New insights into malaria pathogenesis
Open accessAbstract
Malaria remains a major public health threat in tropical and subtropical regions across the world. Even though less than 1% of malaria infections are fatal, this leads to about 430,000 deaths per year, predominantly in young children in sub-Saharan Africa. Therefore, it is imperative to understand why a subset of infected individuals develop severe syndromes and some of them die and what differentiates these cases from the majority that recovers. Here, we discuss progress made during the past decade in our understanding of malaria pathogenesis, focusing on the major human parasite Plasmodium falciparum.
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The higher proportion of CM cases by P. falciparum would reflect greater virulence, pathogenicity, and the ability to cross the placenta of this species.
“the higher proportion of CM cases by P. falciparum would reflect greater virulence, pathogenicity, and the ability to cross the placenta of this species [49]”
From Diagnostic Accuracy of a Thick Blood Smear Compared to qPCR for Malaria Associated with Pregnancy in Colombia (2023) · cites this paper as [49]
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Parasite histones mediate leak and coagulopathy in cerebral malariaPreprint
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Self-citation
Flagged first, then by citations
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Prospective study of malaria in pregnancy, placental and congenital malaria in Northwest Colombia
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- Authors
- Moxon, C. A., Gibbins, M. P., McGuinness, D., Milner, D. A., & Marti, M.
- Affiliations
- University of Glasgow (GB)
- Harvard University (US)
- Venue
- Annual Review of Pathology: Mechanisms of Disease
- Publisher
- Annual Reviews
- Published
- 2020-01-24
- Volume
- 15
- Issue
- 1
- Pages
- 315-343
- ISSN
- 1553-4006 (ISSN-L)
- 1553-4014
- OpenAlex
- W2981351520
- Semantic Scholar
- df09695146036e4c2c592ce60b69602be8bd0852
- Cited by
- 207
- References
- 160
- Citations by year
- 2026: 17 · 2025: 42 · 2024: 40 · 2023: 39 · 2022: 36 · 2021: 25 · 2020: 7 · 2019: 1
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- green
- eprints.gla.ac.uk
- Licence
- cc-by-sa
- Locations
- Annual Review of Pathology Mechanisms of Disease (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
- Keywords
- malaria pathogenesis, Plasmodium falciparum, severe malaria, malaria mortality, host-parasite interactions, Plasmodium falciparum infection
- MeSH terms
- Child, Child, Preschool, Disease Susceptibility, Humans, Malaria, Plasmodium falciparum, Severity of Illness Index, Malaria, Falciparum, Africa South of the Sahara
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