Synthesising executable gene regulatory networks from single-cell gene expression data
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Boolean network state-graphs provide insight into key transcription factors involved in state changes and can be used to predict the effect of over-expression or knock-down of a transcription factor.
“The resulting state-graph provides insight into key TFs involved in state changes, and can be used to predict the effect of over-expression or knock-down of a TF.”
From Mapping gene regulatory networks from single-cell omics data (2018) · cites this paper as [28]
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Cites
Metabolic stability and epigenesis in randomly constructed genetic nets
Kauffman, S. A. (1969) · Journal of Theoretical Biology · doi:10.1016/0022-5193(69)90015-0 · Cited by 4,871 · see citing works
Finding the K Shortest Loopless Paths in a Network
Yen, J. Y. (1971) · Management Science · doi:10.1287/mnsc.17.11.712 · Cited by 2,642 · see citing works
On the synthesis of a reactive module
Pnueli, A., & Rosner, R. (1989) · ACM SIGPLAN-SIGACT Symposium on Principles of Programming Languages (POPL) · doi:10.1145/75277.75293 · Cited by 1,452 · see citing works
Stochastic Modelling for Systems Biology
Wilkinson, D. (2006) · Chapman & Hall/CRC eBooks · doi:10.1201/9781420010664 · Cited by 1,041 · see citing works
Moignard, V., Woodhouse, S., Haghverdi, L., Lilly, A. J., Tanaka, Y., Wilkinson, A. C., Buettner, F., Macaulay, I. C., Jawaid, W., Diamanti, E., et al. (2015) · Nature Biotechnology · doi:10.1038/nbt.3154 · Cited by 380 · see citing works
Self-citationDefining an essential transcription factor program for naïve pluripotency
Dunn, S.-J., Martello, G., Yordanov, B., Emmott, S., & Smith, A. G. (2014) · Science · doi:10.1126/science.1248882 · Cited by 370 · see citing works
Stochastic Modelling for Systems Biology
Wilkinson, D. J. (2011) · CRC Press eBooks · doi:10.1201/b11812 · Cited by 310 · see citing works
Synchronous versus asynchronous modeling of gene regulatory networks
Garg, A., Cara, A. D., Xénarios, I., Mendoza, L., & Micheli, G. D. (2008) · Bioinformatics · doi:10.1093/bioinformatics/btn336 · Cited by 305 · see citing works
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Guo, G., Luc, S., Marco, E., Lin, T.-W., Peng, C., Kerényi, M., Beyaz, S., Kim, W., Xu, J., Das, P., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.07.017 · Cited by 245 · see citing works
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Solar-Lezama, A., Rabbah, R., Bodík, R., & Ebci̇oğlu, K. (2005) · ACM SIGPLAN Notices · doi:10.1145/1064978.1065045 · Cited by 202 · see citing works
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Solar-Lezama, A., Rabbah, R., Bodík, R., & Ebcioğlu, K. (2005) · Proceedings of the 2005 ACM SIGPLAN conference on Programming language design and implementation · doi:10.1145/1065010.1065045 · Cited by 167 · see citing works
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Pina, C., Fugazza, C., Tipping, A. J., Brown, J., Soneji, S., Teles, J., Peterson, C., & Enver, T. (2012) · Nature Cell Biology · doi:10.1038/ncb2442 · Cited by 162 · cited 1× · see citing works
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Xu, H., Ang, Y.-S., Sevilla, A., Lemischka, I. R., & Ma’ayan, A. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003777 · Cited by 96 · see citing works
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Srivastava, S., Gulwani, S., & Foster, J. S. (2012) · International Journal on Software Tools for Technology Transfer · doi:10.1007/s10009-012-0223-4 · Cited by 89 · see citing works
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Zheng, D., Yang, G., Li, X., Wang, Z., Liu, F., & He, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060593 · Cited by 57 · see citing works
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Cook, B., Fisher, J., Hall, B. A., Ishtiaq, S. S., Juniwal, G., & Piterman, N. (2014) · Lecture notes in computer science · doi:10.1007/978-3-319-08867-9_24 · Cited by 9 · see citing works
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- Authors
- Fisher, J., Köksal, A. S., Piterman, N., & Woodhouse, S.
- Affiliations
- University of Cambridge (GB)
- University of California System (US)
- University of Leicester (GB)
- Corresponding author
- Woodhouse, Steven
- Venue
- Lecture Notes in Computer Science
- Publisher
- Springer International Publishing
- Published
- 2015
- Pages
- 544-560
- ISSN
- 0302-9743 (ISSN-L)
- 1611-3349
- OpenAlex
- W1502207813
- Cited by
- 18
- References
- 28
- Citations by year
- 2023: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 1
- FWCI
- 15.84
- Type
- conference paper
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Lecture notes in computer science (publishedVersion)
- arXiv (Cornell University) (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- arXiv (Cornell University)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Keywords
- gene regulatory networks, Boolean networks, single-cell gene expression, network inference, phase space reconstruction, asynchronous Boolean networks, model synthesis, embryonic development, blood development
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