The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Benzodiazepine Withdrawal
Abstract
As with most psychotropic sedative drugs, the potential for withdrawal reactions is present with the benzodiazepines (19). Signs suggesting the potential for withdrawal reactions can be gleaned from the clinical course of events such as the development of tolerance anc psychological and physiological dependence. If high doses are reached, the risk of withdrawal reactions increases with the length of treatment and the abruptness of cessation. The long-acting benzodiazepines have a built-in mechanism against withdrawal reactions through their active metabolites. Abrupt cessation of drug therapy in high-dose patients should be avoided to reduce the risk of withdrawal reactions.
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Withdrawal symptoms are more severe following withdrawal from short rather than long half-life benzodiazepines.
“These symptoms are more severe following withdrawal from short rather than long half-life BZDs [39,40,41,42,43].”
From Cognitive behavioral therapy and acceptance and commitment therapy for the discontinuation of long-term benzodiazepine use in insomnia and anxiety disorders (2021) · cites this paper as [39]
Citations
Cites
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Benzodiazepines and Withdrawal Psychosis
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Diazepam Maintenance of Alcohol Preference During Alcohol Withdrawal
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Self-citationA Case of Oxazepam (Serenid D) Dependence
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Flagged first, then by citations
Research works printed but not linked: 4
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- Cook L., 1973, The benzodiazepines.
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Cited by
Sorted by citations
Gradual Withdrawal of Diazepam after Long-Term Therapy
Tyrer, P., Owen, R., & Dawling, S. (1983) · The Lancet · doi:10.1016/s0140-6736(83)92355-3 · Cited by 271
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Chapoutot, M., Peter-Derex, L., Bastuji, H., Leslie, W., Schoendorff, B., Heinzer, R., Siclari, F., Nicolas, A., Lemoine, P., Higgins, S., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph181910222 · Cited by 59
Clorazepate and lorazepam: clinical improvement and rebound anxiety
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Benzodiazpine withdrawal effects
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Benzodiazepine Withdrawal: Clinical Aspects
Wright, S. L. (2020) · The Benzodiazepines Crisis · doi:10.1093/med/9780197517277.003.0008 · Cited by 7
Metadata
- Authors
- Lapierre, Y. D.
- Affiliations
- University of Ottawa (CA)
- Corresponding author
- Lapierre, Y.D.
- Venue
- The Canadian Journal of Psychiatry
- Publisher
- SAGE Publications
- Published
- 1981-03
- Volume
- 26
- Issue
- 2
- Pages
- 93-95
- ISSN
- 0706-7437 (ISSN-L)
- 1497-0015
- OpenAlex
- W4249959490
- Cited by
- 26
- References
- 14
- Citations by year
- 2021: 1 · 2020: 1 · 2013: 1 · 2012: 1
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Canadian Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and pharmacology of benzodiazepine derivatives
- Keywords
- benzodiazepine withdrawal, benzodiazepines, drug addiction, tolerance (pharmacology and immunology), withdrawal reactions, long-acting benzodiazepines, bioactive metabolites, sedative-hypnotic drugs
- MeSH terms
- Anxiety, Diazepam, Drug Tolerance, Humans, Sleep Initiation and Maintenance Disorders, Lorazepam, Oxazepam, Substance Withdrawal Syndrome, Time Factors, Anti-Anxiety Agents
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