Chemical Modification of the Tetracyclines

Rogalski, W.

doi:10.1007/978-3-642-70304-1_5

Cited by 28Microbial Natural Products and BiosynthesisAntibiotics Pharmacokinetics and EfficacyHistorical Medical Research and Treatments

Chemical Modification of the Tetracyclines

Rogalski, W.·1985·Handbook of Experimental Pharmacology

DOI 10.1007/978-3-642-70304-1_5

Open this paper in CoChat — free account

Integrity signals

Registry

Crossref · 10.1007/978-3-642-70304-1_5

Cites

155 of 155 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The face of tetracycline that interacts with rRNA in the primary (and Tet-1) site is also the face where modifications result in a loss of biological activity.
“(iii) The crystal structures show that the face of tetracycline that interacts with the rRNA in the primary (and Tet-1) site is also the face where modifications result in a loss of biological activity (4, 39).”
From Ribosomal Protection Proteins and Their Mechanism ofTetracyclineResistance (2003) · cites this paper as [39]

A Mathematical Contribution to Structure-Activity Studies
Free, S. M., & Wilson, J. W. (1964) · Journal of Medicinal Chemistry · doi:10.1021/jm00334a001 · Cited by 953 · see citing works
Active efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli.
McMurry, L. M., Petrucci, R., & Levy, S. B. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.7.3974 · Cited by 606 · see citing works
The Outer Membrane of Gram-negative Bacteria
Nikaido, H., & Nakae, T. (1980) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/s0065-2911(08)60208-8 · Cited by 588 · see citing works
AUREOMYCIN: A PRODUCT OF THE CONTINUING SEARCH FOR NEW ANTIBIOTICS
Duggar, B. M. (1948) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1948.tb27262.x · Cited by 514 · see citing works
Pharmacokinetic studies on minocycline in man
Macdonald, H., Kelly, R. G., Allen, E. S., Noble, J. F., & Kanegis, L. A. (1973) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1973145852 · Cited by 222 · see citing works
Studies of the Reversible Epimerization Occurring in the Tetracycline Family. The Preparation, Properties and Proof of Structure of Some 4-epi-Tetracyclines
McCormick, J. R. D., Fox, S. M., Smith, L. L., Bitler, B. A., Reichenthal, J., Origoni, V. E., Müller, W. H., Winterbottom, R., & Doerschuk, A. P. (1957) · Journal of the American Chemical Society · doi:10.1021/ja01568a050 · Cited by 193 · see citing works
pH-Partition Behavior of Tetracyclines
Colaizzi, J. L., & Klink, P. R. (1969) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600581003 · Cited by 165 · see citing works
The Structure of Terramycin1,2
Hochstein, F. A., Stephens, C. R., Conover, L. H., Regna, P. P., Pasternack, R. F., Gordon, P. N., Pilgrim, F. J., Brunings, K. J., & Woodward, R. B. (1953) · Journal of the American Chemical Society · doi:10.1021/ja01118a001 · Cited by 160 · see citing works
Bioavailability of Tetracycline and Doxycycline in Fasted and Nonfasted Subjects
Welling, P. G., Koch, P. A., Lau, C. C., & Craig, W. A. (1977) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.11.3.462 · Cited by 142 · see citing works
The Structure of Aureomycin1
Stephens, C. R., Conover, L. H., Pasternack, R. F., Hochstein, F. A., Moreland, W. T., Regna, P. P., Pilgrim, F. J., Brunings, K. J., & Woodward, R. B. (1954) · Journal of the American Chemical Society · doi:10.1021/ja01642a064 · Cited by 117 · see citing works
Plasmid-mediated tetracycline resistance in escherichia coli involves increased efflux of the antibiotic
Ball, P. R., Shales, S. W., & Chopra, I. (1980) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(80)80247-6 · Cited by 108 · see citing works
Susceptibility of Common Pathogenic Bacteria to Seven Tetracycline Antibiotics in Vitro
Steigbigel, N. H., Reed, C. W., & Finland, M. (1968) · The American Journal of the Medical Sciences · doi:10.1097/00000441-196803000-00005 · Cited by 99 · see citing works
The 6-Deoxytetracyclines. VII. Alkylated Aminotetracyclines Possessing Unique Antibacterial Activity
Martell, M. J., & Boothe, J. H. (1967) · Journal of Medicinal Chemistry · doi:10.1021/jm00313a009 · Cited by 90 · see citing works
Chemical-structural properties of tetracycline derivatives. 1. Molecular structure and conformation of the free base derivatives
Stezowski, J. J. (1976) · Journal of the American Chemical Society · doi:10.1021/ja00435a039 · Cited by 89 · see citing works
Ribosome-tetracycline interactions
Tritton, T. R. (1977) · Biochemistry · doi:10.1021/bi00637a029 · Cited by 86 · see citing works
Determination of a Protonation Scheme of Tetracycline Using Nuclear Magnetic Resonance.
Rigler, N. E., Bag, S. P., Leyden, D. E., Sudmeier, J. L., & Reilley, C. N. (1965) · Analytical Chemistry · doi:10.1021/ac60226a022 · Cited by 85 · see citing works
The constitution of monorden, an antibiotic with tranquilising action
McCapra, F., Scott, A. I., Delmotte, P., Delmotte-Plaquée, J., & Bhacca, N. S. (1964) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)90398-8 · Cited by 84 · see citing works
6-Deoxytetracyclines. IV. 1,2 Preparation, C-6 Stereochemistry, and Reactions
