PEGylated Protein Drugs: Basic Science and Clinical Applications

Comparison of tissue distribution of a PEGylated Radix Ophiopogonis polysaccharide in mice with normal and ischemic myocardium

Lin, X., Wang, Z.-J., Wang, S., Shen, L., Feng, Y., Ruan, K., & De-sheng, X. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2011.07.002 · Cited by 26

Nano-carbohydrates: Synthesis and application in genetics, biotechnology, and medicine

Jebali, A., Nayeri, E. K., Roohana, S., Aghaei, S., Maede, G., Daliri, K., & Fuente, G. (2016) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2016.11.002 · Cited by 26

The role of poly(2-alkyl-2-oxazoline)s in hydrogels and biofabrication

Trachsel, L., Zenobi‐Wong, M., & Benetti, E. M. (2021) · Biomaterials Science · doi:10.1039/d0bm02217a · Cited by 25

Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats

Fang, J., Vanlandingham, M. M., Beland, F. A., Felton, R. P., Maisha, M. P., Olson, G. R., Patton, R. E., Rosenberg, A. S., & da Costa, G. G. (2022) · Toxicology Letters · doi:10.1016/j.toxlet.2022.01.011 · Cited by 23

Cathepsin B-responsive prodrugs for cancer-targeted therapy: Recent advances and progress for clinical translation

Jeon, S. I., Yang, S., Shim, M. K., & Kim, K. (2022) · Nano Research · doi:10.1007/s12274-022-4354-y · Cited by 25

Assessment of behavioural effects of three water-soluble polymers in zebrafish embryos

Nigro, L., Magni, S., Ortenzi, M. A., Gazzotti, S., Signorini, S. G., Sbarberi, R., Torre, C. D., & Binelli, A. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.164843 · Cited by 23

Current challenges and opportunities in nonclinical safety testing of biologics

Kronenberg, S., Baumann, A., de Haan, L., Hinton, H. J., Moggs, J. G., Theil, F., Wakefield, I. D., & Singer, T. (2013) · Drug Discovery Today · doi:10.1016/j.drudis.2013.08.003 · Cited by 23

Adverse vacuolation in multiple tissues in cynomolgus monkeys following repeat-dose administration of a PEGylated protein

Fletcher, A. M., Tellier, P., Douville, J., Mansell, P., Graziano, M. J., Mangipudy, R. S., Brodie, T. A., & Achanzar, W. E. (2019) · Toxicology Letters · doi:10.1016/j.toxlet.2019.09.023 · Cited by 23

Model-based development of an on-column PEGylation process

Pfister, D., Ingold, O., & Morbidelli, M. (2015) · Reaction Chemistry & Engineering · doi:10.1039/c5re00019j · Cited by 22

Laboratory monitoring of new hemostatic agents for hemophilia

Pruthi, R. K. (2015) · Seminars in Hematology · doi:10.1053/j.seminhematol.2015.10.003 · Cited by 22

PEG chain length impacts yield of solid‐phase protein PEGylation and efficiency of PEGylated protein separation by ion‐exchange chromatography: Insights of mechanistic models

Yoshimoto, N., Isakari, Y., Itoh, D., & Yamamoto, S. (2013) · Biotechnology Journal · doi:10.1002/biot.201200325 · Cited by 22

Pharmacokinetics, tissue distribution, excretion, and metabolite profiling of PEGylated rFIX (nonacog beta pegol, N9-GP) in rats

Sternebring, O., Christensen, J. K., & Bjørnsdottir, I. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.06.025 · Cited by 22

Immunological responses to PEGylated proteins

Elsadek, N. E., Lila, A. S. A., & Ishida, T. (2019) · Elsevier eBooks · doi:10.1016/b978-0-444-64081-9.00005-x · Cited by 22

Overview of Polyethylene Glycol-based Materials with a Special Focus on Core-Shell Particles for Drug Delivery Application

Shah, N., Hussain, M., Rehan, T., Khan, A., & Khan, Z. U. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666210910104333 · Cited by 22

Facile synthesis of well-defined hydrophilic polyesters as degradable poly(ethylene glycol)-like biomaterials

Li, X., Li, H., Zhao, Y., Tang, X., Ma, S., Gong, B., & Li, M. (2015) · Polymer Chemistry · doi:10.1039/c5py00762c · Cited by 22

