HDLs in crises
Open accessAbstract
PURPOSE OF REVIEW: The clinical utility of HDLs has been scrutinized upon the publication of Mendelian randomization studies showing no effect of HDL-cholesterol (HDL-C) modifying variants on cardiovascular disease (CVD) outcome. The failures of randomized controlled HDL-C-directed intervention trials have further fueled this skepticism. This general criticism originates from oversimplification that has equated 'HDL-C' with 'HDL' and misconceived both as the 'good cholesterol'. RECENT FINDINGS: HDL particles are heterogeneous and carry hundreds of different lipids, proteins, and microRNAs. Many of them but not cholesterol, that is, HDL-C, contributes to the multiple protective functions of HDLs that probably evolved to manage potentially life-threatening crises. Inflammatory processes modify the composition of HDL particles as well as their individual protein and lipid components, and, as a consequence, also their functionality. Gain of dominant-negative functions makes dysfunctional HDL a part rather than a solution of the endangering situation. Quantification of HDL particle numbers, distinct proteins or lipids, and modifications thereof as well as bioassays of HDL functionality are currently explored toward their diagnostic performance in risk prediction and monitoring of treatment response. SUMMARY: Any successful clinical exploitation of HDLs will depend on the identification of the most relevant (dys)functions and their structural correlates. Stringent or prioritized structure-(dys)function relationships may provide biomarkers for better risk assessment and monitoring of treatment response. The most relevant agonists carried by either functional or dysfunctional HDLs as well as their cellular responders are interesting targets for drug development.
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CETP inhibition probably also extends the lifespan of dysfunctional HDL.
“CETP inhibition probably also extends the lifespan of dysfunctional HDL.”
From HDL cholesterol: reappraisal of its clinical relevance (2017) · cites this paper as [108]
CETP inhibition may eliminate the postulated atheroprotective effect of HDL or even be harmful if HDL gained adverse properties.
“This may not only eliminate the postulated atheroprotective effect but even be harmful if HDL gained adverse properties [9, 74, 108].”
From HDL cholesterol: reappraisal of its clinical relevance (2017) · cites this paper as [108]
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The role of high-density lipoproteins in the regulation of angiogenesis
Tan, J. T. M., Ng, M., & Bursill, C. A. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv104 · Cited by 48 · see citing works
Therapeutic Potential of HDL in Cardioprotection and Tissue Repair
Linthout, S. V., Frias, M. A., Singh, N., & Geest, B. D. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-09665-0_17 · Cited by 48 · see citing works
Brulhart‐Meynet, M., Braunersreuther, V., Brinck, J. W., Montecucco, F., Prost, J., Thomas, A., Galan, K., Pelli, G., Pedretti, S., Vuilleumier, N., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119664 · Cited by 46 · see citing works
Chandra, A., Neeland, I. J., Das, S. R., Khera, A., Turer, A. T., Ayers, C. R., McGuire, D. K., & Rohatgi, A. K. (2015) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2015.01.015 · Cited by 43 · see citing works
Anti-inflammatory Function of High-Density Lipoproteins via Autophagy of IκB Kinase
Gerster, R., Eloranta, J. J., Hausmann, M., Ruiz, P. A., Cosín‐Roger, J., Terhalle, A., Ziegler, U., Kullak-Ublick, G. A., von Eckardstein, A., & Rogler, G. (2014) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2014.12.006 · Cited by 41 · see citing works
Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate
Sutter, I., Park, R., Othman, A., et al. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m050021 · Cited by 39 · see citing works
Yip, J. L. Y., Khawaja, A. P., Chan, M. P. Y., Broadway, D. C., Pető, T., Tufail, A., Luben, R., Hayat, S. A., Bhaniani, A., Wareham, N. J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132565 · Cited by 38 · see citing works
How HDL protects LDL against atherogenic modification
Soran, H., Schofield, J. D., Liu, Y., & Durrington, P. N. (2015) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000194 · Cited by 38 · see citing works
