Cited by 28Mesenchymal stem cell researchPeriodontal Regeneration and TreatmentsBone Tissue Engineering Materials

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The role of bone marrow derived mesenchymal stem cells in sports injuries

Vris, Alex, Aresti, Nick, Khan, Wasim S., Malik, Atif A.·2016·Stem Cells in Clinical Applications

DOI 10.1007/978-3-319-40144-7_14

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Abstract

The therapeutic use of bone marrow-derived mesenchymal stem cells (BM-MSCs) has been applied to many different tissue types that are vulnerable to sports injuries. Avenues of treatment include direct injection of BM-MSCs into the defect, however although minimally invasive, research has highlighted flaws which have been improved upon with the use of scaffolds. BM-MSCs have been applied via many different scaffold types, for example PLGA, collagen gel and coral each with advantages and disadvantages of which can be improved through further research. As a cell source for tissue engineering, BM-MSCs are ideal due to the minimal invasion of aspiration, high in vitro proliferation rate and the ability to maintain their differentiating capacity. The vast majority of these studies are at the small animal stage and therefore further work using larger animal models, and ideally humans is required.

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Authors: Vris, A., Aresti, N., Khan, W. S., & Malik, A. A.
Affiliations: Barts Health NHS Trust (GB)
University of Cambridge (GB)
Stoke Mandeville Hospital (GB)
Corresponding author: Malik, Atif A.
ORCID: Aresti, Nick
Khan, Wasim S.
Venue: Stem Cells in Clinical Applications
Publisher: Springer International Publishing
Published: 2016
Volume: 5
Issue: 4
Pages: 277-291
ISSN: 2365-4198 (ISSN-L)
2365-4201
DOI: 10.1007/978-3-319-40144-7_14
OpenAlex: W136516790
Cited by: 28
References: 63
Citations by year: 2023: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2018: 1 · 2017: 4 · 2016: 6
FWCI: 8.75
Type: book chapter
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Stem cells in clinical applications (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords: bone marrow-derived mesenchymal stem cells, sports injuries, cell therapy, scaffolds, PLGA, collagen gel, coral scaffold, tissue engineering, cell injection, tissue regeneration
MeSH terms: Animals, Athletic Injuries, Bone and Bones, Bone Marrow Cells, Cartilage, Humans, Ligaments, Muscles, Tendons, Tissue Engineering, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells

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The role of bone marrow derived mesenchymal stem cells in sports injuries

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