Cited by 217Bacterial Genetics and BiotechnologyBacterial biofilms and quorum sensingAntimicrobial Resistance in Staphylococcus

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Persister Cells: Molecular Mechanisms Related to Antibiotic Tolerance

Lewis, Kim·2012·Handbook of Experimental Pharmacology

DOI 10.1007/978-3-642-28951-4_8

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Abstract

It is a given that new antibiotics are needed to combat drug-resistant pathogens. However, this is only a part of the need-we actually never had antibiotics capable of eradicating an infection. All pathogens produce a small subpopulation of dormant persister cells that are highly tolerant to killing by antibiotics. Once an antibiotic concentration drops, surviving persisters re-establish the population, causing a relapsing chronic infection. Persisters are especially significant when the pathogen is shielded from the immune system by biofilms, or in sites where the immune components are limited-in the nervous system, the stomach, or inside macrophages.Antibiotic treatment during a prolonged chronic infection of P. aeruginosa in the lungs of patients with cystic fibrosis selects for high-persister (hip) mutants. Similarly, treatment of oral thrush infection selects for hip mutants of C. albicans. These observations suggest a direct causality between persisters and recalcitrance of the disease. It appears that tolerance of persisters plays a leading role in chronic infections, while resistance is the leading cause of recalcitrance to therapy in acute infections. Studies of persister formation in E. coli show that mechanisms of dormancy are highly redundant. Isolation of persisters produced a transcriptome which suggests a dormant phenotype characterized by downregulation of energy-producing and biosynthetic functions. Toxin-antitoxin modules represent a major mechanism of persister formation. The RelE toxin causes dormancy by cleaving mRNA; the HipA toxin inhibits translation by phosphorylating elongation factor Ef-Tu, and the TisB toxin forms a membrane pore, leading to a decrease in pmf and ATP.

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Authors: Lewis, K.
Affiliations: Northeastern University (US)
Corresponding author: Lewis, Kim
ORCID: Lewis, Kim
Venue: Handbook of Experimental Pharmacology
Publisher: Springer Berlin Heidelberg
Published: 2012
Issue: 211
Pages: 121-133
ISSN: 0171-2004 (ISSN-L)
1865-0325
DOI: 10.1007/978-3-642-28951-4_8
OpenAlex: W135230180
Cited by: 217
References: 61
Citations by year: 2026: 6 · 2025: 14 · 2024: 8 · 2023: 14 · 2022: 13 · 2021: 13 · 2020: 29 · 2019: 24 · 2018: 16 · 2017: 19 · 2016: 17 · 2015: 18 · 2014: 11 · 2013: 14 · 2012: 1
FWCI: 34.62
Type: book chapter
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Handbook of experimental pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Keywords: persister cells, antibiotic tolerance, bacterial dormancy, toxin-antitoxin systems, chronic infection, biofilm, cystic fibrosis, Pseudomonas aeruginosa, Candida albicans, oral candidiasis, Escherichia coli, efflux pumps, membrane potential, infection relapse
MeSH terms: Candida albicans, Cystic Fibrosis, Drug Resistance, Microbial, Escherichia coli, Humans, Pseudomonas aeruginosa

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