Stephens, C. R., Beereboom, J. J., Rennhard, H. H., Gordon, P. N., Murai, K., Blackwood, R. K., & von Wittenau, M. S. (1963) · Journal of the American Chemical Society · doi:10.1021/ja00900a027 · Cited by 77 · see citing works
The total synthesis of dl-6-demethyl-6-deoxytetracycline
Korst, J. J., Johnston, J. D., Butler, K., Bianco, E. J., Conover, L. H., & Woodward, R. B. (1968) · Journal of the American Chemical Society · doi:10.1021/ja01004a041 · Cited by 72 · see citing works
REVERSIBLE ISOMERIZATIONS IN THE TETRACYCLINE FAMILY
Doerschuk, A. P., Bitler, B. A., & McCormick, J. R. D. (1955) · Journal of the American Chemical Society · doi:10.1021/ja01622a085 · Cited by 71 · see citing works
Aspects of the epimerization of certain tetracycline derivatives
Hussar, D. A., Niebergall, P. J., Sugita, E. T., & Doluisio, J. T. (1968) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1968.tb09802.x · Cited by 68 · see citing works
Crystal and molecular structure of 5,12a-diacetyloxytetracycline
DREELE, R. B. V., & Hughes, R. E. (1971) · Journal of the American Chemical Society · doi:10.1021/ja00755a029 · Cited by 67 · see citing works
Chemistry of tetracyclines
Clive, D. L. J. (1968) · Quarterly Reviews Chemical Society · doi:10.1039/qr9682200435 · Cited by 66 · see citing works
The Total Synthesis of 6-Demethyl-6-Deoxytetracycline
Conover, L. H., Butler, K., Johnston, J. D., Korst, J. J., & Woodward, R. B. (1962) · Journal of the American Chemical Society · doi:10.1021/ja00875a063 · Cited by 66 · see citing works
THE DETERMINATION OF AUREOMYCIN IN SERUM AND OTHER BODY FLUIDS
Dornbush, A. C., & Pelcak, E. J. (1948) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1948.tb27265.x · Cited by 64 · see citing works
Proton nuclear magnetic resonance study of the site of metal binding in tetracycline
Williamson, D. E., & EVERETT, G. W. J. (1975) · Journal of the American Chemical Society · doi:10.1021/ja00842a015 · Cited by 63 · see citing works
Tetracyclines. 9. Total synthesis of dl-terramycin
Muxfeldt, H., Haas, G. W., Hardtmann, G. E., Kathawala, F., Mooberry, J. B., & Vedējs, E. (1979) · Journal of the American Chemical Society · doi:10.1021/ja00497a035 · Cited by 63 · see citing works
Tetracyclines. V.1 A Total Synthesis of (±)-6-Deoxy-6-demethyltetracycline
Muxfeldt, H., & Rogalski, W. (1965) · Journal of the American Chemical Society · doi:10.1021/ja01082a056 · Cited by 61 · see citing works
Self-citation
The tetracyclines: prospects at the beginning of the 1980s
Chopra, I., Howe, T. G. B., Linton, A. H., Linton, K. B., Richmond, M. H., & Speller, D. C. E. (1981) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/8.1.5 · Cited by 60 · see citing works
Some Observations on the Kinetics of the C∙4 Epimerization of Tetracycline
Remmers, E. G., Sieger, G. M., & Doerschuk, A. P. (1963) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600520809 · Cited by 60 · see citing works
A New Reagent for Dehydrating Primary Amides Under Mild Conditions
Stephens, C. R., Bianco, E. J., & Pilgrim, F. J. (1955) · Journal of the American Chemical Society · doi:10.1021/ja01611a102 · Cited by 59 · see citing works
Synthesis of 7-dimethylamino-6-demethyl-6-deoxytetracycline (minocycline) via 9-nitro-6-demethyl-6-deoxytetracycline
Church, R. F. R., Schaub, R. E., & Weiss, M. J. (1971) · The Journal of Organic Chemistry · doi:10.1021/jo00804a025 · Cited by 57 · see citing works
Determination of the Structure of the Vanadium Compound, Amavadine, from Fly Agaric
Kneifel, H., & Bayer, E. (1973) · Angewandte Chemie International Edition in English · doi:10.1002/anie.197305081 · Cited by 57 · see citing works
The Crystal Structure of Aureomycin (Chlortetracycline) Hydrochloride. Configuration, Bond Distances and Conformation
Donohue, J., Dunitz, J. D., Trueblood, K. N., & Webster, M. S. (1963) · Journal of the American Chemical Society · doi:10.1021/ja00890a003 · Cited by 57 · see citing works
Chemical-structural properties of tetracycline derivatives. 2. Coordination and conformational aspects of oxytetracycline metal ion complexation
Jogun, K. H., & Stezowski, J. J. (1976) · Journal of the American Chemical Society · doi:10.1021/ja00435a040 · Cited by 56 · see citing works
Tetracyclines. VII. Total synthesis of dl-terramycin
Muxfeldt, H., Hardtmann, G. E., Kathawala, F., Vedējs, E., & Mooberry, J. B. (1968) · Journal of the American Chemical Society · doi:10.1021/ja01025a063 · Cited by 54 · see citing works
Pharmacokinetics Molecular Modification: Implications in Drug Design Evaluation
Notari, R. E. (1973) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600620602 · Cited by 53 · see citing works
Structure–Activity Relationships in the Tetracycline Series
Blackwood, R. K., & English, A. R. (1970) · Advances in applied microbiology · doi:10.1016/s0065-2164(08)70405-2 · Cited by 53 · see citing works
Chemical-structural properties of tetracycline derivatives. 7. Evidence for the coexistence of the zwitterionic and nonionized forms of the free base in solution
Hughes, L. J., Stezowski, J. J., & Hughes, R. E. (1979) · Journal of the American Chemical Society · doi:10.1021/ja00520a003 · Cited by 52 · see citing works