Mono-PEGylated radix ophiopogonis polysaccharide for the treatment of myocardial ischemia

Sun, G., Lin, X., Shen, L., Wu, F., De-sheng, X., Ruan, K., & Feng, Y. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.05.020 · Cited by 22

Monoconjugation of Human Amylin with Methylpolyethyleneglycol

Sisnande, T., Guerreiro, L. H., Braga, R. R., Jotha-Mattos, L., Erthal, L. C. S., Tinoco, P., Ferreira, B. M., & Lima, L. M. T. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138803 · Cited by 21

Conjugation Strategy Strongly Impacts the Conformational Stability of a PEG-Protein Conjugate

Lawrence, P. B., Billings, W. M., Miller, M. B., Pandey, B. K., Stephens, A. R., Langlois, M. I., & Price, J. L. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.6b00349 · Cited by 20

Fractionation of different PEGylated forms of a protein by chromatography using environment-responsive membranes

Yu, D., Shang, X., & Ghosh, R. (2010) · Journal of Chromatography A · doi:10.1016/j.chroma.2010.06.061 · Cited by 20

Affinity for, and localization of, PEG-functionalized silica nanoparticles to sites of damage in an ex vivo spinal cord injury model

Chen, B., Zuberi, M., Borgens, R. B., & Cho, Y. (2012) · Journal of Biological Engineering · doi:10.1186/1754-1611-6-18 · Cited by 20

Gel Electrophoretic Methods for The Analysis of Biosimilar Pharmaceuticals Using The Example of Recombinant Erythropoietin

Reichel, C., & Thevis, M. (2013) · Bioanalysis · doi:10.4155/bio.13.9 · Cited by 19

Granulocyte colony-stimulating factor (GCSF) fused with Fc Domain produced from E. coli is less effective than Polyethylene Glycol-conjugated GCSF

Do, B. H., Kang, H. J., Song, J.-A., Nguyen, M. T., Park, S., Yoo, J., Nguyen, A. N., Kwon, G. G., Jang, J., Jang, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06726-7 · Cited by 19

Pegylated LyeTx I-b peptide is effective against carbapenem-resistant Acinetobacter baumannii in an in vivo model of pneumonia and shows reduced toxicity

Brito, J. C. M., Lima, W. G., Resende, J. M., de Assis, D. C. S., Boff, D., Cardoso, V. N., Amaral, F. A., de Souza-Fagundes, E. M., Fernandes, S. O. A., & de Lima, M. E. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.121156 · Cited by 19

Non-clinical Safety Evaluation of Biotherapeutics – Challenges, Opportunities and new Insights

Blaich, G., Baumann, A., Kronenberg, S., de Haan, L., Ulrich, P. C., Richter, W., Tibbitts, J., Chivers, S., Tarcsa, E., Caldwell, R. G., et al. (2016) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2016.08.012 · Cited by 19

Mixed micelles as drug delivery nanocarriers

Sobczyński, J., & Chudzik-Rząd, B. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813627-0.00009-0 · Cited by 18

PEG–protein conjugates

Turecek, P. L., & Siekmann, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-444-64081-9.00004-8 · Cited by 18

Noncovalent Protection for Direct Synthesis of α-Amino-ω-hydroxyl Poly(ethylene oxide)

Chen, Y., Zhang, P., Liu, S., Pahovnik, D., Žagar, E., Zhao, J., & Zhang, G. (2021) · ACS Macro Letters · doi:10.1021/acsmacrolett.1c00316 · Cited by 17

Biomolecule detection using wheatstone bridge giant magnetoresistance (GMR) sensors based on CoFeB spin-valve thin film

Swastika, P. E., Antarnusa, G., Suharyadi, E., Kato, T., & Iwata, S. (2018) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1011/1/012060 · Cited by 17

Evolution of polymer conjugation to proteins

Zalipsky, S., & Pasut, G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-444-64081-9.00001-2 · Cited by 17

High MW polyethylene glycol prolongs circulation of pegloticase in mice with anti-PEG antibodies

Talkington, A., McSweeney, M. D., Zhang, T., Li, Z., Nyborg, A. C., LaMoreaux, B. D., Livingston, E. W., Frank, J. E., Yuan, H., & Lai, S. K. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.08.051 · Cited by 18

