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Prevention of Type 2 Diabetes
Abstract
Abstract This chapter discusses the prevention of type 2 diabetes. People at high risk of developing type 2 diabetes can often be identified with simple clinical tests. Many of the risk factors—such as obesity, physical inactivity, and subdiagnostic elevations in glycemia—that predict which of these people are most likely to develop diabetes are potentially modifiable. Randomized clinical trials have confirmed that treatment of diabetes risk factors in high-risk persons can reduce the development of new cases of diabetes. However, none of the tested interventions are fully successful at preventing diabetes, indicating that more effective interventions are needed.
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“Although interventions can clearly reduce diabetes incidence over a period of a few years,1–5 it is not well known how long their effects persist, especially when interventions cease or become less intensive.”
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Cited by
Sorted by citations
Knowler, W. C., Doherty, L., Edelstein, S. L., Bennett, P. H., Dabelea, D., Hoskin, M., Kahn, S. E., Kalyani, R. R., Kim, C., Pi-Sunyer, F. X., et al. (2025) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(25)00022-1 · Cited by 39
Self-citation
Metadata
- Authors
- Knowler, W. C.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Knowler, William C.
- Venue
- Endocrinology
- Publisher
- Springer International Publishing
- Published
- 2018
- Volume
- 171
- Issue
- 15
- Pages
- 1-20
- ISSN
- 0003-9926 (ISSN-L)
- 2510-1927
- 2510-1935
- OpenAlex
- W1511319154
- Cited by
- 194
- References
- 0
- Citations by year
- 2021: 10 · 2020: 8 · 2019: 10 · 2018: 17
- FWCI
- 9.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- Endocrinology (publishedVersion)
- Oxford University Press eBooks (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (ZIADK075078)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- type 2 diabetes prevention, diabetes risk factors, obesity, physical inactivity, prediabetes, high-risk individuals, diabetes screening, lifestyle intervention, randomized controlled trials
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