The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
Molecular Targets of the Phytocannabinoids: A Complex Picture
Open accessAbstract
For centuries, hashish and marihuana, both derived from the Indian hemp Cannabis sativa L., have been used for their medicinal, as well as, their psychotropic effects. These effects are associated with the phytocannabinoids which are oxygen containing C21 aromatic hydrocarbons found in Cannabis sativa L. To date, over 120 phytocannabinoids have been isolated from Cannabis. For many years, it was assumed that the beneficial effects of the phytocannabinoids were mediated by the cannabinoid receptors, CB1 and CB2. However, today we know that the picture is much more complex, with the same phytocannabinoid acting at multiple targets. This contribution focuses on the molecular pharmacology of the phytocannabinoids, including Δ9-THC and CBD, from the prospective of the targets at which these important compounds act.
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Cites
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Cited by
Cannabinoid Ligands Targeting TRP Channels
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Self-citationA new ESI-LC/MS approach for comprehensive metabolic profiling of phytocannabinoids in Cannabis
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Medicinal properties of terpenes found in Cannabis sativa and Humulus lupulus
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Maccarrone, M., Di Marzo, V., Gertsch, J., Grether, U., Howlett, A. C., Hua, T., Makriyannis, A., Piomelli, D., Ueda, N., & van der Stelt, M. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000600 · Cited by 183
How effective and safe is medical cannabis as a treatment of mental disorders? A systematic review
Hoch, E., Niemann, D., von Keller, R., Schneider, M., Friemel, C. M., Preuss, U. W., Hasan, A., & Pogarell, O. (2019) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-019-00984-4 · Cited by 131
Metadata
- Authors
- Morales, P., Hurst, D. P., & Reggio, P. H.
- Venue
- Progress in the Chemistry of Organic Natural Products
- Publisher
- Springer International Publishing
- Published
- 2017
- Volume
- 103
- Pages
- 103-131
- ISSN
- 0071-7886 (ISSN-L)
- 2191-7043
- 2192-4309
- OpenAlex
- W2582140652
- Cited by
- 454
- References
- 126
- FWCI
- 71.48
- Type
- book chapter
- Language
- en
- Open access
- green
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