PEGylation for drug delivery to ischemic myocardium: Pharmacokinetics and cardiac distribution of poly(ethylene glycol)s in mice with normal and ischemic myocardium

Sun, G., Lin, X., Hong, Y., Feng, Y., Ruan, K., & De-sheng, X. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.04.010 · Cited by 17

Challenges for PEGylated Proteins and Alternative Half-Life Extension Technologies Based on Biodegradable Polymers

Besheer, A., Liebner, R., Meyer, M., & Winter, G. (2013) · ACS symposium series · doi:10.1021/bk-2013-1135.ch013 · Cited by 17

In vitro and in vivo assessment of delivery of hydrophobic molecules and plasmid DNAs with PEO–PPO–PEO polymeric micelles on cornea

Hsiao, F., Huang, P.-Y., Aoyagi, T., Chang, S., & Liaw, J. (2017) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2017.09.002 · Cited by 16

Selective polymerization of epoxides from hydroxycarboxylic esters: expediting controlled synthesis of α-carboxyl-ω-hydroxyl polyethers

Liu, S., Liu, L., Chen, Y., & Zhao, J. (2020) · Chemical Communications · doi:10.1039/d0cc05632d · Cited by 16

Subchronic toxicity and immunotoxicity of MeO-PEG-poly(D,L-lactic-co-glycolic acid)-PEG-OMe triblock copolymer nanoparticles delivered intravenously into rats

Liao, L., Zhang, M., Liu, H., Zhang, X., Xie, Z., Zhang, Z., Gong, T., & Sun, X. (2014) · Nanotechnology · doi:10.1088/0957-4484/25/24/245705 · Cited by 16

Antidrug antibodies against the polyethylene glycol moiety inhibit the procoagulant activity of therapeutic polyethylene glycolated factor VIII

Pezeshkpoor, B., Sereda, N., Berkemeier, A., Matuschek, I., Schwarz, N., Turecek, P. L., Horneff, S., Klein, C., Goldmann, G., Marquardt, N., et al. (2023) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2023.03.011 · Cited by 15

Self-Adjuvanting TLR7/8 Agonist and Fentanyl Hapten Co-Conjugate Achieves Enhanced Protection against Fentanyl Challenge

Powers, N., Massena, C., Crouse, B., Smith, M., Hicks, L., Evans, J. T., Miller, S., Pravetoni, M., & Burkhart, D. (2023) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.3c00347 · Cited by 15

The Surface of Protein λ6–85 Can Act as a Template for Recurring Poly(ethylene glycol) Structure

Chao, S.-H., Schäfer, J., & Gruebele, M. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00215 · Cited by 15

Photoenhanced cytosolic protein delivery based on a photocleavable group-modified dendrimer

Li, Y., Zhou, Y., Wang, T., Long, K., Zhang, Y., & Wang, W. (2021) · Nanoscale · doi:10.1039/d1nr04430c · Cited by 15

Production, purification and biological characterization of mono-PEGylated anti-IL-17A antibody fragments

Koussoroplis, S. J., Heywood, S. P., Uyttenhove, C., Barilly, C., Snick, J. V., & Rita Vanbever, A. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.06.077 · Cited by 15

Influence of PEGylation on the Strength of Protein Surface Salt Bridges

Xiao, Q., Draper, S. R. E., Smith, M. S., Brown, N. P., Pugmire, N. A. B., Ashton, D. S., Carter, A. J., Lawrence, E. E. K., & Price, J. L. (2019) · ACS Chemical Biology · doi:10.1021/acschembio.9b00432 · Cited by 16

Grazing incidence SANS and reflectometry combined with simulation of adsorbed microgel particles

Kyrey, T., Ganeva, M., Gawlitza, K., Witte, J., von Klitzing, R., Soltwedel, О., Di, Z., Wellert, S., & Holderer, O. (2018) · Physica B Condensed Matter · doi:10.1016/j.physb.2018.03.049 · Cited by 14

Liquid amphiphilic polymer for effective airborne dust suppression

Lee, T., Park, J., Knoff, D. S., Kim, K., & Kim, M. (2019) · RSC Advances · doi:10.1039/c9ra06787f · Cited by 14

The effect of two different polyethylene glycol (PEG) derivatives on the immunological response of PEG grafted pancreatic islets