2-Acetyl-2-decarboxamidoöxytetracycline
Hochstein, F. A., von Wittenau, M. S., Tanner, F. W., & Murai, K. (1960) · Journal of the American Chemical Society · doi:10.1021/ja01507a034 · Cited by 49 · see citing works
Tetracyclines. 10. Chemical-structural properties of tetracycline derivatives. 5. A total synthesis and structural aspects of racemic 8-oxygenated tetracyclines
Glatz, B., Helmchen, G., Muxfeldt, H., Porcher, H., Prewo, R., Senn, J., Stezowski, J. J., Stojda, R. J., & White, D. R. (1979) · Journal of the American Chemical Society · doi:10.1021/ja00502a039 · Cited by 48 · see citing works
6-Methylenetetracyclines. III.1 Preparation and Properties2
Blackwood, R. K., Beereboom, J. J., Rennhard, H. H., von Wittenau, M. S., & Stephens, C. R. (1963) · Journal of the American Chemical Society · doi:10.1021/ja00907a010 · Cited by 48 · see citing works
Structure of chelocardin, a novel tetracycline antibiotic
Mitscher, L. A., Juvarkar, J. V., Rosenbrook, W., Andres, W. W., Schenck, J. R., & Egan, R. S. (1970) · Journal of the American Chemical Society · doi:10.1021/ja00723a049 · Cited by 46 · see citing works
Transport of the lipophilic analog minocycline differs from that of tetracycline in susceptible and resistant Escherichia coli strains
McMurry, L. M., Cullinane, J. C., & Levy, S. B. (1982) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.22.5.791 · Cited by 46 · see citing works
Antibacterial activity in mice of minocycline, a new tetracycline.
Gs, R. (1966) · PubMed · Cited by 44 · see citing works
Chemical-structural properties of tetracycline derivatives. 3. The integrity of the conformation of the nonionized free base
Prewo, R., & Stezowski, J. J. (1977) · Journal of the American Chemical Society · doi:10.1021/ja00446a024 · Cited by 43 · see citing works
Quantum Chemical Approach to Structure‐Activity Relationships of Tetracycline Antibiotics
Peradejordi, F., Martin, A. N., & Cammarata, A. (1971) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600600413 · Cited by 42 · see citing works
The 6-Deoxytetracyclines.1 Further Studies on the Relationship between Structure and Antibacterial Activity in the Tetracycline Series
McCormick, J. R. D., Jensen, E. R., Miller, P., & Doerschuk, A. P. (1960) · Journal of the American Chemical Society · doi:10.1021/ja01498a037 · Cited by 42 · see citing works
Carboxamido Derivatives of the Tetracyclines
Gottstein, W. J., Minor, W. F., & Cheney, L. C. (1959) · Journal of the American Chemical Society · doi:10.1021/ja01514a046 · Cited by 42 · see citing works
How many genes are required for the synthesis of chlortetracycline?
Vaněk, Z., Cudlin, J., Blumauerová, M., & Hošťálek, Z. (1971) · Folia Microbiologica · doi:10.1007/bf02884211 · Cited by 41 · see citing works
TWO NEW TETRACYCLINE-RELATED COMPOUNDS: 7-CHLORO-5a(11a)-DEHYDROTETRACYCLINE AND 5a-EPI-TETRACYCLINE. A NEW ROUTE TO TETRACYCLINE
McCormick, J. R. D., Miller, P., Growich, J. A., Sjolander, N. O., & Doerschuk, A. P. (1958) · Journal of the American Chemical Society · doi:10.1021/ja01553a066 · Cited by 41 · see citing works
Proton Magnetic Resonance Spectra of Tetracyclines
von Wittenau, M. S., & Blackwood, R. K. (1966) · The Journal of Organic Chemistry · doi:10.1021/jo01340a519 · Cited by 39 · see citing works
[Tetracycline kinetics in man. Digestive absorption and serum concentration].
Fabre, J., Mílek, E., Kalfopoulos, P., & Mérier, G. (1971) · PubMed · Cited by 38 · see citing works
Chemistry and Structure-Activity Relationships of Amphenone Analogues
Bencze, W. L., & Allen, M. J. (1959) · Journal of Medicinal Chemistry · doi:10.1021/jm50006a001 · Cited by 37 · see citing works
Circular Dichroism Measurements of the Tetracyclines IV. 5-Hydroxylated Derivatives
Mitscher, L. A., Slater-Eng, B., & Sokoloski, T. D. (1972) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.2.2.66 · Cited by 37 · see citing works
Isolation and Characterization of Two New Tetracycline Antibiotics1
Miller, M. W., & Hochstein, F. A. (1962) · The Journal of Organic Chemistry · doi:10.1021/jo01054a053 · Cited by 36 · see citing works
6-METHYLENETETRACYCLINES.1 I. A NEW CLASS OF TETRACYCLINE ANTIBIOTICS
Blackwood, R. K., Beereboom, J. J., Rennhard, H. H., von Wittenau, M. S., & Stephens, C. R. (1961) · Journal of the American Chemical Society · doi:10.1021/ja01473a043 · Cited by 36 · see citing works
Chemistry of the Tetracycline Antibiotics.1 I. Quaternary Derivatives
Boothe, J. H., Bonvicino, G. E., Waller, C. W., Petisi, J. P., Wilkinson, R. W., & Broschard, R. B. (1958) · Journal of the American Chemical Society · doi:10.1021/ja01540a036 · Cited by 35 · see citing works
The Stereochemistry at C-5 in Oxytetracycline
von Wittenau, M. S., Blackwood, R. K., Conover, L. H., Glauert, R. H., & Woodward, R. B. (1965) · Journal of the American Chemical Society · doi:10.1021/ja01079a034 · Cited by 35 · see citing works
Strategy of Drug Design: A Molecular Guide to Biological Activity
Cheng, C. (1975) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600640438 · Cited by 33 · see citing works
Simulation of the Biosynthesis of Tetracyclines. A Partial Synthesis of Tetracycline from Anhydroaureomycin
