Involvement of Human Peroxisomes in Biosynthesis and Signaling of Steroid and Peptide Hormones

Peroxisomes are signaling platforms for antiviral innate immunity

Dixit, E., Boulant, S., Zhang, Y.-J., Lee, A. S., Odendall, C., Shum, B. O. V., Hacohen, N., Chen, Z.-J. J., Whelan, S. P. J., Fransen, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.04.018 · Cited by 848 · see citing works

PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.

Benjannet, S., Rondeau, N., Day, R. W., Chrétien, M., & Seidah, N. G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3564 · Cited by 588 · see citing works

Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms

Chiang, J. Y. L. (2003) · Journal of Hepatology · doi:10.1016/j.jhep.2003.11.006 · Cited by 550 · see citing works

Genetic Analysis of Indole-3-butyric Acid Responses inArabidopsis thalianaReveals Four Mutant Classes

Zolman, B. K., Yoder, A. R., & Bartel, B. (2000) · Genetics · doi:10.1093/genetics/156.3.1323 · Cited by 290 · see citing works

Peroxisomal alterations in Alzheimer’s disease

Kou, J., Kovacs, G. G., Höftberger, R., Kulik, W., Brodde, A., Forss-Petter, S., Hönigschnabl, S., Gleiss, A., Brügger, B., Wanders, R., et al. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0836-9 · Cited by 227 · see citing works

Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus

Facciotti, F., Ramanjaneyulu, G. S., Lepore, M., Sansano, S., Cavallari, M., Kistowska, M., Forss‐Petter, S., Ni, G., Colone, A., Singhal, A., et al. (2012) · Nature Immunology · doi:10.1038/ni.2245 · Cited by 208 · see citing works

X-linked adrenoleukodystrophy: Clinical, biochemical and pathogenetic aspects

Berger, J., & Gärtner, J. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.07.010 · Cited by 199 · see citing works

Endogenous opioids: overview and current issues

Akil, H., Owens, C. E., Gutstein, H. B., Taylor, L. P., Curran, E. J., & Watson, S. J. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00071-4 · Cited by 180 · see citing works

Purification and characterization of the prohormone convertase PC1(PC3).

Zhou, Y., & Lindberg, I. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53365-2 · Cited by 166 · see citing works

Bile acids: the role of peroxisomes

Ferdinandusse, S., Denis, S. W., Faust, P. L., & Wanders, R. J. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r900009-jlr200 · Cited by 136 · see citing works

IBR3, a novel peroxisomal acyl-CoA dehydrogenase-like protein required for indole-3-butyric acid response

Zolman, B. K., Nyberg, M., & Bartel, B. (2007) · Plant Molecular Biology · doi:10.1007/s11103-007-9134-2 · Cited by 123 · see citing works

Neuropeptide Processing and Its Impact on Melanocortin Pathways

Pritchard, L. E., & White, A. (2007) · Endocrinology · doi:10.1210/en.2006-1686 · Cited by 113 · see citing works

Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes

Kovacs, W. J., Tape, K. N., Shackelford, J. E., Duan, X., Kasumov, T., Kelleher, J. K., Brunengraber, H., & Krisans, S. K. (2006) · Histochemistry and Cell Biology · doi:10.1007/s00418-006-0254-6 · Cited by 84 · see citing works

A correlative study of the adrenal cortex in adreno-leukodystrophy--evidence for a fatal intoxication with very long chain saturated fatty acids.

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Peroxisomes, Refsum's disease and the α- and ω-oxidation of phytanic acid

Wanders, R. J. A., & Komen, J. C. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350865 · Cited by 69 · see citing works

Two Activation States of the Prohormone Convertase PC1 in the Secretory Pathway

Jutras, I., Seidah, N. G., Reudelhuber, T. L., & Brechler, V. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15184 · Cited by 68 · see citing works

Mevalonate kinase is a cytosolic enzyme in humans

Hogenboom, S., Tuyp, J. J. M., Espeel, M., Koster, J., Wanders, R. J. A., & Waterham, H. R. (2004) · Journal of Cell Science · doi:10.1242/jcs.00910 · Cited by 59 · see citing works

Testicular dysfunction in adrenomyeloneuropathy

Brennemann, W., Köhler, W., Zierz, S., & Klingmüller, D. (1997) · European Journal of Endocrinology · doi:10.1530/eje.0.1370034 · Cited by 50 · see citing works

The role of peroxisomal ABC transporters in the mouse adrenal gland: the loss of Abcd2 (ALDR), Not Abcd1 (ALD), causes oxidative damage

Lu, J., Barron‐Casella, E. A., Brose, R. D., Heinzer, A. K., Moser, A. B., Bentley, K. L. D. M., Wand, G. S., McGuinness, M. C., Pei, Z., Watkins, P. A., et al. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700512 · Cited by 48 · see citing works

Phosphomevalonate kinase is a cytosolic protein in humans

Hogenboom, S., Tuyp, J. J. M., Espeel, M., Koster, J., Wanders, R. J. A., & Waterham, H. R. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300373-jlr200 · Cited by 47 · see citing works

Internalization and nuclear localization of peptide hormones

Morel, G. (1994) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)90438-3 · Cited by 38 · see citing works

Reproductive function in men affected by X-linked adrenoleukodystrophy/adrenomyeloneuropathy

