoglobin on susceptibility of red cells to Plasmodium falciparum

Pasvol, G., Weatherall, D. J., & Wilson, R. J. (1977) · Nature · doi:10.1038/270171a0 · Cited by 198 · see citing works

Delayed Onset of Malaria — Implications for Chemoprophylaxis in Travelers

Schwartz, E., Parise, M. E., Kozarsky, P. E., & Cetron, M. S. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021592 · Cited by 185 · see citing works

Cytoadherence, pathogenesis and the infected red cell surface in Plasmodium falciparum

Newbold, C., Craig, A. G., Kyes, S., Rowe, J. A., Fernández-Reyes, D., & Fagan, T. (1999) · International Journal for Parasitology · doi:10.1016/s0020-7519(99)00049-1 · Cited by 168 · see citing works

Sequestration and Microvascular Congestion Are Associated With Coma in Human Cerebral Malaria

Ponsford, M., Medana, I. M., Prapansilp, P., Hien, T. T., Lee, S. J., Dondorp, A. M., Esiri, M. M., Day, N. P. J., White, N. J., & Turner, G. D. H. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir812 · Cited by 164 · see citing works

Association of Early Interferon‐γ Production with Immunity to Clinical Malaria: A Longitudinal Study among Papua New Guinean Children

D’Ombrain, M. C., Robinson, L. J., Stanisic, D. I., Taraika, J., Bernard, N. J., Michon, P., Müeller, I., & Schofield, L. (2008) · Clinical Infectious Diseases · doi:10.1086/592971 · Cited by 163 · see citing works

Cytoadherence characteristics of Plasmodium falciparum-infected erythrocytes from Malawian children with severe and uncomplicated malaria.

Rogerson, S. J., Tembenu, R., Dobaño, C., Plitt, S. S., Taylor, T. E., & Molyneux, M. E. (1999) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1999.61.467 · Cited by 162 · see citing works

Burden, Features, and Outcome of Neurological Involvement in Acute Falciparum Malaria in Kenyan Children

Idro, R., Ndiritu, M., Ogutu, B. R., Mithwani, S., Maitland, K., Berkley, J. A., Crawley, J., Fegan, G., Bauni, E., Peshu, N. M., et al. (2007) · JAMA · doi:10.1001/jama.297.20.2232 · Cited by 157 · see citing works

Cerebral malaria

Rénia, L., Howland, S. W., Claser, C., Grüner, A. C., Suwanarusk, R., Teo, T., Russell, B., & Ng, L. F. P. (2012) · Virulence · doi:10.4161/viru.19013 · Cited by 137 · see citing works

Acute Kidney Injury Is Common in Pediatric Severe Malaria and Is Associated With Increased Mortality

Conroy, A. L., Hawkes, M., Elphinstone, R. E., Morgan, C., Hermann, L., Barker, K. R., Namasopo, S., Opoka, R. O., John, C. C., Liles, W. C., et al. (2016) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofw046 · Cited by 118 · see citing works

Differing effects of HbS and HbC traits on uncomplicated falciparum malaria, anemia, and child growth

Kreuels, B., Kreuzberg, C., Kobbe, R., Ayim‐Akonor, M., Appiah–Thompson, P., Thompson, B., Ehmen, C., Adjei, S., Langefeld, I., Adjei, O., et al. (2010) · Blood · doi:10.1182/blood-2009-09-241844 · Cited by 103 · see citing works

Imported Malaria

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The hydration state of human red blood cells and their susceptibility to invasion by Plasmodium falciparum

Tiffert, T., Lew, V. L., Ginsburg, H., Krugliak, M., Croisille, L., & Mohandas, N. (2005) · Blood · doi:10.1182/blood-2004-12-4948 · Cited by 91 · see citing works

Fatal Pediatric Cerebral Malaria Is Associated with Intravascular Monocytes and Platelets That Are Increased with HIV Coinfection

Hochman, S. E., Madaline, T. F., Wassmer, S. C., Mbale, E. W., Choi, N., Seydel, K. B., Whitten, R. O., Varughese, J., Grau, G. E., Kamiza, S., et al. (2015) · mBio · doi:10.1128/mbio.01390-15 · Cited by 88 · see citing works

Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait

Gong, L., Maiteki‐Sebuguzi, C., Rosenthal, P. J., Hubbard, A., DRAKELEY, C. J., Dorsey, G., & Greenhouse, B. (2012) · Blood · doi:10.1182/blood-2011-08-371062 · Cited by 87 · see citing works

THE BURDEN OF THE NEUROCOGNITIVE IMPAIRMENT ASSOCIATED WITH PLASMODIUM FALCIPARUM MALARIA IN SUB-SAHARAN AFRICA

Mung’ala‐Odera, V., Snow, R. W., & Newton, C. R. J. C. (2004) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2004.71.64 · Cited by 86 · see citing works

Cytoadherence of Plasmodium falciparum to intercellular adhesion molecule 1 and chondroitin-4-sulfate expressed by the syncytiotrophoblast in the human placenta

