The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Mechanisms of Cytomegalovirus-Accelerated Vascular Disease: Induction of Paracrine Factors That Promote Angiogenesis and Wound Healing
Open accessAbstract
Human cytomegalovirus (HCMV) is associated with the acceleration of a number of vascular diseases such as atherosclerosis, restenosis, and transplant vascular sclerosis (TVS). All of these diseases are the result of either mechanical or immune-mediated injury followed by inflammation and subsequent smooth muscle cell (SMC) migration from the vessel media to the intima and proliferation that culminates in vessel narrowing. A number of epidemiological and animal studies have demonstrated that CMV significantly accelerates TVS and chronic rejection (CR) in solid organ allografts. In addition, treatment of human recipients and animals alike with the antiviral drug ganciclovir results in prolonged survival of the allograft, indicating that CMV replication is a requirement for acceleration of disease. However, although virus persists in the allograft throughout the course of disease, the number of directly infected cells does not account for the global effects that the virus has on the acceleration of TVS and CR. Recent investigations of up- and downregulated cellular genes in infected allografts in comparison to native heart has demonstrated that rat CMV (RCMV) upregulates genes involved in wound healing (WH) and angiogenesis (AG). Consistent with this result, we have found that supernatants from HCMV-infected cells (HCMV secretome) induce WH and AG using in vitro models. Taken together, these findings suggest that one mechanism for HCMV acceleration of TVS is mediated through induction of secreted cytokines and growth factors from virus-infected cells that promote WH and AG in the allograft, resulting in the acceleration of TVS. We review here the ability of CMV infection to alter the local environment by producing cellular factors that act in a paracrine fashion to enhance WH and AG processes associated with the development of vascular disease, which accelerates chronic allograft rejection.
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“Considering recent evidence implicating angiogenesis in HCMV-associated vasculopathies (128), Dumortier et al. (124) profiled the secretome of HCMV-infected human dermal fibroblasts.”
From The Impact of Mass Spectrometry–Based Proteomics on Fundamental Discoveries in Virology (2014) · cites this paper as [128]
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Cites
J Heart Lung Transplant 2021;40(4).
(2021) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2021.04.002 · Cited by 6,824
Angiogenesis in health and disease
Carmeliet, P. (2003) · Nature Medicine · doi:10.1038/nm0603-653 · Cited by 4,379
Regulation of Wound Healing by Growth Factors and Cytokines
WERNER, S., & GROSE, R. (2003) · Physiological Reviews · doi:10.1152/physrev.2003.83.3.835 · Cited by 3,629
Cytomegalovirus Infection Is Associated With Cardiac Allograft Rejection and Atherosclerosis
Grattan, M. T. (1989) · JAMA · doi:10.1001/jama.1989.03420240075030 · Cited by 966
Wegener, J., Keese, C. R., & Giæver, I. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4919 · Cited by 773
Potential Role of Human Cytomegalovirus and p53 Interaction in Coronary Restenosis
Speir, E. H., Modali, R., Huang, E., Leon, M. B., Shawl, F. A., Finkel, T., & Epstein, S. E. (1994) · Science · doi:10.1126/science.8023160 · Cited by 753
Angiogenesis Assays: A Critical Overview
Auerbach, R., Lewis, R. L., Shinners, B., Kubai, L., & Akhtar, N. (2003) · Clinical Chemistry · doi:10.1373/49.1.32 · Cited by 705
Fundamental Concepts of the Angiogenic Process
Folkman, J. (2003) · Current Molecular Medicine · doi:10.2174/1566524033479465 · Cited by 666
The Human Cytomegalovirus Chemokine Receptor US28 Mediates Vascular Smooth Muscle Cell Migration
Streblow, D. N., Söderberg‐Nauclér, C., Vieira, J., Smith, P., Wakabayashi, E., Ruchti, F., Mattison, K., Altschuler, Y., & Nelson, J. A. (1999) · Cell · doi:10.1016/s0092-8674(00)81539-1 · Cited by 439
Self-citationElectrical wound-healing assay for cells in vitro
Keese, C. R., Wegener, J., Walker, S. R., & Giæver, I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307588100 · Cited by 423
Research works printed but not linked: 1
- Melnick JL, Adam E, DeBakey ME (1998) The link between CMV and atherosclerosis. Infect Med 15:479–486.
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Forte, E., Zhang, Z., Thorp, E. B., & Hummel, M. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00130 · Cited by 284
Cytomegalovirus infection is associated with increased mortality in the older population
Savva, G. M., Pachnio, A., Kaul, B., Morgan, K., Huppert, F. A., Brayne, C., & Moss, P. A. H. (2013) · Aging Cell · doi:10.1111/acel.12059 · Cited by 216
Yu, Y., Clippinger, A. J., & Alwine, J. C. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.04.002 · Cited by 199
The Immune Response to Human CMV
Rosa, C. L., & Diamond, D. J. (2012) · Future Virology · doi:10.2217/fvl.12.8 · Cited by 190
van de Berg, P. J., Heutinck, K. M., Raabe, R., Minnee, R. C., Young, S. L., der Pant, K. A. M. I. V. D., Bemelman, F. J., van Lier, R. A. W., & ten Berge, I. J. M. (2010) · The Journal of Infectious Diseases · doi:10.1086/655472 · Cited by 182
Metadata
- Authors
- Streblow, D. N., Dumortier, J., Moses, A. V., Orloff, S. L., & Nelson, J. A.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Streblow, D. N.
- Venue
- Current Topics in Microbiology and Immunology
- Publisher
- Springer Berlin Heidelberg
- Published
- 2008
- Volume
- 325
- Pages
- 397-415
- ISSN
- 0070-217X (ISSN-L)
- PMC
- PMC2699259
- OpenAlex
- W125742586
- Cited by
- 125
- References
- 65
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 8 · 2015: 6 · 2014: 10 · 2013: 11 · 2012: 15
- FWCI
- 38.67
- Type
- book chapter
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current topics in microbiology and immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs
- American Heart Association
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL 66238-01, R01HL083194, R01HL071695, HL 083194, R01HL065754, HL65754, R01HL085451, HL71695, R01HL066238, R01HL088603)
- National Institute of Allergy and Infectious Diseases (AI21640, R37AI021640, R01AI021640)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- human cytomegalovirus, vascular disease, chronic rejection, angiogenesis, wound healing, paracrine signaling, secretome, cytokines and growth factors, rat cytomegalovirus, atherosclerosis, restenosis, smooth muscle cell proliferation, ganciclovir
- MeSH terms
- Animals, Cytomegalovirus Infections, Cytomegalovirus, Humans, Sclerosis, Vascular Diseases, Cytokines, Intercellular Signaling Peptides and Proteins, Rats
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