The Benzodiazepines

Marks, John

doi:10.1007/978-94-011-6203-6

Cited by 92Synthesis and pharmacology of benzodiazepine derivativesHistorical Medical Research and TreatmentsHistorical Psychiatry and Medical Practices

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The Benzodiazepines

Marks, John·1978·Springer eBooks

DOI 10.1007/978-94-011-6203-6

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Refractoriness to treatment is the lack of response to a previously effective pharmacological treatment when it is started again after a drug-free period.
“Refractoriness to treatment is the lack of response to a previously effective pharmacological treatment when it is started again after a drug-free period [25]”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [25]
Loss of clinical effects involves the return of symptoms during maintenance treatment that only temporarily respond to dose increase.
“Loss of clinical effects involves the return of symptoms during maintenance treatment that only temporarily respond to dose increase [25].”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [25]

Sorted by citations

Withdrawal Reaction after Long-Term Therapeutic Use of Benzodiazepines
Busto, U., Sellers, E. M., Naranjo, C. A., Cappell, H., Sanchez-Craig, M., & Sykora, K. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610023151403 · Cited by 369
Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications
Cosci, F., & Chouinard, G. (2020) · Psychotherapy and Psychosomatics · doi:10.1159/000506868 · Cited by 265
Current Status of Benzodiazepines
Koch‐Weser, J., Greenblatt, D. J., Shader, R. I., & Abernethy, D. R. (1983) · New England Journal of Medicine · doi:10.1056/nejm198308113090607 · Cited by 248
Benzodiazepines in the treatment of schizophrenia: a review and reappraisal
Wolkowitz, O. M., & Pickar, D. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.6.714 · Cited by 219
Precipitated Withdrawal by a Benzodiazepine Receptor Antagonist (Ro 15-1788) After 7 Days of Diazepam
Lukas, S. E., & Griffiths, R. R. (1982) · Science · doi:10.1126/science.6287579 · Cited by 155
Animal models of drug withdrawal symptoms
Emmett‐Oglesby, M. W., Mathis, D. A., Moon, R. T. Y., & Lal, H. (1990) · Psychopharmacology · doi:10.1007/bf02244046 · Cited by 137
Individual Differences in Behavioral and Subjective Responses to Alcohol
de Wit, H., UHLENHUTH, E. H., Pierri, J. N., & Johanson, C. E. (1987) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1987.tb01263.x · Cited by 132
Diazepam-induced place preference conditioning: Appetitive and antiaversive properties
Spyraki, C., Kazandjian, A., & Varonos, D. D. (1985) · Psychopharmacology · doi:10.1007/bf00431813 · Cited by 121
Benzodiazepine Dependency Syndromes
Smith, D. E., & Wesson, D. R. (1983) · Journal of Psychoactive Drugs · doi:10.1080/02791072.1983.10472127 · Cited by 90
Benzodiazepine Withdrawal Syndrome: A Literature Review and Evaluation
Mackinnon, G. L., & Parker, W. A. (1982) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952998209002608 · Cited by 81
Assessing the Risks and Benefits of Benzodiazepines for Anxiety Disorders in Patients with a History of Substance Abuse or Dependence
Posternak, M. A., & Mueller, T. I. (2001) · American Journal on Addictions · doi:10.1080/105504901750160484 · Cited by 73
Abuse of Benzodiazepines: The Problems and the Solutions
DuPont, R. L. (1988) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952998809020204 · Cited by 74
Objective Determination of Benzodiazepine Use and Abuse in Alcoholics
Busto, U. E., Simpkins, J., Sellers, E. M., Sisson, B., & Segal, R. (1983) · British Journal of Addiction · doi:10.1111/j.1360-0443.1983.tb02531.x · Cited by 65
Are benzodiazepines overused and abused?
Rickels, K. (1981) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1981.tb01842.x · Cited by 61
Tranquillisers as a Social Problem
Gabe, J., & Bury, M. R. (1988) · The Sociological Review · doi:10.1111/j.1467-954x.1988.tb00840.x · Cited by 56
Benzodiazepines in the Treatment of Alcoholism
Nutt, D., Adinoff, B. H., & Linnoila, M. (1989) · Recent developments in alcoholism · doi:10.1007/978-1-4899-1678-5_15 · Cited by 54
