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Receptor-Mediated Control of Cholesterol Metabolism: Study of human mutants has disclosed how cells regulate a substance that is both vital and lethal.

Brown, Michael S., Goldstein, Joseph L.·1976·Science
DOI 10.1126/science.174194
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Research works printed but not linked: 53

  1. ASSMANN, G, REGULATION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE-ACTIVITY IN CULTURED SWINE AORTIC SMOOTH-MUSCLE CELLS BY PLASMA LIPOPROTEINS, BIOCHEMISTRY 14: 3996 (1975). · DOI
  2. BAILEY, J.M., CHOLESTEROL UPTAKE FROM DOUBLY LABELED ALPHA-LIPOPROTEINS BY CELLS IN TISSUE-CULTURE, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 159: 580 (1973). · DOI
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  4. BEAUDET, A.L., ACID LIPASE IN CULTURED FIBROBLASTS - CHOLESTEROL ESTER STORAGE DISEASE, JOURNAL OF LABORATORY AND CLINICAL MEDICINE 84: 54 (1974).
  5. Bersot, T. P., Journal of Biological Chemistry 251: 2395 (1976). · DOI · Paper page
  6. BIERMAN, E.L., LIPOPROTEIN UPTAKE BY CULTURED HUMAN ARTERIAL SMOOTH-MUSCLE CELLS, BIOCHIMICA ET BIOPHYSICA ACTA 388: 198 (1975). · DOI
  7. BIERMAN, E.L., LIPOPROTEIN UPTAKE AND METABOLISM BY RAT AORTIC SMOOTH-MUSCLE CELLS IN TISSUE-CULTURE, CIRCULATION RESEARCH 35: 136 (1974). · DOI
  8. BROWN, M.S., REGULATION OF ACTIVITY OF LOW-DENSITY LIPOPROTEIN RECEPTOR IN HUMAN FIBROBLASTS, CELL 6: 307 (1975). · DOI
  9. BROWN, M.S., REGULATION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE-ACTIVITY IN CULTURED HUMAN FIBROBLASTS - COMPARISON OF CELLS FROM A NORMAL SUBJECT AND FROM A PATIENT WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA, JOURNAL OF BIOLOGICAL CHEMISTRY 249: 789 (1974). · DOI
  10. BROWN, M.S., SUPPRESSION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE-ACTIVITY AND INHIBITION OF GROWTH OF HUMAN FIBROBLASTS BY 7-KETOCHOLESTEROL, JOURNAL OF BIOLOGICAL CHEMISTRY 249: 7306 (1974). · DOI · Paper page
  11. BROWN, M.S., CHOLESTEROL ESTER FORMATION IN CULTURED HUMAN FIBROBLASTS - STIMULATION BY OXYGENATED STEROLS, JOURNAL OF BIOLOGICAL CHEMISTRY 250: 4025 (1975). · DOI · Paper page
  12. BROWN, M.S., USE OF MUTANT FIBROBLASTS IN ANALYSIS OF REGULATION OF CHOLESTEROL-METABOLISM IN HUMAN CELLS, JOURNAL OF CELLULAR PHYSIOLOGY 85: 425 (1975). · DOI
  13. BROWN, M.S., ROLE OF LOW-DENSITY LIPOPROTEIN RECEPTOR IN REGULATING CONTENT OF FREE AND ESTERIFIED CHOLESTEROL IN HUMAN FIBROBLASTS, JOURNAL OF CLINICAL INVESTIGATION 55: 783 (1975). · DOI
  14. BROWN, M.S., REGULATION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE-ACTIVITY IN HUMAN FIBROBLASTS BY LIPOPROTEINS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 70: 2162 (1973).
  15. BROWN, M.S., FAMILIAL HYPERCHOLESTEROLEMIA - DEFECTIVE BINDING OF LIPOPROTEINS TO CULTURED FIBROBLASTS ASSOCIATED WITH IMPAIRED REGULATION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE-ACTIVITY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 71: 788 (1974).