Aghajani-Lazarjani, H., Vasheghani‐Farahani, E., Shojaosadati, S. A., Hashemi‐Najafabadi, S., Zahediasl, S., Tiraihi, T., & Atyabi, F. (2010) · Journal of Artificial Organs · doi:10.1007/s10047-010-0525-9 · Cited by 14

Surfactant-free polymeric nanoparticles composed of PEG, cholic acid and a sucrose moiety

Crucho, C. I. C., & Barros, M. T. (2014) · Journal of Materials Chemistry B · doi:10.1039/c3tb21632b · Cited by 14

Effect of the excipient concentration on the pharmacokinetics of PM181104, a novel antimicrobial thiazolyl cyclic peptide antibiotic, following intravenous administration to mice

Yemparala, V., Damre, A. A., Manohar, V., Singh, K. S., Mahajan, G., Sawant, S. N., Deokule, T., & Sivaramakrishnan, H. (2014) · Results in Pharma Sciences · doi:10.1016/j.rinphs.2014.09.001 · Cited by 13

Site-Specific, Stoichiometric-Controlled, PEGylated Conjugates of Fibroblast Growth Factor 2 (FGF2) with Hydrophilic Auristatin Y for Highly Selective Killing of Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1 (FGFR1)

Krzyścik, M. A., Zakrzewska, M., & Otlewski, J. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00419 · Cited by 13

Fibroblast Growth Factor 2 Conjugated with Monomethyl Auristatin E Inhibits Tumor Growth in a Mouse Model

Krzyścik, M. A., Zakrzewska, M., Sørensen, V., Øy, G. F., Brunheim, S., Haugsten, E. M., Mælandsmo, G. M., Więdłocha, A., & Otlewski, J. (2021) · Biomacromolecules · doi:10.1021/acs.biomac.1c00662 · Cited by 13

Evaluation of pharmacokinetics and pharmacodynamics and clinical efficacy of certolizumab pegol for Crohn’s disease

Tun, G. S. Z., & Lobo, A. (2015) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2015.995166 · Cited by 13

Rheumatoid arthritis: basic pathophysiology and role of chitosan nanoparticles in therapy

Kumar, V., Kanwar, J. R., & Verma, A. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819666-3.00016-x · Cited by 13

The Power of Shielding: Low Toxicity and High Transfection Performance of Cationic Graft Copolymers Containing Poly(2-oxazoline) Side Chains

Trützschler, A., Buś, T., Sahn, M., Traeger, A., Weber, C., & Schubert, U. S. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b00362 · Cited by 13

Neutron Reflectometry Elucidates Protein Adsorption from Human Blood Serum onto PEG Brushes

Latza, V. M., Rodriguez-Loureiro, I., Kiesel, I., Halperin, A., Fragneto, G., & Schneck, E. (2017) · Langmuir · doi:10.1021/acs.langmuir.7b03048 · Cited by 12

Arrhenius-model-based degradable oligourethane hydrogels for controlled growth factor release

Tawagi, E., Ung, T. W.-M., Cheng, H. M., & Santerre, J. P. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.05.024 · Cited by 12

Preparation of the Sm3+-Doped Magnetic Nanoparticles via Microwave-Assisted Polyol Synthesis

Lastovina, T. A., Efimova, S. A., Kudryavtsev, E. A., & Soldatov, A. V. (2016) · BioNanoScience · doi:10.1007/s12668-016-0385-8 · Cited by 12

Fast and reliable quantification of busulfan in blood plasma using two-channel liquid chromatography tandem mass spectrometry: Validation of assay performance in the presence of drug formulation excipients

Andersen, A., Bergan, S., Gedde‐Dahl, T., Buechner, J., & Vethe, N. T. (2021) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2021.114216 · Cited by 12

Screening of Reducing Agents for the PEGylation of Recombinant Human IL-10

Ambrogelly, A., Cutler, C., & Paporello, B. (2013) · The Protein Journal · doi:10.1007/s10930-013-9491-4 · Cited by 12

A reactive continuous chromatographic process for protein PEGylation

Ingold, O., Pfister, D., & Morbidelli, M. (2016) · Reaction Chemistry & Engineering · doi:10.1039/c5re00055f · Cited by 12

Preparation and investigation of high solid content PTX-loaded nanoparticles dispersion via nanoprecipitation method