Scott, A. I., & Bedford, C. T. (1962) · Journal of the American Chemical Society · doi:10.1021/ja00870a061 · Cited by 32 · see citing works
Determination of Anhydrotetracycline and 4-Epianhydrotetracycline in a Tetracycline Mixture
Kelly, R. G. (1964) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600531234 · Cited by 31 · see citing works
Tetracycline: Chemie, Biochemie und Struktur‐Wirkungs‐Beziehungen
Dürckheimer, W. (1975) · Angewandte Chemie · doi:10.1002/ange.19750872103 · Cited by 31 · see citing works
Synthesis of 12a-deoxy-5a,6-anhydrotetracycline. The first total synthesis of the naturally occuring tetracycline
Gurevich, A. I., Karapetyan, M. G., Kolosov, M. N., Korobko, V. G., Onoprienko, V. V., Popravko, S. A., & Shemyakin, M. M. (1967) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)90501-x · Cited by 30 · see citing works
The total synthesis of a tetracycline
Woodward, R. B. (1963) · Pure and Applied Chemistry · doi:10.1351/pac196306040561 · Cited by 29 · see citing works
pH—Partition Behavior of Amino Acid-Like β-Lactam Antibiotics
Purich, E. D., Colaizzi, J. L., & Poust, R. I. (1973) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600620403 · Cited by 29 · see citing works
Circular dichroism and solution conformation of the tetracycline antibiotics.
Mitscher, L. A., Bonacci, A. C., & Sokoloski, T. D. (1968) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)75384-6 · Cited by 29 · see citing works
Carbon-13 nuclear magnetic resonance analysis of the metal binding site in tetracycline
Gulbis, J., & EVERETT, G. W. J. (1975) · Journal of the American Chemical Society · doi:10.1021/ja00854a052 · Cited by 29 · see citing works
The 6-Deoxytetracyclines. III. Electrophilic and Nucleophilic Substitution
Hlavka, J. J., Schneller, A. J., Krazinski, H. M., & Boothe, J. H. (1962) · Journal of the American Chemical Society · doi:10.1021/ja00867a018 · Cited by 29 · see citing works
Photochemistry IV. A Photodeamination
Hlavka, J. J., & Bitha, P. (1966) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)99977-0 · Cited by 27 · see citing works
Metal binding characteristics of tetracycline derivatives in DMSO solution
Gulbis, J., & EVERETT, G. W. J. (1976) · Tetrahedron · doi:10.1016/0040-4020(76)85048-x · Cited by 27 · see citing works
TOTAL SYNTHESIS OF TETRACYCLINES. I. (±)-DEDIMETHYLAMINO-12a-DEOXY-6-DEMETHYLANHYDROCHLOROTETRACYCLINE
Boothe, J. H., Kende, A. S., Fields, T. L., & Wilkinson, R. G. (1959) · Journal of the American Chemical Society · doi:10.1021/ja01513a062 · Cited by 27 · see citing works
6-Deoxytetracyclines. III. Stereochemistry at C.6
von Wittenau, M. S., Beereboom, J. J., Blackwood, R. K., & Stephens, C. R. (1962) · Journal of the American Chemical Society · doi:10.1021/ja00872a037 · Cited by 26 · see citing works
FURTHER 6-DEOXYTETRACYCLINE STUDIES: EFFECT OF AROMATIC SUBSTITUENTS ON BIOLOGICAL ACTIVITY
Beereboom, J. J., Ursprung, J. J., Rennhard, H. H., & Stephens, C. R. (1960) · Journal of the American Chemical Society · doi:10.1021/ja01489a064 · Cited by 26 · see citing works
Chemical-structural properties of tetracycline antibiotics. 4. Ring A tautomerism involving the protonated amide substituent as observed in the crystal structure of .alpha.-6-deoxyoxytetracycline hydrohalides
Stezowski, J. J. (1977) · Journal of the American Chemical Society · doi:10.1021/ja00446a025 · Cited by 25 · see citing works
EPITETRACYCLINE—THE CHEMICAL RELATIONSHIP BETWEEN TETRACYCLINE AND “QUATRIMYCIN”
Stephens, C. R., Conover, L. H., Gordon, P. N., Pennington, F. C., Wagner, R. L., Brunings, K. J., & Pilgrim, F. J. (1956) · Journal of the American Chemical Society · doi:10.1021/ja01588a071 · Cited by 25 · see citing works
Biosynthesis of tetracyclines. X. Protetrone
McCormick, J. R. D., & Jensen, E. R. (1968) · Journal of the American Chemical Society · doi:10.1021/ja01027a045 · Cited by 24 · see citing works
The crystal structure of terramycin hydrochloride, C22H24N2O9· HCl*
Cid-Dresdner, H. (1965) · Zeitschrift für Kristallographie · doi:10.1524/zkri.1965.121.2-4.170 · Cited by 24 · see citing works
Chemistry of the Tetracycline Antibiotics. III. 12a-Deoxytetracycline
Green, A., & Boothe, J. H. (1960) · Journal of the American Chemical Society · doi:10.1021/ja01500a039 · Cited by 23 · see citing works
6-Deoxytetracyclines. II. Nitrations and Subsequent Reactions
Petisi, J. P., Spencer, J. L., Hlavka, J. J., & Boothe, J. H. (1962) · Journal of Medicinal Chemistry · doi:10.1021/jm01238a014 · Cited by 23 · see citing works
ON THE NATURE OF THE REVERSIBLE ISOMERIZATIONS OCCURRING IN THE TETRACYCLINE FAMILY
McCormick, J. R. D., Fox, S. M., Smith, L. L., Bitler, B. A., Reichenthal, J., Origoni, V. E., Müller, W. H., Winterbottom, R., & Doerschuk, A. P. (1956) · Journal of the American Chemical Society · doi:10.1021/ja01595a084 · Cited by 22 · see citing works
Synthesis of Tetracycline Analogs
Barrett, G. C. (1963) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600520403 · Cited by 22 · see citing works
THE CRYSTAL STRUCTURE OF TERRAMYCIN HYDROCHLORIDE
Takeuchi, Y., & Buerger, Μ. J. (1960) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.46.10.1366 · Cited by 22 · see citing works