Maubert, B., Guilbert, L. J., & Deloron, P. (1997) · Infection and Immunity · doi:10.1128/iai.65.4.1251-1257.1997 · Cited by 84 · see citing works

Severe Malarial Thrombocytopenia: A Risk Factor for Mortality in Papua, Indonesia

Lampah, D. A., Yeo, T. W., Malloy, M. J., Kenangalem, E., Douglas, N. M., Ronaldo, D., Sugiarto, P., Simpson, J. A., Poespoprodjo, J. R., Anstey, N. M., et al. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu487 · Cited by 84 · see citing works

The triumph of good over evil: protection by the sickle gene against malaria

Bunn, H. F. (2012) · Blood · doi:10.1182/blood-2012-08-449397 · Cited by 83 · see citing works

Pattern of humoral immune response to Plasmodium falciparum blood stages in individuals presenting different clinical expressions of malaria

Leoratti, F. M. S., Durlacher, R. R., Lacerda, M., Alecrim, M. G. C., Ferreira, A. W., Sanchez, M. C. A., & Moraes, S. L. (2008) · Malaria Journal · doi:10.1186/1475-2875-7-186 · Cited by 82 · see citing works

Cytoadherence Characteristics of Plasmodium falciparum Isolates from Thailand: Evidence for Chondroitin Sulfate a as a Cytoadherence Receptor

Chaiyaroj, S. C., Angkasekwinai, P., Buranakiti, A., Looareesuwan, S., Rogerson, S. J., & Brown, G. V. (1996) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1996.55.76 · Cited by 76 · see citing works

Coagulopathy in malaria

Angchaisuksiri, P. (2013) · Thrombosis Research · doi:10.1016/j.thromres.2013.09.030 · Cited by 73 · see citing works

Systemic Inflammatory Response to Malaria During Pregnancy Is Associated With Pregnancy Loss and Preterm Delivery

Fried, M., Kurtis, J. D., Swihart, B., Pond‐Tor, S., Barry, A., Sidibé, Y., Gaoussou, S., Traoré, M., Keita, S., Mahamar, A., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix623 · Cited by 72 · see citing works

The Dynamics of Liver Function Test Abnormalities after Malaria Infection: A Retrospective Observational Study

Woodford, J., Shanks, G. D., Griffin, P. M., Chalon, S., & McCarthy, J. S. (2018) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.17-0754 · Cited by 65 · see citing works

Falciparum malaria and β-thalassaemia trait in northern Liberia

Willcox, M. C., Björkman, A., & Brohult, J. (1983) · Annals of Tropical Medicine and Parasitology · doi:10.1080/00034983.1983.11811722 · Cited by 64 · see citing works

Morphological changes in erythrocytes induced by malarial parasites

Aikawa, M. (1988) · Biology of the Cell · doi:10.1016/0248-4900(88)90077-9 · Cited by 64 · see citing works

Direct Activation of Human Endothelial Cells by Plasmodium falciparum -Infected Erythrocytes

Viebig, N. K., Wulbrand, U., Förster, R., Andrews, K. T., Lanzer, M., & Knolle, P. A. (2005) · Infection and Immunity · doi:10.1128/iai.73.6.3271-3277.2005 · Cited by 60 · see citing works

Cytoadherence of Plasmodium falciparum‐infected erythrocytes in the human placenta

Maubert, B., Fiévet, N., Tami, G., Boudin, C., & Deloron, P. (2000) · Parasite Immunology · doi:10.1046/j.1365-3024.2000.00292.x · Cited by 54 · see citing works

Impairment of the Growth of Plasmodium Falciparum in HbEE Erythrocytes

Nagel, R. L., Raventós-Suárez, C., Fabry, M. E., Tanowitz, H. B., Sicard, D., & Labie, D. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110248 · Cited by 54 · see citing works

Severe Falciparum Malaria Simulating Fulminant Hepatic Failure

Devarbhavi, H. C., Alvares, J. F., & Kumar, K. S. (2005) · Mayo Clinic Proceedings · doi:10.4065/80.3.355 · Cited by 47 · see citing works

Pathophysiological Mechanisms of Severe Anaemia in Malawian Children

van Hensbroek, M. B., Calis, J. C. J., Phiri, K. S., Vet, R. J. W. M., Munthali, F., Kraaijenhagen, R. J., van den Berg, H., Faragher, B. E., Bates, I., & Molyneux, M. E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012589 · Cited by 44 · see citing works

Parasite dynamics in the peripheral blood and the placenta during pregnancy-associated malaria infection

Cohee, L. M., Kalilani‐Phiri, L., Mawindo, P., Joshi, S. N., Adams, M., Kenefic, L. J., Jacob, C. G., Taylor, T. E., & Laufer, M. K. (2016) · Malaria Journal · doi:10.1186/s12936-016-1541-x · Cited by 44 · see citing works