Stradomska, T. J., Kubalska, J., Janas, R. M., & Tylki‐Szymańska, A. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0490 · Cited by 25 · see citing works

Effect of dehydroepiandrosterone supplementation on fatty acid and hormone levels in patients with X‐linked adrenoleucodystrophy

Assies, J., Haverkort, E. B., Lieverse, R., & Vreken, P. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01868.x · Cited by 17 · see citing works

Cellular Trafficking of Exogenous Growth Hormone in Dwarf Rat Pituitary

Mertani, H. C., Waters, M. J., & Morel, G. (2008) · Neuroendocrinology · doi:10.1159/000126965 · Cited by 17 · see citing works

Is subclinical adrenal failure in adrenoleukodystrophy/adrenomyeloneuropathy reversible

Cappa (2011) · PubMed · doi:10.3275/7570 · Cited by 14 · see citing works

Peroxisomal Localization of the Proopiomelanocortin-Derived Peptides β-Lipotropin and β-Endorphin

Höftberger, R., Kunze, M., Voigtländer, T., Unterberger, U., Regelsberger, G., Bauer, J., Aboul‐Enein, F., Garzuly, F., Forss‐Petter, S., Bernheimer, H., et al. (2010) · Endocrinology · doi:10.1210/en.2010-0249 · Cited by 12 · see citing works

β-Lipotropin-stimulated adrenal steroid production

O'Connell, Y., McKenna, T. J., & Cunningham, S. K. (1996) · Steroids · doi:10.1016/0039-128x(96)00002-5 · Cited by 8 · see citing works

Testosterone metabolites in patients reduce the levels of very long chain fatty acids accumulated in X-adrenoleukodystrophic fibroblasts

Petroni, A., Papini, N., Blasevich, M., Magnaghi, V., Cavarretta, I. T. R., Galli, C. L., & Melcangi, R. C. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01296-9 · Cited by 8 · see citing works

Adrenal steroids in adrenomyeloneuropathy

Wichers, M., Grigull, A., Sokolowski, P., Stoffel‐Wagner, B., & Köhler, W. (2005) · Journal of Neurology · doi:10.1007/s00415-005-0908-7 · Cited by 7 · see citing works

The role of lipotropins as hematopoietic factors and their potential therapeutic use

Bucay, A. H. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.02.001 · Cited by 4 · see citing works

Organelle-specific regulation of ferroptosis

Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00859-z · Cited by 401 · see citing works

ACBD2/ECI2-Mediated Peroxisome-Mitochondria Interactions in Leydig Cell Steroid Biosynthesis

Fan, J., Li, X., Issop, L., Culty, M., & Papadopoulos, V. (2016) · Molecular Endocrinology · doi:10.1210/me.2016-1008 · Cited by 99 · see citing works

Ferroptosis mechanisms and regulations in cardiovascular diseases in the past, present, and future

Fang, W., Xie, S., & Deng, W. (2024) · Cell Biology and Toxicology · doi:10.1007/s10565-024-09853-w · Cited by 78 · see citing works

The diversity of ACBD proteins – From lipid binding to protein modulators and organelle tethers

Islinger, M., Costello, J. L., Kors, S., Soupène, E., Levine, T. P., Kuypers, F. A., & Schrader, M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118675 · Cited by 55 · see citing works

Mitochondrial free radical theory of aging: Who moved my premise?: MFRTA: Who moved my premise?

Liu, Y., Long, J., & Liu, J. (2014) · Geriatrics & Gerontology International · doi:10.1111/ggi.12296 · Cited by 27 · see citing works

Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy

Bougnères, P., & Le Stunff, C. (2025) · Genes · doi:10.3390/genes16050590 · Cited by 11 · see citing works

Peroxisome Protein Prediction in Drosophila melanogaster

Anderson‐Baron, M., & Simmonds, A. J. (2018) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-2233-4_10 · Cited by 6 · see citing works

Gene Therapy of Adrenomyeloneuropathy: Challenges, Target Cells, and Prospectives

Bougneres, P. F., Stunff, C. L., & Badin, R. A. (2025) · Biomedicines · doi:10.3390/biomedicines13081892 · Cited by 1 · see citing works

Peroxisomal Localization of the Proopiomelanocortin-Derived Peptides β-Lipotropin and β-Endorphin

Höftberger, R., Kunze, M., Voigtländer, T., Unterberger, U., Regelsberger, G., Bauer, J., Aboul‐Enein, F., Garzuly, F., Forss‐Petter, S., Bernheimer, H., et al. (2010) · Endocrinology · doi:10.1210/en.2010-0249 · Cited by 12 · see citing works

Untitled work

(1997) · doi:10.1002/(sici)1097-0029(19970315)36:6

Peroxisomes: A Nexus for Lipid Metabolism and Cellular Signaling

Lodhi, I. J., & Semenkovich, C. F. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.002 · Cited by 605 · see citing works

Lipid metabolism in peroxisomes in relation to human disease

Wanders, R. J. A., & Tager, J. M. (1998) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(98)00003-x · Cited by 122 · see citing works

Peroxisomes, Lipid Metabolism, and Human Disease

Wanders, R. J. A. (2000) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:32:1-3:89 · Cited by 45 · see citing works