  16. BROWN, M.S., RECEPTOR-DEPENDENT HYDROLYSIS OF CHOLESTERYL ESTERS CONTAINED IN PLASMA LOW-DENSITY LIPOPROTEIN, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 72: 2925 (1975).
  17. BROWN, M.S., EXPRESSION OF FAMILIAL HYPERCHOLESTEROLEMIA GENE IN HETEROZYGOTES - MECHANISM FOR A DOMINANT DISORDER IN MAN, SCIENCE 185: 61 (1974). · DOI
  18. BRUCKDORFER, K.R., EXCHANGE OF UNESTERIFIED CHOLESTEROL BETWEEN HUMAN LOW-DENSITY LIPOPROTEINS AND RAT ERYTHROCYTE GHOSTS, BIOCHEMICAL JOURNAL 104: 270 (1967). · DOI
  19. BURKE, J.A., DEFICIENT ACTIVITY OF HEPATIC ACID LIPASE IN CHOLESTEROL ESTER STORAGE-DISEASE, SCIENCE 176: 309 (1972). · DOI
  20. CHEN, H.W., INHIBITION OF CELL-GROWTH BY OXYGENATED DERIVATIVES OF CHOLESTEROL, NATURE 251: 419 (1974). · DOI
  21. DEDUVE, C, LYSOSOMOTROPIC AGENTS, BIOCHEMICAL PHARMACOLOGY 23: 2495 (1974). · DOI · Paper page
  22. DIETSCHY, J.M., CHOLESTEROL SYNTHESIS IN SQUIRREL MONKEY - RELATIVE RATES OF SYNTHESIS IN VARIOUS TISSUES AND MECHANISMS OF CONTROL, JOURNAL OF CLINICAL INVESTIGATION 47: 166 (1968). · DOI
  23. DIETSCHY, J.M., EFFECT OF CHOLESTEROL FEEDING AND FASTING ON STEROL SYNTHESIS IN 17 TISSUES OF RAT, JOURNAL OF LIPID RESEARCH 8: 97 (1967). · DOI · Paper page
  24. DIETSCHY, J.M., REGULATION OF CHOLESTEROL METABOLISM .2., NEW ENGLAND JOURNAL OF MEDICINE 282: 1179 (1970). · DOI
  25. DIETSCHY, J.M., REGULATION OF CHOLESTEROL METABOLISM .3., NEW ENGLAND JOURNAL OF MEDICINE 282: 1241 (1970). · DOI
  26. DIETSCHY, J.M., REGULATION OF CHOLESTEROL METABOLISM .1., NEW ENGLAND JOURNAL OF MEDICINE 282: 1128 (1970). · DOI
  27. FOGELMAN, A.M., CONTROL OF LIPID-METABOLISM IN HUMAN LEUKOCYTES, JOURNAL OF BIOLOGICAL CHEMISTRY 248: 6928 (1973). · DOI
  28. FOGELMAN, A.M., ABNORMAL INDUCTION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME - REDUCTASE IN LEUKOCYTES FROM SUBJECTS WITH HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA, JOURNAL OF BIOLOGICAL CHEMISTRY 250: 2045 (1975). · DOI
  29. FREDRICKSON, D.S., METABOLIC BASIS INHE: 493 (1972).
  30. GOLDSTEIN, J. L., AMERICAN JOURNAL OF MEDICINE 58: 147 (1975). · DOI
  31. GOLDSTEIN, J.L., LIPOPROTEIN RECEPTORS, CHOLESTEROL-METABOLISM, AND ATHEROSCLEROSIS, ARCHIVES OF PATHOLOGY 99: 181 (1975).
  32. Goldstein, J.L., Cell 7: 85 (1976). · DOI
  33. GOLDSTEIN, J.L., BINDING AND DEGRADATION OF LOW-DENSITY LIPOPROTEINS BY CULTURED HUMAN FIBROBLASTS - COMPARISON OF CELLS FROM A NORMAL SUBJECT AND FROM A PATIENT WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA, JOURNAL OF BIOLOGICAL CHEMISTRY 249: 5153 (1974). · DOI · Paper page
  34. GOLDSTEIN, J.L., INHIBITION OF PROTEOLYTIC DEGRADATION OF LOW-DENSITY LIPOPROTEIN IN HUMAN FIBROBLASTS BY CHLOROQUINE, CONCANAVALIN-A, AND TRITON WR 1339, JOURNAL OF BIOLOGICAL CHEMISTRY 250: 7854 (1975). · DOI
  35. GOLDSTEIN, J.L., ROLE OF LYSOSOMAL ACID LIPASE IN METABOLISM OF PLASMA LOW-DENSITY LIPOPROTEIN - OBSERVATIONS IN CULTURED FIBROBLASTS FROM A PATIENT WITH CHOLESTERYL ESTER STORAGE DISEASE, JOURNAL OF BIOLOGICAL CHEMISTRY 250: 8487 (1975). · DOI
