Cited by 207Malaria Research and ControlHemoglobinopathies and Related DisordersErythrocyte Function and Pathophysiology

New insights into malaria pathogenesis

Open access
Moxon, Christopher A., Gibbins, Matthew P., McGuinness, Dagmara, Milner, Danny A., Marti, Matthias·2020·Annual Review of Pathology: Mechanisms of Disease

Abstract

Malaria remains a major public health threat in tropical and subtropical regions across the world. Even though less than 1% of malaria infections are fatal, this leads to about 430,000 deaths per year, predominantly in young children in sub-Saharan Africa. Therefore, it is imperative to understand why a subset of infected individuals develop severe syndromes and some of them die and what differentiates these cases from the majority that recovers. Here, we discuss progress made during the past decade in our understanding of malaria pathogenesis, focusing on the major human parasite Plasmodium falciparum.

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Crossref · 10.1146/annurev-pathmechdis-012419-032640

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160 of 160 references verified0 citation errors · 0 not checkable

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Authors
Moxon, C. A., Gibbins, M. P., McGuinness, D., Milner, D. A., & Marti, M.
Affiliations
  • University of Glasgow (GB)
  • Harvard University (US)
Venue
Annual Review of Pathology: Mechanisms of Disease
Published
2020-01-24
Volume
15
Issue
1
Pages
315-343
ISSN
  • 1553-4006 (ISSN-L)
  • 1553-4014
OpenAlex
W2981351520
Cited by
207
References
160
Citations by year
2026: 17 · 2025: 42 · 2024: 40 · 2023: 39 · 2022: 36 · 2021: 25 · 2020: 7 · 2019: 1
FWCI
2.82
Type
journal article
Language
en
Open access
Licence
cc-by-sa
Locations
  • Annual Review of Pathology Mechanisms of Disease (publishedVersion)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
  • Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
Keywords
malaria pathogenesis, Plasmodium falciparum, severe malaria, malaria mortality, host-parasite interactions, Plasmodium falciparum infection
MeSH terms
Child, Child, Preschool, Disease Susceptibility, Humans, Malaria, Plasmodium falciparum, Severity of Illness Index, Malaria, Falciparum, Africa South of the Sahara

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