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Regulation of Low Density Lipoprotein Uptake and Degradation in Different Animals Species

Dietschy, John M., Spady, David K.·1984·Cologne Atherosclerosis Conference No. 2: Lipids
DOI 10.1007/978-3-0348-7235-5_21
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Abstract

These various observations suggest that the intestinal-hepatic axis plays a key role in the regulation of cholesterol balance in the whole animal and the circulating levels of LDL-cholesterol. Nearly all sterol which enters or leaves the body must do so through the intestine and liver. Changes in the rate of entry or exit of cholesterol (or bile acids) from the animal are met by appropriate reciprocal changes in the rates of cholesterol synthesis in these two organs. As long as these adaptive changes in synthesis are adequate to meet the changing needs for cholesterol in the animal, the rates of receptor-mediated LDL degradation by the liver and intestine remain essentially unchanged as does the plasma LDL-cholesterol concentration. Only when the changes in cholesterol synthesis are inadequate to meet the changing sterol needs (or are blocked by drug administration (22] does the liver increase its rate of receptor-mediated LDL uptake which, in turn, results in significant alterations in circulating plasma LDL-cholesterol levels.

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Research works printed but not linked: 21

  1. . Andersen, J.M. and Dietschy, J.M.: Absolute rtes of cholesterol synthesis in extrahepatic tissues measured with H-labeled water and ’ C-labeled substrates. J. Lipid Res. 20: 740, 1979. · DOI
  2. . Jeske, J.D. and Dietschy, J.M.: Regulation of cholesterol synthesis in vivo in the liver and carcass of the rat measured using [3H]water. J. Lipid Res. 21: 364, 1980. · DOI · Paper page
  3. . Turley, S.D., Andersen, J.M. and Dietschy, J.M.: Rates of sterol synthesis and uptake in the major organs of the rat in vivo. J. Lipid Res. 22: 551, 1981. · DOI
  4. . Spady, G.K. and Dietschy, J.M.: Sterol synthesis in vivo in 18 tissues of the squirrel monkey, guinea pig, rabbit, hamster and rat. J. Lipid Res., 24: 303, 1983. · DOI
  5. . Turley, S.D. and West, C.E.: Effect of cholesterol and cholestyramine feeding and of fasting on sterol synthesis in the liver, ileum, and lung of the guinea pig. Lipids. 11: 511, 1976.
  6. . Andersen, J.M., Turley, S.D. and Dietschy, J.M.: Relative rates of sterol synthesis in the liver and various extrahepatic tissues of normal and cholesterol-fed rabbits. Relationship to plasma lipoprotein and tissue cholesterol levels. Biochim. Biophys. Acta, 711: 421, 1982. · DOI
  7. . Dietschy, J.M. and Wilson, J.D.: Cholesterol synthesis in the squirrel monkey: Relative rates of synthesis in various tissues and mechanisms of control. J. Clin. Invest. 47: 166, 1968. · DOI
  8. . Brown, M.S. and Goldstein, J.L.: Receptor-mediated control of cholesterol metabolism. Science. 191: 150, 1976. · DOI · Paper page
  9. . Brown, M.S. and Goldstein, J.L.: Receptor-mediated endocytosis: Insights from the lipoprotein receptor system. Proc. Natl. Acad. Sci. USA. 76: 3330, 1977. · DOI · Paper page
  10. . Mahley, R.W., Weisgraber, K.H., Melchior, G.W., Innerarity, T.L., and Holcombe, K.S.: Inhibition of receptor-mediated clearance of lysine and arginine-modified lipoproteins from the plasma of rats and monkeys. Proc. Natl. Acad. Sci. USA. 77: 225, 1980. · DOI
  11. . Innerarity, T.L., Pitas, R.E. and Mahley, R.W.: Disparities in the interaction of rat and human lipoproteins with cultured rat fibroblasts and smooth muscle cells. Requirements for homology for receptor binding activity. J. Biol. Chem. 255: 11163, 1980. · DOI
  12. . Koelz, H.R., Sherrill, B.C., Turley, S.D. and Dietschy, J.M.: Correlation of low and high density lipoprotein binding in vivo with rates of lipoprotein degradation in the rat. A comparison of lipoproteins of rat and human origin. J. Biol. Chem., 257: 8061, 1982. · DOI
  13. . Steinbrecher, U.P., Witztum, J.L., Kesaniemi, Y.A. and Elam, R.L.: Comparison of glucosylated low density lipoprotein with methylated or cyclohexanedione-treated low density lipoprotein in the measurement of receptor-independent low density lipoprotein catabolism. J. Clin. Invest. 71: 960, 1983. · DOI
  14. . Dietschy, J.M., Spady, D.K. and Stange, E.F.: Quantitative importance of different organs for cholesterol synthesis and low-density-lipoprotein degradation. Biochem. Soc. Trans., 11: 639–641, 1983.
  15. . Kesaniemi, Y.A., Witztum, J.L. and Steinbrecher, U.P.: Receptor-mediated catabolism of low density lipoprotein in man. J. Clin. Invest. 71: 950, 1982. · DOI
  16. . Pittman, R.C., Attie, A.D., Carew, T.E., and Steinberg, D.: Tissue sites of degradation of low density lipoprotein: Application of a method for determining the fate of plasma proteins. Proc. Natl. Acad. Sci. USA. 76: 5345, 1979. · DOI
  17. . Spady, D.K., Bilheimer, D.W. and Dietschy, J.M.: Rates of receptor-dependent and -independent low density lipoprotein uptake in the hamster. Proc. Natl. Acad. Sci. USA, 80: 3499–3503, 1983. · DOI
  18. Turley, S.D. and Dietschy, J.M.: Cholesterol metabolism and excretion. In The Liver: Biology and Pathobiology, Edited by I. Arias, H. Popper, D. Schachter, and D.A. Shafritz, Raven Press, New York, p. 467. 1982.
  19. . Stange, E.F. and Dietschy, J.M.: Absolute rates of cholesterol synthesis in rat intestine in vitro and in vivo: a comparison of different substrates in slices and isolated cells. J. Lipid Res., 24: 72, 1983. · DOI
  20. . Stange, E.F. and Dietschy, J.M.: Cholesterol synthesis and low density lipoprotein uptake are regulated independently in rat small intestinal epithelium. Proc. Natl. Acad. Sci. USA, 80: 5739–5743, 1983. · DOI
  21. . Bilhemier, D.W., Grundy, S.M., Brown, M.S. and Goldstein, J.L.: Mevinolin and colestipol stimulate receptor-mediated clearance of lower density lipoprotein from plasma in familial hypercholesterolemia heterozygotes. Proc. Natl. Acad. Sci. USA. 80: 4124, 1983. · DOI · Paper page

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Metadata

Authors
Dietschy, J. M., & Spady, D. K.
Venue
Cologne Atherosclerosis Conference No. 2: Lipids
Publisher
Birkhäuser Basel
Published
1984
Pages
177-190
DOI
10.1007/978-3-0348-7235-5_21
Cited by
1
References
0
Language
en

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