The DOI matches its Crossref record; 160 of the 160 references it cites were found in a registry or an index.
Muscarinic Modulation of Striatal Function and Circuitry
Abstract
Striatal cholinergic interneurons are pivotal modulators of the striatal circuitry involved in action selection and decision making. Although nicotinic receptors are important transducers of acetylcholine release in the striatum, muscarinic receptors are more pervasive and have been more thoroughly studied. In this review, the effects of muscarinic receptor signaling on the principal cell types in the striatum and its canonical circuits will be discussed, highlighting new insights into their role in synaptic integration and plasticity. These studies, and those that have identified new circuit elements driven by activation of nicotinic receptors, make it clear that temporally patterned activity in cholinergic interneurons must play an important role in determining the effects on striatal circuitry. These effects could be critical to the response to salient environmental stimuli that serve to direct behavior.
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“Additionally, it is clear that cholinergic interneurons and their regulation of muscarinic receptor signaling are also critical components in striatum-dependent decision making (see, e.g. (Goldberg et al., 2012)).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Goldberg et al., 2012
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Metadata
- Authors
- Goldberg, J. A., Ding, J. B., & Surmeier, D. J.
- Affiliations
- Northwestern University (US)
- Harvard University (US)
- Corresponding author
- Surmeier, D. James
- Venue
- Handbook of Experimental Pharmacology
- Publisher
- Springer Berlin Heidelberg
- Published
- 2011-11-03
- Issue
- 208
- Pages
- 223-241
- ISSN
- 0171-2004 (ISSN-L)
- 1865-0325
- OpenAlex
- W2171464354
- Semantic Scholar
- 15c6ab832bb2759784b39abb97f6cb5d93ea9bbe
- Cited by
- 150
- References
- 160
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 16 · 2021: 9 · 2020: 14 · 2019: 12 · 2018: 13 · 2017: 10 · 2016: 15 · 2015: 12 · 2014: 10 · 2013: 12 · 2012: 1
- FWCI
- 6.88
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- Locations
- Handbook of experimental pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- muscarinic receptors, striatum, cholinergic interneurons, striatal circuitry, nicotinic acetylcholine receptors, synaptic integration, synaptic plasticity, action selection, decision-making, acetylcholine, salient stimuli
- MeSH terms
- Acetylcholine, Animals, Basal Ganglia, Dystonia, Humans, Interneurons, Neural Pathways, Parkinson Disease, Receptors, Muscarinic, Signal Transduction, Muscarinic Antagonists
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