CHEMICAL HYDROXYLATION OF 12a-DEOXYTETRACYCLINE
Holmlund, C. E., Andres, W. W., & Shay, A. J. (1959) · Journal of the American Chemical Society · doi:10.1021/ja01526a078 · Cited by 22 · see citing works
The crystal structure of aureomycin hydrochloride
Hirokawa, S., Okaya, Y., Lovell, F. M., & Pepinsky, R. (1959) · Zeitschrift für Kristallographie · doi:10.1524/zkri.1959.112.1-6.439 · Cited by 21 · see citing works
6-DEOXYTETRACYCLINES. I. CHEMICAL MODIFICATION BY ELECTROPHILIC SUBSTITUTION
Boothe, J. H., Hlavka, J. J., Petisi, J. P., & Spencer, J. L. (1960) · Journal of the American Chemical Society · doi:10.1021/ja01490a057 · Cited by 21 · see citing works
Quantitative Structure Pharmacokinetic Activity Relationships with Some Tetracyclines
Toon, S., & Rowland, M. (1979) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1979.tb11591.x · Cited by 20 · see citing works
Cshemistry of hexamethyldisilazane. Silylation of β-diketones and amination of β-triketones
Chu, D. T. W., & Huckin, S. N. (1980) · Canadian Journal of Chemistry · doi:10.1139/v80-022 · Cited by 19 · see citing works
Proposed partition mechanism of tetracycline.
Terada, H., & Inagi, T. (1975) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.23.1960 · Cited by 19 · see citing works
Tetracycline, II. Synthese des Desdimethylamino‐anhydro‐aureomycins
Muxfeldt, H., & Kreutzer, A. (1961) · Chemische Berichte · doi:10.1002/cber.19610940404 · Cited by 18 · see citing works
6-Deoxytetracyclines. V.1a 7,9-Disubstituted Products
Spencer, J. L., Hlavka, J. J., Petisi, J. P., Krazinski, H. M., & Boothe, J. H. (1963) · Journal of Medicinal Chemistry · doi:10.1021/jm00340a014 · Cited by 18 · see citing works
Some Transformations at the 12a-Position in the Tetracycline Series 1
Blackwood, R. K., Rennhard, H. H., & Stephens, C. R. (1960) · Journal of the American Chemical Society · doi:10.1021/ja01504a041 · Cited by 18 · see citing works
Total Synthesis of Tetracyclines. IV. Synthesis of an Anhydrotetracycline Derivative
Kende, A. S., Fields, T. L., Boothe, J. H., & Kushner, S. (1961) · Journal of the American Chemical Society · doi:10.1021/ja01463a044 · Cited by 18 · see citing works
Total Synthesis of Tetracyclines. V. The Stereospecific Elaboration of the Tetracycline Ring System
Fields, T. L., Kende, A. S., & Boothe, J. H. (1961) · Journal of the American Chemical Society · doi:10.1021/ja01483a026 · Cited by 18 · see citing works
SOME TRANSFORMATIONS OF TETRACYCLINE AT THE 4-POSITION
Blackwood, R. K., & Stephens, C. R. (1965) · Canadian Journal of Chemistry · doi:10.1139/v65-187 · Cited by 17 · see citing works
Simple methylation of amides
Bernardi, L. R., Castiglione, R., & Scarponi, U. (1975) · Journal of the Chemical Society Chemical Communications · doi:10.1039/c39750000320 · Cited by 17 · see citing works
Chemical-structural properties of tetracycline derivatives. 10. The 6-thiatetracyclines
Prewo, R., Stezowski, J. J., & Kirchlechner, R. (1980) · Journal of the American Chemical Society · doi:10.1021/ja00543a020 · Cited by 17 · see citing works
Synthesis of 6-thiatetracycline, a highly active analogue of the antibiotic tetracycline
Kirchlechner, R., & Rogalski, W. (1980) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)71180-4 · Cited by 16 · see citing works
Self-citation
Stability of rolitetracycline in aqueous solution
Hughes, D. W., Wilson, W. L., Butterfield, A. G., & Pound, N. J. (1974) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1974.tb12830.x · Cited by 16 · see citing works
The structure of chromocyclomycin
Berlin, Y. A., Kolosov, M. N., Vasina, I. V., & Yartseva, I. V. (1968) · Chemical Communications (London) · doi:10.1039/c19680000762 · Cited by 16 · see citing works
Structural Requirements for Tetracycline Activity
Brown, J., & Ireland, D. S. (1978) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60483-4 · Cited by 16 · see citing works
The 6-Deoxytetracyclines. IV. A Photochemical Displacement of a Diazonium Group1
Hlavka, J. J., Krazinski, H. M., & Boothe, J. H. (1962) · The Journal of Organic Chemistry · doi:10.1021/jo01057a501 · Cited by 16 · see citing works
Chemistry of the Tetracycline Antibiotics. II. Bromination of Dedimethylaminotetracyclines
Green, A., Wilkinson, R. G., & Boothe, J. H. (1960) · Journal of the American Chemical Society · doi:10.1021/ja01500a038 · Cited by 16 · see citing works
The 6-Deoxytetracyclines.1 VI. A Photochemical Transformation
Hlavka, J. J., & Krazinski, H. M. (1963) · The Journal of Organic Chemistry · doi:10.1021/jo01040a528 · Cited by 16 · see citing works
Radioactive 7-Iodo-6-Deoxytetracycline in Tumour Tissue
Hlavka, J. J., & Buyske, D. A. (1960) · Nature · doi:10.1038/1861064b0 · Cited by 15 · see citing works
Novel C-4 Modified Tetracycline Derivatives
Blackwood, R. K., & Stephens, C. R. (1964) · Journal of the American Chemical Society · doi:10.1021/ja01067a055 · Cited by 15 · see citing works
Tautomerism of 5a,11a-Dehydro-7-chlorotetracycline. Preparation of 5-Alkoxy-7-chloroanhydrotetracyclines