The Place of Benzodiazepines in Psychiatric Practice
Tyrer, P. J., & Murphy, S. (1987) · The British Journal of Psychiatry · doi:10.1192/bjp.151.6.719 · Cited by 52
“Even with high dosage, doubt was cast upon the role of benzodiazepines in producing dependence, as in so many published reports alcohol and other addictive drugs were taken as well as benzodiazepines (Marks, 1978).”
Background
Geriatric Psychopharmacology
Zimmer, B., & Grossberg, G. T. (1997) · Critical issues in neuropsychology · doi:10.1007/978-1-4899-1857-4_32 · Cited by 47
An International Overview
Marks, J. (1985) · Springer eBooks · doi:10.1007/978-94-009-4886-0_5 · Cited by 45
Self-citation
Prevalence of Benzodiazepine Abuse and Dependence In-Psychiatric In-Patients with Different Nosology
Schmidt, L. G., Grohmann, R., Müller-Oerlinghausen, B., Otto, M., Rüther, E., & Wolf, B. (1989) · The British Journal of Psychiatry · doi:10.1192/bjp.154.6.839 · Cited by 39
“Compared with prevalence figures of retrospective studies (Fleischhacker eta?, 1986; Laux & KÃ¶nig, 1987) and older large-scale surveys (Greenblatt eta?, 1975; Marks, 1978), the prevalence of primary BZD dependence is much higher in this survey (1% of the hospital population).”
Result
Use of Benzodiazepines in Primary‐care Geriatric Patients
Pinsker, H., & Suljaga-Petchel, K. (1984) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1984.tb06139.x · Cited by 38
The antagonism of benzodiazepine withdrawal effects by the selective cholecystokininB receptor antagonist CI‐988
Singh, L., Field, M. J., Vass, C. A., et al. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb14201.x · Cited by 36
Drug preference in normal volunteers: Effects of age and time of day
de Wit, H., UHLENHUTH, E. H., & Johanson, C. E. (1985) · Psychopharmacology · doi:10.1007/bf00431805 · Cited by 34
Factors influencing the duration of treatment with psychotropic drugs in general practice: a survival analysis approach
Williams, P. R. (1983) · Psychological Medicine · doi:10.1017/s0033291700048030 · Cited by 35
Symptoms of the Barbiturate/Benzodiazepine Withdrawal Syndrome in Healthy Volunteers: Standardized Assessment by a Newly Developed Self-Rating Scale
Merz, W. A., & Ballmer, U. (1983) · Journal of Psychoactive Drugs · doi:10.1080/02791072.1983.10472126 · Cited by 30
Long‐term use of benzodiazepines in psychiatric inpatients
Laux, G., & König, W. (1987) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1987.tb02863.x · Cited by 29
Diazepam tolerance and withdrawal assessed in an animal model of subjective drug effects
Emmett‐Oglesby, M. W., Mathis, D. A., & Lal, H. (1987) · Drug Development Research · doi:10.1002/ddr.430110302 · Cited by 29
Antidepressant properties of the triazolobenzodiazepines alprazolam and adinazolam: studies on the olfactory bulbectomized rat model of depression.
O'Connor, W. T., Earley, B., & Leonard, B. E. (1985) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1985.tb02742.x · Cited by 28
Snorting Benzodiazepines
Sheehan, M. F., Sheehan, D. V., Torres, A., Coppola, A., & Francis, E. M. (1991) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952999109001605 · Cited by 26
Benzodiazepine Withdrawal
Lapierre, Y. D. (1981) · The Canadian Journal of Psychiatry · doi:10.1177/070674378102600203 · Cited by 26
The Benzodiazepines An International Perspective
Marks, J. (1983) · Journal of Psychoactive Drugs · doi:10.1080/02791072.1983.10472135 · Cited by 23
Self-citation
Treatment of Alcohol Withdrawal Syndrome
Özdemir, V., Bremner, K. E., & Naranjo, C. A. (1994) · Annals of Medicine · doi:10.3109/07853899409147336 · Cited by 23
The long‐term use of psychotropic drugs: A follow‐up study in italian general practice
Fiorio, R., Bellantuono, C., Leoncini, M., et al. (1990) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.470050304 · Cited by 15
Benzodiazepine Dependence and Withdrawal
Ayd, F. J. (1983) · Journal of Psychoactive Drugs · doi:10.1080/02791072.1983.10472125 · Cited by 15
The effect of repeated doses of temazepam and nitrazepam on human psychomotor performance.
Tedeschi, G., Griffiths, A., Smith, A., et al. (1985) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1985.tb05078.x · Cited by 14
