Functionality of HDL: Antioxidation and Detoxifying Effects

Karlsson, Helen; Kontush, Anatol; James, Richard W.

doi:10.1007/978-3-319-09665-0_5

Cited by 55Paraoxonase enzyme and polymorphismsCholesterol and Lipid MetabolismAntioxidant Activity and Oxidative Stress

Functionality of HDL: Antioxidation and Detoxifying Effects

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Karlsson, Helen, Kontush, Anatol, James, Richard W.·2015·Handbook of Experimental Pharmacology

DOI 10.1007/978-3-319-09665-0_5

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Abstract

High-density lipoproteins (HDL) are complexes of multiple talents, some of which have only recently been recognised but all of which are under active investigation. Clinical interest initially arose from their amply demonstrated role in atherosclerotic disease with their consequent designation as a major cardiovascular disease (CVD) risk factor. However, interest is no longer confined to vascular tissues, with the reports of impacts of the lipoprotein on pancreatic, renal and nervous tissues, amongst other possible targets. The ever-widening scope of HDL talents also encompasses environmental hazards, including infectious agents and environmental toxins. In almost all cases, HDL would appear to have a beneficial impact on health. It raises the intriguing question of whether these various talents emanate from a basic ancestral function to protect the cell.The following chapter will illustrate and review our current understanding of some of the functions attributed to HDL. The first section will look at the antioxidative functions of HDL and possible mechanisms that are involved. The second section will focus specifically on paraoxonase-1 (PON1), which appears to bridge the divide between the two HDL functions discussed herein. This will lead into the final section dealing with HDL as a detoxifying agent protecting against exposure to environmental pathogens and other toxins.

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HDL can protect against atherosclerosis by multiple mechanisms, including the ability to efflux cholesterol from endothelial macrophages (macrophage reverse cholesterol transport), or through anti-inflammatory, antioxidative and antiapoptotic pathways.
“HDL can protect against atherosclerosis by multiple mechanisms, including the ability to efflux cholesterol from endothelial macrophages (macrophage reverse cholesterol transport)43, or through anti-inflammatory44, antioxidative45 and antiapoptotic46 pathways.”
From Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses (2016) · cites this paper as [45]

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Authors: Karlsson, H., Kontush, A., & James, R. W.
Affiliations: Inserm (FR)
University of Geneva (CH)
Corresponding author: James, Richard W.
ORCID: Kontush, Anatol
James, Richard W.
Venue: Handbook of Experimental Pharmacology
Publisher: Springer International Publishing
Published: 2014-12-01
Volume: 224
Pages: 207-228
ISSN: 0171-2004 (ISSN-L)
1865-0325
DOI: 10.1007/978-3-319-09665-0_5
OpenAlex: W36419898
Cited by: 55
References: 119
Citations by year: 2026: 1 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 7 · 2018: 6 · 2017: 6 · 2016: 7 · 2015: 3
FWCI: 5.63
Type: book chapter
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/2.5 (unspecified)
Locations: Handbook of experimental pharmacology (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Funders: National Research Foundation
Institut National de la Santé et de la Recherche Médicale
Université de Genève
Fondation Novartis Consumer Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords: high-density lipoprotein, antioxidant function, detoxification, paraoxonase 1, atherosclerosis, cardiovascular risk, environmental toxins, infectious agents, lipoprotein function, tissue protection
MeSH terms: Animals, Antioxidants, Environmental Exposure, Humans, Lipoproteins, HDL, Oxidative Stress, Aryldialkylphosphatase

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Functionality of HDL: Antioxidation and Detoxifying Effects

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