von Wittenau, M. S., Hochstein, F. A., & Stephens, C. R. (1963) · The Journal of Organic Chemistry · doi:10.1021/jo01044a513 · Cited by 15 · see citing works
Chemical-structural properties of tetracycline derivatives. 9. 7-Chlorotetracycline derivatives with modified stereochemistry
Prewo, R., & Stezowski, J. J. (1980) · Journal of the American Chemical Society · doi:10.1021/ja00543a019 · Cited by 14 · see citing works
SOME TRANSFORMATIONS AT THE 12a-POSITION OF THE TETRACYCLINES
Blackwood, R. K., Rennhard, H. H., & Stephens, C. R. (1960) · Journal of the American Chemical Society · doi:10.1021/ja01488a060 · Cited by 14 · see citing works
Chemical modifications in the tetracycline series.
VALCAVI, U., Brandt, A., Corsi, G., MINOJA, F., & Pascucci, G. (1981) · The Journal of Antibiotics · doi:10.7164/antibiotics.34.34 · Cited by 14 · see citing works
Conformation of tetracycline ring system. Structure of 5,12a-diacetoxytetracycline
Hughes, R. E., Muxfeldt, H., & DREELE, R. B. V. (1971) · Journal of the American Chemical Society · doi:10.1021/ja00733a048 · Cited by 14 · see citing works
Interaction of various tetracyclines with metallic cations in aqueous solutions as measured by by circular dichroism.
Mitscher, L. A., Bonacci, A. C., Slater-Eng, B., Ak, H., & Td, S. (1969) · PubMed · Cited by 14 · see citing works
ChemInform Abstract: TETRACYCLINES. 9. TOTAL SYNTHESIS OF DL‐TERRAMYCIN
Muxfeldt, H., Haas, G. W., Hardtmann, G. E., Kathawala, F., Mooberry, J. B., & Vedējs, E. (1979) · ChemInform · doi:10.1002/chin.197919375 · Cited by 14 · see citing works
Synthesen in der Tetracyclin‐Reihe
Muxfeldt, H. (1962) · Angewandte Chemie · doi:10.1002/ange.19620741302 · Cited by 13 · see citing works
A symposium on the tetracyclines: a major appraisal. Introduction.
Hc, N. (1978) · PubMed · Cited by 12 · see citing works
1,4,9,10-Tetrahydroanthracene from the stepwise reduction of 9,10-dihydroanthracene by lithium in ammonia
Harvey, R. G. (1967) · The Journal of Organic Chemistry · doi:10.1021/jo01277a065 · Cited by 12 · see citing works
Tetracycloxides. I. A New Class of Tetracycline Derivatives
Esse, R. C., Lowery, J. A., Tamorria, C. R., & Sieger, G. M. (1964) · Journal of the American Chemical Society · doi:10.1021/ja01072a056 · Cited by 12 · see citing works
Studies on the binding of tetracycline to ribosomes
Last, J. A. (1969) · Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis · doi:10.1016/0005-2787(69)90657-1 · Cited by 12 · see citing works
Correlation of the Potencies of Tetracyclines in Vitro with a D-Ring Substituent Index
Cammarata, A., Yau, S. J., Collett, J. H., & Martin, A. N. (1970) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)15203-6 · Cited by 11 · see citing works
Dehydrotetracyclines. I. Epimerization at C-6
Martell, M. J., Ross, A. S., & Boothe, J. H. (1967) · Journal of the American Chemical Society · doi:10.1021/ja01001a080 · Cited by 11 · see citing works
TOTAL SYNTHESIS OF TETRACYCLINES. II. STEREOSPECIFIC SYNTHESIS OF (±)-DEDIMETHYLAMINO-6-DEMETHYL-6,12a-DIDEOXY-7-CHLOROTETRACYCLINE
Fields, T. L., Kende, A. S., & Boothe, J. H. (1960) · Journal of the American Chemical Society · doi:10.1021/ja01490a054 · Cited by 11 · see citing works
N-Pyrrolidinomethyltetracyclin. Stabilität in Lösungen und Papierchromatographische Prüfung.
Brunzell, A., Moses, P., Krohn, C., Motzfeldt, K., Theander, O., & Flood, H. (1962) · Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry · doi:10.3891/acta.chem.scand.16-0245 · Cited by 11 · see citing works
Circular dichroism and solution conformation of the tetracycline antibiotics.
Mitscher, L. A., Bonacci, A. C., & Td, S. (1968) · PubMed · Cited by 11 · see citing works
Totalsynthese des Anhydro‐aureomycins
Muxfeldt, H., Döpp, H., Kaufman, J. E., Schneider, J., Hansen, P. E., Sasaki, A., & Geiser, T. (1973) · Angewandte Chemie · doi:10.1002/ange.19730851110 · Cited by 10 · see citing works
FLUOROTETRACYCLINES. I. PERCHLORYL FLUORIDE STUDIES IN THE TETRACYCLINE SERIES
Rennhard, H. H., Blackwood, R. K., & Stephens, C. R. (1961) · Journal of the American Chemical Society · doi:10.1021/ja01473a044 · Cited by 10 · see citing works
The 6-Deoxytetracyclines. IX. Imidomethylation
Martell, M. J., Ross, A. S., & Boothe, J. H. (1967) · Journal of Medicinal Chemistry · doi:10.1021/jm00315a016 · Cited by 9 · see citing works
The Crystal and Molecular Structures of 7-Chloro- and 7-Bromo-4-hydroxytetracycloxide
den Hende, J. H. V. (1965) · Journal of the American Chemical Society · doi:10.1021/ja01082a053 · Cited by 9 · see citing works
Radioactive Tetracycline
André, T., & Ullberg, S. (1957) · Journal of the American Chemical Society · doi:10.1021/ja01559a070 · Cited by 9 · see citing works
Genetic problems of the biosynthesis of tetracycline antibiotics
Hošťálek, Z., Blumauerová, M., & Vaněk, Z. (1974) · Advances in biochemical engineering, biotechnology · doi:10.1007/3-540-06546-6_2 · Cited by 8 · see citing works
Epimerisierung von Mannich-Basen der Tetracyclin-Antibiotika
H�ttenrauch, R., & Keiner, J. A. (1966) · Die Naturwissenschaften · doi:10.1007/bf00602958 · Cited by 8 · see citing works
Tetracycloxides. II. Transformations at the C-4 Position