Some Characteristics Distinguishing High and Low Dose Users of Benzodiazepines
Perera, K. M. H., & Jenner, F. A. (1987) · British Journal of Addiction · doi:10.1111/j.1360-0443.1987.tb00435.x · Cited by 13
Observation Room Therapy for Aggressive Adolescents
Arnold, L. E., TOLBERT, H. A., MOLINARI, V. J., et al. (1980) · American Journal of Psychiatry · doi:10.1176/ajp.137.1.130-b · Cited by 12
Benzodiazepines in Emotional Disorders
Rickels, K. (1983) · Journal of Psychoactive Drugs · doi:10.1080/02791072.1983.10472122 · Cited by 11
Lormetazepam (Lorámet®): A Multicentre Assessment of its Efficacy and Acceptability as a Hypnotic in Out-Patients with Sleep Disturbances
Hill, R. C., & Harry, T. V. A. (1983) · Journal of International Medical Research · doi:10.1177/030006058301100601 · Cited by 7
Benzodiazepines and the Behaviour Therapist: Managing Withdrawal and the Problems of Concurrent Treatment with these Drugs
Miller, E. (1986) · Behavioural Psychotherapy · doi:10.1017/s0141347300012441 · Cited by 7
Elimination Kinetics and Symptomatology of Diazepam Withdrawal in Abusers
Rhodes, P. J., Rhodes, R. S., & McCurdy, H. H. (1984) · Journal of Toxicology Clinical Toxicology · doi:10.3109/15563658408992568 · Cited by 7
Abuse and Dependency:An International Perspective
Smith, D. E., & Marks, J. (1985) · Springer eBooks · doi:10.1007/978-94-009-4886-0_14 · Cited by 7
Self-citation
Toxicology and Side-Effects of Anxiolytics
Lr, H. (1981) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-67767-0_7 · Cited by 7
Principles of Therapeutic Applications of the Benzodiazepines
Hollister, L. E. (1983) · Journal of Psychoactive Drugs · doi:10.1080/02791072.1983.10472120 · Cited by 6
Pentylenetetrazole‐like stimulus is produced in rats during withdrawal from ingested chlordiazepoxide
Idemudia, S. O., & Lal, H. (1989) · Drug Development Research · doi:10.1002/ddr.430160104 · Cited by 6
Entzugssyndrome, Abhängigkeitsrisiko und Intoxikation mit Benzodiazepinen
Poser, W., Poser, S., Piesiur-Strehlow, B., & Eva, P. (1987) · Steinkopff eBooks · doi:10.1007/978-3-642-85358-6_4 · Cited by 5
Buspirone, benzodiazepines, and post‐traumatic stress disorder
Simpson, M. A. (1991) · Journal of Traumatic Stress · doi:10.1002/jts.2490040213 · Cited by 4
CGS 9896 blocks the pentylenetetrazol‐like effect of withdrawal from chronic ethanol
Harris, C. M., Elkhayat, I. S., Benjamin, D., et al. (1989) · Drug Development Research · doi:10.1002/ddr.430160221 · Cited by 4
Small Comfort: The Introduction of Minor Tranquilizers to the Public and the Medical Profession
Smith, M. C. (1988) · Journal of Psychoactive Drugs · doi:10.1080/02791072.1988.10472510 · Cited by 4
Benzodiazepine prescription to middle-aged women
Rosser, W. (1982) · Postgraduate Medicine · doi:10.1080/00325481.1982.11716044 · Cited by 4
Pentobarbital blocks the pentylenetetrazole‐like effect of withdrawal from chronic diazepam
Mathis, D. A., & Emmett‐Oglesby, M. W. (1989) · Drug Development Research · doi:10.1002/ddr.430160222 · Cited by 3
Benzodiazepines
Ananth, J. (1982) · Postgraduate Medicine · doi:10.1080/00325481.1982.11716231 · Cited by 3
Benzodiazepines in Emotional Disorders
Rickels, K. (1985) · Springer eBooks · doi:10.1007/978-94-009-4886-0_7 · Cited by 3
The Use of Benzodiazepines in Anxiety Disorders
Cashman, F. E. (1986) · Springer eBooks · doi:10.1007/978-1-4684-5254-9_12 · Cited by 2
Benzodiazepin-Abusus Epidemiologische und klinisch-klassifikatorische Aspekte
Laux, G., & König, W. (1986) · Springer eBooks · doi:10.1007/978-3-642-70952-4_28 · Cited by 2
Benzodiazepines for panic disorder
Garvey, M. J. (1991) · Postgraduate Medicine · doi:10.1080/00325481.1991.11701088 · Cited by 2
Characteristics and Mechanisms of Tolerance to Benzodiazepines
Леоновна, Г. Т., & Воронина, Т. А. (1986) · Springer eBooks · doi:10.1007/978-1-4684-1656-5_19 · Cited by 1
Ausweich- und Substitutionsmittel
Geschwinde, T. (2018) · Springer eBooks · doi:10.1007/978-3-662-56275-8_4 · Cited by 1
The evaluation of an exhibition about anxiety
Merrett, C., & Eveleigh, C. (1985) · Journal of the Institute of Health Education · doi:10.1080/03073289.1985.10805589 · Cited by 1