Niyonzima, N., Samstad, E. O., Aune, M. H., Ryan, L., Bakke, S. S., Rokstad, A. M., Wright, S. D., Damås, J. K., Mollnes, T. E., Latz, E., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403044 · Cited by 37 · see citing works
Serum amyloid A impairs the antiinflammatory properties of HDL
Han, C. Y., Tang, C., Guevara, M. E., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86401 · Cited by 36 · see citing works
Niu, W., & Qi, Y. (2015) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.114.000748 · Cited by 35 · see citing works
Steffen, B. T., Guan, W., Remaley, A. T., Paramsothy, P., Heckbert, S. R., McClelland, R. L., Greenland, P., Michos, E. D., & Tsai, M. Y. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304349 · Cited by 35 · see citing works
Large-Scale Candidate Gene Analysis of HDL Particle Features
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Genoux, A., Ruidavets, J., Ferrières, J., Combes, G., Lichtenstein, L., Pons, V., Laffargue, M., Taraszkiewicz, D., Carrié, D., Elbaz, M., et al. (2013) · Journal of Lipid Research · doi:10.1194/jlr.p036335 · Cited by 29 · see citing works
Effects of Established Hypolipidemic Drugs on HDL Concentration, Subclass Distribution, and Function
Gomaraschi, M., Adorni, M. P., Banach, M., Bernini, F., Franceschini, G., & Calabresi, L. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-09665-0_19 · Cited by 27 · see citing works
Excessive centrifugal fields damage high density lipoprotein [S]
Munroe, W. H., Phillips, M. L., & Schumaker, V. N. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m058735 · Cited by 27 · see citing works
Rasmiena, A. A., Barlow, C. K., Ng, T. W., Tull, D., & Meikle, P. J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.11.002 · Cited by 23 · see citing works
Itinerary of high density lipoproteins in endothelial cells
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Self-citationKathiresan, S. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.08.967 · Cited by 21 · see citing works
High-Density Lipoproteins in Stroke
Meilhac, O. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-09665-0_16 · Cited by 19 · see citing works
Moren, X., Lhomme, M., Bulla, A., et al. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201500062 · Cited by 15 · see citing works
Reproducibility and biological variability of HDL's vascular functional assays
O'Neill, F., McLoughlin, E., Riwanto, M., Manz, J., Adler, A., Sutill, E., Khan, T. A., Haywood, R., Kay, C. W. M., D’Aiuto, F., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.06.005 · Cited by 9 · see citing works
Acute high-density lipoprotein therapies
Duong, M., Bartolo, B. A. D., & Nicholls, S. J. (2015) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000235 · Cited by 3 · see citing works
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HDL cholesterol: reappraisal of its clinical relevance
März, W., Kleber, M. E., Scharnagl, H., Speer, T., Zewinger, S., Ritsch, A., Parhofer, K. G., von Eckardstein, A., Landmesser, U., & Laufs, U. (2017) · Clinical Research in Cardiology · doi:10.1007/s00392-017-1106-1 · Cited by 275 · see citing works
Self-citation
- Authors
- von Eckardstein, A., & Rohrer, L.
- Affiliations
- University Hospital Zurich (CH)
- ORCID
- Rohrer, Lucia
- Venue
- Current Opinion in Lipidology
- Published
- 2016-06
- Volume
- 27
- Issue
- 3
- Pages
- 264-273
- ISSN
- 0957-9672 (ISSN-L)
- OpenAlex
- W2319148502
- Cited by
- 33
- References
- 108
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 1 · 2019: 2 · 2018: 6 · 2017: 8 · 2016: 1
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.zora.uzh.ch
- Licence
- other-oa
- Locations
- Current Opinion in Lipidology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- HDL particles, HDL cholesterol, HDL heterogeneity, HDL dysfunction, cardiovascular disease, HDL particle number, microRNA, inflammation, structure-function relationship, biomarkers, cardiovascular risk prediction, treatment response monitoring, drug development
- MeSH terms
- Animals, Cardiovascular Diseases, Humans, Lipoproteins, HDL, Cholesterol, HDL, Signal Transduction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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