Esse, R. C., Lowery, J. A., Tamorria, C. R., & Sieger, G. M. (1964) · Journal of the American Chemical Society · doi:10.1021/ja01072a057 · Cited by 8 · see citing works
Oxidative Preparation of 9-Hydroxytetracyclines
Shu, P. (1966) · Journal of the American Chemical Society · doi:10.1021/ja00971a056 · Cited by 8 · see citing works
Synthesen in der tetracyclinreihe, I
Martin, W., Hartung, H., Urbach, H., & Dürckheimer, W. (1973) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)86958-6 · Cited by 7 · see citing works
Chemistry of chelocardin. V. Condensation with amino reagents
Chu, D. T. W., Huckin, S. N., Bernstein, E., Garmaise, D. L., Egan, R. S., & STANASZEK, R. S. (1981) · Canadian Journal of Chemistry · doi:10.1139/v81-110 · Cited by 7 · see citing works
Synthese von 6-oxatetracyclin, einem weiteren heteroanalogen tetracyclin
Kirchlechner, R. (1981) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)90360-0 · Cited by 7 · see citing works
The 6-Deoxytetracyclines. VIII. Acylaminomethylamides
Martell, M. J., Ross, A. S., & Boothe, J. H. (1967) · Journal of Medicinal Chemistry · doi:10.1021/jm00315a043 · Cited by 7 · see citing works
6-Fluorotetracyclines
Bitha, P., Hlavka, J. J., & Boothe, J. H. (1970) · Journal of Medicinal Chemistry · doi:10.1021/jm00295a023 · Cited by 7 · see citing works
Recent Advances in the Chemistry and Biochemistry of Tetracyclines
Money, T., & Scott, A. I. (1968) · Springer eBooks · doi:10.1007/978-1-4899-7315-3_1 · Cited by 6 · see citing works
Antibacterial activity of a new thiatetracycline
Bakhtiar, M., & Selwyn, S. (1983) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/11.3.291 · Cited by 6 · see citing works
Antibacterial activity of a new thiatetracycline antibiotic, thiacycline, in comparison with tetracycline, doxycycline and minocycline
Russell, A. D., & Ahonkhai, I. (1982) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/9.6.445 · Cited by 6 · see citing works
Synthese von 6‐Thia‐minocyclin, einem Thiaanalogon des Antibiotikums Minocyclin
Kirchlechner, R., & Seubert, J. (1982) · Archiv der Pharmazie · doi:10.1002/ardp.19823150608 · Cited by 5 · see citing works
Über die Einhorn‐Reaktion mit Aminosäuren, III
Bernardelli, C., Bucher, G., Lauria, F., Logemann, W., Tosolini, G., & Vita, G. (1967) · Justus Liebig s Annalen der Chemie · doi:10.1002/jlac.19677060127 · Cited by 5 · see citing works
The effects of some tetracyclines on synchronously growing cultures of Escherichia coli B/r
Collett, J. H., Collett, C., Martin, A. N., & Cammarata, A. (1970) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1970.tb12752.x · Cited by 5 · see citing works
Chemistry of Tetracyclines. II. Allotetracycline and Allooxytetracycline
SCHWARZ, J., & Applegate, H. E. (1967) · The Journal of Organic Chemistry · doi:10.1021/jo01279a603 · Cited by 5 · see citing works
Alkoxyalkyltetracyclines
Tamorria, C. R., & Esse, R. C. (1965) · Journal of Medicinal Chemistry · doi:10.1021/jm00330a036 · Cited by 4 · see citing works
Synthesen in der Tetracyclinreihe, II
Urbach, H., Hartung, H., Martin, W., & DUERCKHEIMER, W. (1973) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)87369-x · Cited by 4 · see citing works
Non-ionized 5a-epi-6-oxatetracycline free base
Kollat, P., & Stezowski, J. J. (1982) · Acta Crystallographica Section B · doi:10.1107/s0567740882009297 · Cited by 3 · see citing works
Chemistry of Tetracyclines. I. Mercuric Acetate Oxidation of Tetracycline
SCHWARZ, J., Applegate, H. E., Bouchard, J., & Weisenborn, F. L. (1967) · The Journal of Organic Chemistry · doi:10.1021/jo01279a600 · Cited by 3 · see citing works
ChemInform Abstract: TETRACYCLINE DERIVATIVES PART 1, ESTERS OF 5‐OXYTETRACYCLINES, CHEMISTRY AND BIOLOGICAL ACTIVITY
Bernardi, L. R., DECASTIGLIONE, R., COLONNA, V., MASI, P., & Mazzoleni, R. (1975) · ChemInform · doi:10.1002/chin.197513436 · Cited by 3 · see citing works
4-Hydroxypretetramids
Hlavka, J. J., Bitha, P., & Boothe, J. H. (1968) · Journal of the American Chemical Society · doi:10.1021/ja01006a033 · Cited by 3 · see citing works
ChemInform Abstract: SYNTHESEN IN DER TETRACYCLINREIHE 2. MITT. TOTALSYNTHESE VON D,L‐4‐AMINO‐7‐CHLOR‐2‐N‐METHYLCARBAMYL‐2‐DESCARBAMYL‐4‐DESDIMETHYLAMINO‐6‐DESMETHYL‐6‐DESOXY‐TETRACYCLIN
Urbach, H., Hartung, H., Martin, W., & DUERCKHEIMER, W. (1974) · ChemInform · doi:10.1002/chin.197411504 · Cited by 2 · see citing works
ChemInform Abstract: TETRACYCLINE DERIVATIVES. III. THE 7‐ AND 9‐METHYLTETRACYCLINES. SYNTHESIS AND BIOLOGICAL ACTIVITY
Bernardi, L. R., Castiglione, R., MASI, P., Mazzoleni, R., & SCARPONI, U. (1976) · ChemInform · doi:10.1002/chin.197616388 · Cited by 2 · see citing works
THE PHARMACOLOGY OF CHLORMETHYLENECYLENECYCLINE, A NEW CHLORTETRACYCLINE.
Tubaro, E., & Banci, F. (1964) · PubMed · Cited by 2 · see citing works
N-(3-Phthalidyl)-tetracycline, a New Carboxamido Derivative of Tetracycline
Granatek, E., Kaplan, M. A., & Buckwalter, F. H. (1963) · Journal of Medicinal Chemistry · doi:10.1021/jm00338a027 · Cited by 1 · see citing works
COMPARATIVE IN VITRO STUDIES OF A NEW THIATETRACYCLINE AND THREE EXISTING TETRACYCLINES
Teare, E., Bakhtiar, M., & SELWYN, S. C. (1981) · Cited by 1 · see citing works