Persistent Postwithdrawal Syndrome after Benzodiazepine Discontinuation. A Reply to Huff
Cosci, F., & Chouinard, G. (2021) · Psychotherapy and Psychosomatics · doi:10.1159/000515015 · Cited by 1
Longterm Treatment with Diazepam: Clinical and Electroencephalographic Variables
Ladewig, D., & Schwarz, E. (1980) · Springer eBooks · doi:10.1007/978-94-011-7238-7_18 · Cited by 1
Langzeiteinnahme und Abhängigkeit von Benzodiazepinen Ergebnisse einer epidemiologischen Studie
Laux, G., & König, W. (1986) · Springer eBooks · doi:10.1007/978-3-642-70621-9_26 · Cited by 1
Vital Uses of Diazepam in Third World Countries
Ward, J. S. (1985) · Springer eBooks · doi:10.1007/978-94-009-4886-0_13
Die Ethik der Chemischen Therapie in der Psychiatrie
Burian, W. (1984) · VS Verlag für Sozialwissenschaften eBooks · doi:10.1007/978-3-322-84052-3_6
Ausweich- und Substitutionsmittel
Geschwinde, T. (2012) · Springer eBooks · doi:10.1007/978-3-642-30163-6_4
Fear state induced by diazepam withdrawal may be due to the sensitization of the neural substrates of aversion in the dPAG
Nobre, M. J., & Ross, J. B. D. (2008) · Annals of General Psychiatry · doi:10.1186/1744-859x-7-s1-s144
Употреба на бензодијазепини кај пациенти на метадонски третман
Петрушевска, Т. (2015) · Macedonian Medical Electronic Journal · doi:10.3889/mmej.2015.50006
Maintenance treatment with benzodiazepines
LAUGHREN, T. P. (1980) · American Journal of Psychiatry · doi:10.1176/ajp.137.1.130a
General Aspects of Treatment
Cotterill, J. A., & Finlay, A. Y. (2004) · Wiley eBooks · doi:10.1002/9780470750520.ch71
Atypische Antidepressiva
Laux, G., Delini‐Stula, A., Breyer-Pfaff, U., et al. (1993) · Springer eBooks · doi:10.1007/978-3-7091-3317-0_5
Editorial
(1987) · Stress Medicine · doi:10.1002/smi.2460030402
Observation room therapy for aggressive adolescents
(1980) · American Journal of Psychiatry · doi:10.1176/ajp.137.1.130b
Ausweich- und Substitutionsmittel
(2007) · Springer eBooks · doi:10.1007/978-3-540-72045-4_5
Ausweichmittel
Geschwinde, T. (1997) · Springer eBooks · doi:10.1007/978-3-662-09679-6_5
Literatur
Platz, W. E. (1996) · Deutscher Universitätsverlag eBooks · doi:10.1007/978-3-663-01655-7_10
Literaturverzeichnis
Strian, F. (1983) · Springer eBooks · doi:10.1007/978-3-642-93245-8_9
Ausweichmittel
Geschwinde, T. (1990) · Springer eBooks · doi:10.1007/978-3-662-09680-2_5
Editorial
(1986) · Stress Medicine · doi:10.1002/smi.2460020202
Sedative-Hypnotics
Hollister, L. E. (1981) · Springer eBooks · doi:10.1007/978-1-4615-7740-9_4
Buspirone, benzodiazepines, and post-traumatic stress disorder
Simpson, M. A. (1991) · Journal of Traumatic Stress · doi:10.1007/bf00977012
Literatur
Platz, W. E. (1987) · Vieweg+Teubner eBooks · doi:10.1007/978-3-663-05272-2_6
Letters to the Editor
(1992) · Journal of the Royal Society of Medicine · doi:10.1177/014107689208500833
Benzodiazepine Addiction: A Difficult Story
Bourin, M. (2024) · Springer eBooks · doi:10.1007/978-3-031-72219-6_17
Peut-il y avoir une définition médicale de la crise familiale?
Kahn, J. P., Witkowski, P., & Laxenaire, M. (1989) · The Canadian Journal of Psychiatry · doi:10.1177/070674378903400409
Longterm Treatment with Anxiolytic Drugs: Possibilities of Pharmacodependence
Bueno, J. (1980) · Springer eBooks · doi:10.1007/978-94-011-7238-7_20

Authors: Marks, J.
Affiliations: University of Cambridge (GB)
Corresponding author: Marks, John
Venue: Springer eBooks
Publisher: Springer Netherlands
Published: 1978
DOI: 10.1007/978-94-011-6203-6
OpenAlex: W4238517656
Cited by: 92
References: 0
Citations by year: 2024: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2015: 1 · 2012: 1
FWCI: 3.37
Type: book
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Springer eBooks (publishedVersion)
Topics: Physical Sciences › Chemistry › Organic Chemistry › Synthesis and pharmacology of benzodiazepine derivatives
Health Sciences › Medicine › Pharmacology (medical) › Historical Medical Research and Treatments
Social Sciences › Psychology › Clinical Psychology › Historical Psychiatry and Medical Practices
Keywords: benzodiazepines, history of drug discovery, chemical synthesis, drug development, anxiolytics

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