Mutually exclusive var gene expression in the malaria parasite: multiple layers of regulation

Chookajorn, T., Ponsuwanna, P., & Cui, L. (2008) · Trends in Parasitology · doi:10.1016/j.pt.2008.07.005 · Cited by 40 · see citing works

Hemoglobin C Trait Provides Protection From Clinical Falciparum Malaria in Malian Children

Travassos, M. A., Coulibaly, D. M., Laurens, M. B., Dembélé, A., Tolo, Y., Kone, A. K., Traoré, K., Niangaly, A., Guindo, A., Wu, Y., et al. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv308 · Cited by 39 · see citing works

Erythrocyte membrane alterations in Plasmodium falciparum malaria sequestration

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Phagosomal Acidification Prevents Macrophage Inflammatory Cytokine Production to Malaria, and Dendritic Cells Are the Major Source at the Early Stages of Infection

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Increased Phagocytosis of Plasmodium falciparum-Infected Erythrocytes with Haemoglobin E by Peripheral Blood Monocytes

Bunyaratvej, A., Butthep, P., Yuthavong, Y., Fucharoen, S., Khusmith, S., Yoksan, S., & Wasi, P. (2009) · Acta Haematologica · doi:10.1159/000206041 · Cited by 32 · see citing works

Knobs, knob proteins and cytoadherence in falciparum malaria

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Clinical significance of sequestration in adults with severe malaria

Dondorp, A. M. (2008) · Transfusion Clinique et Biologique · doi:10.1016/j.tracli.2008.04.013 · Cited by 28 · see citing works

Plasmodium simium : a Brazilian focus of anthropozoonotic vivax malaria?

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The effect of malarial infection on maternal-fetal outcome in Ecuador

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Uncomplicated Plasmodium vivax malaria in pregnancy associated with mortality from acute respiratory distress syndrome

McGready, R., Wongsaen, K., Chu, C. S., Tun, N. W., Chotivanich, K., White, N. J., & Nosten, F. (2014) · Malaria Journal · doi:10.1186/1475-2875-13-191 · Cited by 27 · see citing works

Acceleration of hemoglobin C crystallization by hemoglobin S

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Familial Aggregation of Cerebral Malaria and Severe Malarial Anemia

Ranque, S., Safeukui, I., Poudiougou, B., Traore, A. M., Keita, M., Traoré, D., Diakité, M., Cissé, M. B., Keita, M. M., Doumbo, O. K., et al. (2005) · The Journal of Infectious Diseases · doi:10.1086/427238 · Cited by 14 · see citing works

Current update on malaria in pregnancy: a systematic review

Minwuyelet, A., Yewhalaw, D., Siferih, M., & Atenafu, G. (2025) · Tropical Diseases, Travel Medicine and Vaccines · doi:10.1186/s40794-025-00248-1 · Cited by 49 · see citing works

Insights into Malaria and HIV Co-infection: Trends and Impact in Sub-Saharan Africa

Ayoola, A. O., Okanlawon, B. M., Idowu, E. M., Adedokun, T. T., Ige, A. A., Olorunfemi, A. B., & Ojurongbe, O. D. (2026) · Current HIV Research · doi:10.2174/011570162x436553260323090833

Heparin-functionalized chitosan-poly(ε-caprolactone) nanoparticles loaded with quinine for selective targeting of infected erythrocytes and enhanced antiplasmodial efficacy

Amos, Y., Ahmed, R., Sauli, E., Rubaka, C., Tambwe, M. M., Tumbo, A., Swai, H., & Dube, A. (2026) · Nanomedicine · doi:10.1080/17435889.2026.2658589

Pathogenesis of Alcohol-Exacerbated Malaria in Plasmodium berghei -Infected MicePreprint

Wanyu, B. Y., Kouémou, N. E., Shinyuy, L. M., Nda, H. T., Jugha, V. T., Ambe, N. F., & Taïwé, G. S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.30.720083

Pathogenesis of Alcohol‐Exacerbated Malaria in Plasmodium berghei ‐Infected Mice

Wanyu, B. Y., Kouémou, N. E., Shinyuy, L. M., Nda, H. T., Jugha, V. T., Ambe, N. F., & Taïwé, G. S. (2026) · Parasite Immunology · doi:10.1111/pim.70105

The war between the malaria parasite and the immune system: immunity, immunoregulation and immunopathology

Artavanis‐Tsakonas, K., Tongren, J. E., & Riley, E. M. (2003) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2003.02174.x · Cited by 369 · see citing works

Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach

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Clinical and parasitological studies on immunity to Plasmodium falciparum malaria in children.

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Editorial Commentary:Mortality Associated with SeverePlasmodium falciparumMalaria Increases with Age

Olliaro, P. (2008) · Clinical Infectious Diseases · doi:10.1086/589288 · Cited by 64 · see citing works

Plasmodium falciparum clinical malaria in Dielmo, a holoendemic area in Senegal: no influence of acquired immunity on initial symptomatology and severity of malaria attacks.

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