Flagged first, then by citations

3 of the 158 references couldn’t be matched to a known paper.

Sorted by citations

Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance
Chopra, I., & Roberts, M. (2001) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.65.2.232-260.2001 · Cited by 4,517 · see citing works
Tetracyclines: Antibiotic action, uptake, and resistance mechanisms
Schnappinger, D., & Hillen, W. (1996) · Archives of Microbiology · doi:10.1007/s002030050339 · Cited by 484 · see citing works
Ribosomal Protection Proteins and Their Mechanism ofTetracyclineResistance
Connell, S. R., Tracz, D. M., Nierhaus, K. H., & Taylor, D. E. (2003) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.12.3675-3681.2003 · Cited by 449 · see citing works
In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines
TESTA, R. T., Petersen, P. J., Jacobus, N. V., Sum, P., LEE, V. J., & Tally, F. P. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.11.2270 · Cited by 121 · see citing works
Chemical and Biological Dynamics of Tetracyclines
Nelson, M. L. (1998) · Advances in Dental Research · doi:10.1177/08959374980120011901 · Cited by 108 · see citing works
Structural requirements of tetracycline-Tet repressor interaction: determination of equilibrium binding constants for tetracycline analogs with the Tet repressor
Degenkolb, J., Takahashi, M., Ellestad, G. A., & Hillen, W. (1991) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.35.8.1591 · Cited by 102 · see citing works
Molecular basis of tetracycline action: identification of analogs whose primary target is not the bacterial ribosome
Rasmussen, B. A., Noller, H. F., Daubresse, G., Oliva, B., Misulovin, Z., Rothstein, D. M., Ellestad, G. A., Gluzman, Y., Tally, F. P., & Chopra, I. (1991) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.35.11.2306 · Cited by 99 · see citing works
Evidence that tetracycline analogs whose primary target is not the bacterial ribosome cause lysis of Escherichia coli
Oliva, B., Gordon, G., McNicholas, P. M., Ellestad, G. A., & Chopra, I. (1992) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.36.5.913 · Cited by 88 · see citing works
Tetracycline analogs whose primary target is not the bacterial ribosome
Chopra, I. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.4.637 · Cited by 78 · see citing works
Exploring the Boundaries of “Practical”: De Novo Syntheses of Complex Natural Product-Based Drug Candidates
Allred, T. K., Manoni, F., & Harran, P. G. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00126 · Cited by 72 · see citing works
Permeation of tetracyclines through membranes of liposomes and Escherichia coli
Sigler, A., Schubert, P., Hillen, W., & Niederweis, M. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01026.x · Cited by 58 · see citing works
Presence of Macrolide‐Lincosamide‐Streptogramin B and Tetracycline Antimicrobials in Swine Waste Treatment Processes and Amended Soil
Zilles, J. L., Shimada, T., Jindal, A., Robert, M., & Raskin, L. M. (2005) · Water Environment Research · doi:10.2175/106143005x41627 · Cited by 48 · see citing works
Donnan Potential across the Outer Membrane of Gram-Negative Bacteria and Its Effect on the Permeability of Antibiotics
Alegun, O., Pandeya, A., Cui, J., Ojo, I., & Wei, Y. (2021) · Antibiotics · doi:10.3390/antibiotics10060701 · Cited by 42 · see citing works
Formation of anhydrotetracycline during a high-temperature treatment of animal-derived feed contaminated with tetracycline
Kühne, M., Hamscher, G., Körner, U., Schedl, D., & Wenzel, S. (2001) · Food Chemistry · doi:10.1016/s0308-8146(01)00230-8 · Cited by 37 · see citing works
Interdisciplinary studies on Coxiella burnetii: From molecular to cellular, to host, to one health research
Bauer, B. U., Knittler, M. R., Andrack, J., Berens, C., Campe, A., Christiansen, B., Fasemore, A. M., Fischer, S. F., Ganter, M., Körner, S., et al. (2023) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2023.151590 · Cited by 35 · see citing works
Enhanced antiparasitic activity of lipophilic tetracyclines: role of uptake
Katiyar, S. K., & Edlind, T. D. (1991) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.35.11.2198 · Cited by 33 · see citing works
Tetracyclines as antiparasitic agents: lipophilic derivatives are highly active against Giardia lamblia in vitro
Edlind, T. D. (1989) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.33.12.2144 · Cited by 22 · see citing works
Sorption Studies of Tetracycline Antibiotics on Hydroxyapatite (001) Surface—A First-Principles Insight
Song, J., Cui, N., Mao, X., Huang, Q., Lee, E., & Jiang, H. B. (2022) · Materials · doi:10.3390/ma15030797 · Cited by 21 · see citing works
Heterologous Catalysis of the Final Steps of Tetracycline Biosynthesis by Saccharomyces cerevisiae
Herbst, E., Lee, A., Tang, Y., Snyder, S. A., & Cornish, V. W. (2021) · ACS Chemical Biology · doi:10.1021/acschembio.1c00259 · Cited by 14 · see citing works
High-Titer Production of the Fungal Anhydrotetracycline, TAN-1612, in Engineered Yeasts
Baldera-Aguayo, P. A., Lee, A., & Cornish, V. W. (2022) · ACS Synthetic Biology · doi:10.1021/acssynbio.2c00116 · Cited by 10 · see citing works
Tetracyclines — extending the atypical spectrum
Grassi, G. (1993) · International Journal of Antimicrobial Agents · doi:10.1016/0924-8579(93)90033-2 · Cited by 8 · see citing works
Bacterial communication and its role as a target for nanoparticlebased antimicrobial therapy
Miller, K. P. (2015) · Scholar Commons (University of South Carolina) · Cited by 8 · see citing works
A Yeast Three Hybrid Assay for Metabolic Engineering of Tetracycline Derivatives
Herbst, E., Baldera-Aguayo, P. A., Lee, H., & Cornish, V. W. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00419 · Cited by 4 · see citing works
The innate resistome of “recalcitrant” Acinetobacter baumannii and the role of nanoparticles in combating these MDR pathogens
Aparna, V., Kesavan, D. K., Su, Z., Wang, S., & Xu, H. (2021) · Applied Nanoscience · doi:10.1007/s13204-021-01877-6 · Cited by 3 · see citing works
Interactions of tetracyclines with RNA
Berens, C. (2001) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8306-1_7 · Cited by 2 · see citing works
Smartphone-based fluorimetric assay for the determination of doxycycline in in-vitro dissolution studies using 96 well-plates
Gougousi, I., Tarara, M., Zacharis, C. K., Tzanavaras, P. D., & Tsogas, G. Z. (2025) · Microchemical Journal · doi:10.1016/j.microc.2025.114464 · Cited by 1 · see citing works
Using Saccharomyces cerevisiae for the Biosynthesis of Tetracycline Antibiotics
Herbst, E. (2019) · doi:10.7916/d8-ek2d-sm38
From marine origin to therapeutics: study of antibacterial potential of coumarin derived compounds- computational approach
Bansode, D. A., Gir, R. M., Sharma, D., Mushtaq, S., & Kour, N. (2026) · Proceedings of the Indian National Science Academy · doi:10.1007/s43538-026-00854-3

Authors: Rogalski, W.
Corresponding author: Rogalski, W.
Venue: Handbook of Experimental Pharmacology
Publisher: Springer Berlin Heidelberg
Published: 1985
Pages: 179-316
ISSN: 0171-2004 (ISSN-L)
1865-0325
DOI: 10.1007/978-3-642-70304-1_5
OpenAlex: W2230785030
Cited by: 28
References: 158
Citations by year: 2026: 1 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 1
FWCI: 0.00
Type: book chapter
Language: en
Open access: closed
Locations: Handbook of experimental pharmacology (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Historical Medical Research and Treatments
Keywords: tetracycline, chemical modification, antibiotic biosynthesis, broad-spectrum antibiotics, infection treatment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Chemical Modification of the Tetracyclines

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks