Cited by 484Antibiotic Resistance in BacteriaDrug Transport and Resistance MechanismsBacterial Genetics and Biotechnology

Tetracyclines: Antibiotic action, uptake, and resistance mechanisms

Schnappinger, Dirk, Hillen, W.·1996·Archives of Microbiology

Abstract

Tetracyclines probably penetrate bacterial cells by passive diffusion and inhibit bacterial growth by interfering with protein synthesis or by destroying the membrane. A growing number of various bacterial species acquire resistance to the bacteriostatic activity of tetracycline. The two widespread mechanisms of bacterial resistance do not destroy tetracycline: one is mediated by efflux pumps, the other involves an EF-G-like protein that confers ribosome protection. Oxidative destruction of tetracycline has been found in a few species. Several efflux transporters, including multidrug-resistance pumps and tetracycline-specific exporters, confer bacterial resistance against tetracycline. Single amino acids of these carrier proteins important for tetracycline transport and substrate specificity have been identified, allowing the mechanism of tetracycline transport to begin to emerge.

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Crossref · 10.1007/s002030050339

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Authors
Schnappinger, D., & Hillen, W.
Affiliations
Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
Venue
Archives of Microbiology
Published
1996-06-24
Volume
165
Issue
6
Pages
359-369
ISSN
  • 0003-9276 (ISSN-L)
  • 0302-8933
  • 1432-072X
OpenAlex
W2033647833
Cited by
484
References
105
Citations by year
2026: 18 · 2025: 22 · 2024: 25 · 2023: 22 · 2022: 13 · 2021: 29 · 2020: 23 · 2019: 25 · 2018: 21 · 2017: 23 · 2016: 22 · 2015: 25 · 2014: 17 · 2013: 22 · 2012: 16
FWCI
2.82
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Bundesministerium für Bildung und Forschung
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
tetracycline, antibiotic resistance, efflux pumps, multidrug resistance, ribosome protection, oxidative degradation, passive diffusion, bacterial membranes, protein synthesis inhibition, substrate specificity
MeSH terms
Escherichia coli, Ribosomes, Tetracycline Resistance, Tetracyclines

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