Xiang, Y., Xiao, M., Han, S., Xu, S., Cao, Y., Lv, Z., Liu, J., Liu, J., Deng, L., & Dong, A. (2014) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2014.923365 · Cited by 11

The molar hydrodynamic volume changes of factor VIIa due to GlycoPEGylation

Plesner, B., Westh, P., Hvidt, S., & Nielsen, A. D. (2011) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2011.02.028 · Cited by 11

Charge changing phosphorylated polymers: Proof of in situ mucoadhesive properties

Bonengel, S., Jelkmann, M., Oh, S., Mahmood, A., Ijaz, M., & Bernkop‐Schnürch, A. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.06.011 · Cited by 11

Preparation and Applications of Dendronized Polymer–Enzyme Conjugates

Küchler, A., Messmer, D., Schlüter, A. D., & Walde, P. (2017) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2017.01.014 · Cited by 11

Modification with polysialic acid–PEG copolymer as a new method for improving the therapeutic efficacy of proteins

Wu, J., Lu, S., Zheng, Z., Zhu, L., & Zhan, X. (2016) · Preparative Biochemistry & Biotechnology · doi:10.1080/10826068.2015.1135463 · Cited by 10

Towards improving the biocompatibility of prosthetic eyes

Pine, K. R., Silva, K. D., Zhang, F., Yeoman, J. P., & Jacobs, R. J. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e06234 · Cited by 10

Structure and function of a dual antagonist of the human growth hormone and prolactin receptors with site-specific PEG conjugates

Basu, R., Brody, R., Sandbhor, U., Kulkarni, P., Davis, E., Swegan, D., Caggiano, L. J., Brenya, E., Neggers, S. J. C. M. M., & Kopchick, J. J. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105030 · Cited by 10

A thiol functionalized cryogel as a solid phase for selective reduction of a cysteine residue in a recombinant human growth hormone variant

Jespersen, G. R., Matthiesen, F., Pedersen, A. K., Andersen, H. S., Kirsebom, H., & Nielsen, A. L. (2014) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2013.12.015 · Cited by 10

Process Analytical Technology Application for Protein PEGylation Using near Infrared Spectroscopy: G‐CSF as a Case Study

Hebbi, V., Thakur, G., & Rathore, A. S. (2021) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2020.10.006 · Cited by 10

Immobilization of Xylanase on Poly (Ethylene Glycol) Methyl Ether 5000 and its Self-Extractive Bioconversion for the Production of Xylo-Oligosaccharides

Li, X., Shan, Z., Song, X., Ouyang, J., Xu, Y. Q., Yong, Q., & Yu, S. (2013) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-013-0666-4 · Cited by 10

Interpolyelectrolyte Complexes as an Emerging Technology for Pharmaceutical Delivery of Polypeptides

Fay, J. M., & Kabanov, A. V. (2022) · Reviews and Advances in Chemistry · doi:10.1134/s2634827622600177 · Cited by 10

Synthesis of 4-aminobenzoic acid esters of polyethylene glycol and their use for pegylation of therapeutic proteins

Лоншаков, Д. В., Sheremet’ev, S. V., Белослудцева, Е. М., Korovkin, S. A., Semchenko, A. V., & Katlinskij, A. V. (2015) · RSC Advances · doi:10.1039/c5ra04950d · Cited by 9

Development of Dioctadecyldimethylammonium Bromide/Monoolein Liposomes for Gene Delivery

Silva, J. P. N., Oliveira, A. C., C., A., & Oliveir, M. E. C. D. R. (2012) · InTech eBooks · doi:10.5772/48603 · Cited by 9

pH‐Responsive Polyacetal–Protein Conjugates Designed for Polymer Masked–Unmasked Protein Therapy (PUMPT)

Rodríguez-Escalona, G., Sanchis, J., & Vicent, M. J. (2017) · Macromolecular Bioscience · doi:10.1002/mabi.201700302 · Cited by 9

Statistical analysis of the effects of polyethylene glycol concentration and molecular weight on the sedimentation and resuspendability behavior of model aqueous dispersions

Zhu, W., Vermeir, L., Govoreanu, R., Verbruggen, K., Ariën, T., & der Meeren, P. V. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.06.004 · Cited by 8

Novel mono-PEGylated dimeric GLP-1 conjugate with enhanced receptor activation and prolonged anti-diabetes efficacies

Li, P., Zhang, J., Jia, Y., & Zhang, Y. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117752 · Cited by 8