  36. GOLDSTEIN, J.L., FAMILIAL HYPERCHOLESTEROLEMIA - IDENTIFICATION OF A DEFECT IN REGULATION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASE-ACTIVITY ASSOCIATED WITH OVERPRODUCTION OF CHOLESTEROL, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 70: 2804 (1973).
  37. GOLDSTEIN, J.L., ESTERIFICATION OF LOW DENSITY LIPOPROTEIN CHOLESTEROL IN HUMAN FIBROBLASTS AND ITS ABSENCE IN HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 71: 4288 (1974).
  38. GOLDSTEIN, J.L., GENETIC-HETEROGENEITY IN FAMILIAL HYPERCHOLESTEROLEMIA - EVIDENCE FOR 2 DIFFERENT MUTATIONS AFFECTING FUNCTIONS OF LOW-DENSITY LIPOPROTEIN RECEPTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 72: 1092 (1975).
  39. GOODMAN, D.S., CHOLESTEROL ESTER METABOLISM, PHYSIOLOGICAL REVIEWS 45: 747 (1965). · DOI
  40. IVERIUS, P.H., INTERACTION BETWEEN HUMAN PLASMA LIPOPROTEINS AND CONNECTIVE-TISSUE GLYCOSAMINOGLYCANS, JOURNAL OF BIOLOGICAL CHEMISTRY 247: 2607 (1972). · DOI
  41. KAYDEN, H.J., CHOLESTEROL REGULATION IN HUMAN LYMPHOCYTE CELL LINES IN CULTURE - ANOTHER EXAMPLE OF GENETIC-CONTROL, CLINICAL RESEARCH 23: A398 (1975).
  42. KHACHADURIAN, A.K., DIAGNOSIS OF FAMILIAL HYPERCHOLESTEROLEMIA BY MEASUREMENT OF STEROL SYNTHESIS IN CULTURED SKIN FIBROBLASTS, ATHEROSCLEROSIS 21: 235 (1975). · DOI
  43. KHACHADURIAN, A. K., JOURNAL OF LABORATORY AND CLINICAL MEDICINE 83: 7 (1974).
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  45. LAKE, B. D., JOURNAL OF PEDIATRICS 76: 262 (1970). · DOI
  46. Rothblat, G. H., Lipid Metabolism in Tissue Culture Cells 6: 129 (1967).
  47. SIPERSTEIN, M.D., CURRENT TOPICS CELLU 2: 65 (1970). · DOI
  48. SKIPSKI, V.P., BLOOD LIPIDS LIPOPRO: 471 (1972).
  49. SLOAN, H.R., ENZYME DEFICIENCY IN CHOLESTERYL ESTER STORAGE-DISEASE, JOURNAL OF CLINICAL INVESTIGATION 51: 1923 (1972). · DOI
  50. SNIDERMAN, A.D., PARADOXICAL INCREASE IN RATE OF CATABOLISM OF LOW-DENSITY LIPOPROTEINS AFTER HEPATECTOMY, SCIENCE 183: 526 (1974). · DOI
  51. STEINMAN, R.M., PINOCYTOSIS IN FIBROBLASTS - QUANTITATIVE STUDIES INVITRO, JOURNAL OF CELL BIOLOGY 63: 949 (1974). · DOI
  52. WERB, Z, CHOLESTEROL METABOLISM IN MACROPHAGE .1. REGULATION OF CHOLESTEROL EXCHANGE, JOURNAL OF EXPERIMENTAL MEDICINE 134: 1545 (1971). · DOI
  53. WIBO, M, PROTEIN DEGRADATION IN CULTURED-CELLS .2. UPTAKE OF CHLOROQUINE BY RAT FIBROBLASTS AND INHIBITION OF CELLULAR PROTEIN DEGRADATION AND CATHEPSIN-B1, JOURNAL OF CELL BIOLOGY 63: 430 (1974). · DOI

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Metadata

Authors
Brown, M. S., & Goldstein, J. L.
Affiliations
University of Texas Allied Health Science Center at Dallas, Dallas 75235
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1976-01-16
Volume
191
Issue
4223
Pages
150-154
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.174194
Cited by
725
References
0
Language
en

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