Improvement of Drug Therapy by Covalent PEG Conjugation: An Overview From a Research Laboratory

Pasut, G., & Veronese, F. M. (2010) · Israel Journal of Chemistry · doi:10.1002/ijch.201000019 · Cited by 8

Polymeric tube-shaped devices with controlled geometry for programmed drug delivery

Park, M., Park, C. G., Lee, S. H., Lee, J. E., Cho, E., Prausnitz, M. R., & Choy, Y. B. (2012) · Macromolecular Research · doi:10.1007/s13233-012-0140-0 · Cited by 8

Amphiphilic diblock copolymer of hydrophilic-functionalized lactone and lactide via switchable organocatalytic polymerization

Bai, J., Tang, X., Zhang, Y., Lin, J., & Li, M. (2018) · RSC Advances · doi:10.1039/c7ra12843f · Cited by 7

Stability of starch-folic acid/ polyethylene glycol particles for gastrointestinal drug delivery

Villela, K. S. V., Betancourt‐Galindo, R., Espinosa‐Neira, R., Espinosa-Solís, V., & García‐Casillas, P. E. (2024) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2024.110318 · Cited by 7

The effect of GlycoPEGylation on the physical stability of human rFVIIa with increasing calcium chloride concentration

Plesner, B., Westh, P., & Nielsen, A. D. (2011) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.12.037 · Cited by 7

Toxicity and biocompatibility of nanomaterials: In vivo studies

Darbasizadeh, B., Feyzi-barnaji, B., & Naderi, N. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90792-7.00014-2 · Cited by 7

Evaluating the in vivo stability of water-soluble PEG-PLA copolymers using FRET imaging

Bou, S., Ng, F., Guégain, E., Peloso, C., López‐Noriega, A., & Collot, M. (2023) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2023.105579 · Cited by 7

Non-invasive methods of monitoring Fe3O4 magnetic nanoparticle toxicity in human liver HepaRG cells using impedance biosensing and Coherent anti-Stokes Raman spectroscopic (CARS) microscopy

Kuhn, J., McDonald, A., Mongoin, C., Anderson, G., Lafeuillade, G., Mitchell, S., Elfick, A. P. D., Bagnaninchi, P., Yiu, H. H. P., & Nelson, L. J. (2024) · Toxicology Letters · doi:10.1016/j.toxlet.2024.02.010 · Cited by 6

Current Strategies for Pharmacokinetic Optimization

Binder, U., & Skerra, A. (2015) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-1-4939-2543-8_14 · Cited by 6

Association of Polyethylene Glycol Solubility with Emerging Membrane Technologies, Wastewater Treatment, and Desalination

Du, H., Bandara, S., Carson, L. E., & Kommalapati, R. R. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.89060 · Cited by 6

Design, synthesis and characterization of a PEGylated stanozolol for potential therapeutic applications

Vergallo, C., Torrieri, G., Provenzani, R., Miettinen, S., Moslova, K., Varjosalo, M. T., Cristiano, M. C., Fresta, M., Celia, C., Santos, H. A., et al. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118826 · Cited by 6

Synthesis of spin labeled ethylene glycol based polymers and study of their segmental motion

Naveed, K., Wang, L., Yu, H., Teng, L., Uddin, M. A., Fahad, S., Ullah, R. S., Nazir, A., & Elshaarani, T. (2020) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2020.128528 · Cited by 6

Oligomeric Poly(ethylene oxide)s. Functionalized Poly(ethylene glycol)s. PEGylation

Dimitrov, I. V., & Tsvetanov, C. B. (2012) · Elsevier eBooks · doi:10.1016/b978-0-444-53349-4.00101-1 · Cited by 7

Advances in interleukin-10-based therapies for pulmonary diseases: focus on targeted lung delivery systems

Tian, W., Wang, X., Zeng, J., Gao, Y., Tang, S., Ma, C., Ye, L., & Tian, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1630990 · Cited by 6

Synthetic Glycopolymers in Tumor Immunotherapy

Chen, Y., Song, J., Chen, X., & Chen, G. (2025) · Macromolecular Rapid Communications · doi:10.1002/marc.202401089 · Cited by 5

Discovery in polyethylene glycol immunogenicity: The characteristic of intergenerational inheritance of anti-polyethylene glycol IgG

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