Regulation of IL-6 in Immunity and Diseases

Inflammation and cancer

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IL‐6 in inflammation, immunity, and disease

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The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome.

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Interleukin-6: from basic science to medicine--40 years in immunology.

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Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.

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Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

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Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

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HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor

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IL‐6 and NF‐IL6 in Acute‐Phase Response and Viral Infection

Akira, S., & Kishimoto, T. (1992) · Immunological Reviews · doi:10.1111/j.1600-065x.1992.tb01407.x · Cited by 531 · see citing works

The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition

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Post-transcriptional control of cytokine production

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Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

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The Biology and Medical Implications of Interleukin-6

Tanaka, T., & Kishimoto, T. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0022 · Cited by 376 · see citing works

The Nuclear Factor-κB Engages CBP/p300 and Histone Acetyltransferase Activity for Transcriptional Activation of the Interleukin-6 Gene Promoter

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Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis

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Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6

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The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR–IL-1R by controlling degradation of regnase-1

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MicroRNA-26a suppresses tumor growth and metastasis of human hepatocellular carcinoma by targeting interleukin-6-Stat3 pathway

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Therapeutic Targeting of the Interleukin-6 Receptor

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The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT protein.

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Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo

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Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3

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Rhinoviruses replicate effectively at lower airway temperatures

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Therapeutic uses of anti-interleukin-6 receptor antibody

Kang, S., Tanaka, T., & Kishimoto, T. (2014) · International Immunology · doi:10.1093/intimm/dxu081 · Cited by 172 · see citing works

STAT3 Induction of miR-146b Forms a Feedback Loop to Inhibit the NF-κB to IL-6 Signaling Axis and STAT3-Driven Cancer Phenotypes

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Hyperactivated NF-κB and AP-1 Transcription Factors Promote Highly Accessible Chromatin and Constitutive Transcription across the Interleukin-6 Gene Promoter in Metastatic Breast Cancer Cells

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HIV-1 Tat Induces the Expression of the Interleukin-6 (IL6) Gene by Binding to the IL6 Leader RNA and by Interacting with CAAT Enhancer-binding Protein β (NF-IL6) Transcription Factors

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A novel mechanism of tumor suppression by destabilizing AU-rich growth factor mRNA

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Heat Shock Transcription Factor 1 Opens Chromatin Structure of Interleukin-6 Promoter to Facilitate Binding of an Activator or a Repressor

Inouye, S., Fujimoto, M., Nakamura, T., Takaki, E., Hayashida, N., Hai, T., & Nakai, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704471200 · Cited by 107 · see citing works

Epigenetic Regulation of the miR142-3p/Interleukin-6 Circuit in Glioblastoma

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Kaposi's Sarcoma-Associated Herpesvirus ORF57 Promotes Escape of Viral and Human Interleukin-6 from MicroRNA-Mediated Suppression

Kang, J., Pripuzova, N. S., Majerčiak, V., Kruhlak, M. J., Le, S., & Zheng, Z. (2011) · Journal of Virology · doi:10.1128/jvi.02144-10 · Cited by 76 · see citing works

Decreased Expression of the Ets Family Transcription Factor Fli-1 Markedly Prolongs Survival and Significantly Reduces Renal Disease in MRL/ lpr Mice

Zhang, X. K., Gallant, S., Molano, I. D., Moussa, O., Ruiz, P., Spyropoulos, D. D., Watson, D. K., & Gilkeson, G. S. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.10.6481 · Cited by 64 · see citing works

Association of interleukin-6 gene polymorphism with coronary artery disease: an updated systematic review and cumulative meta-analysis

Hou, H., Wang, C., Sun, F., Zhao, L., Dun, A., & Sun, Z. (2015) · Inflammation Research · doi:10.1007/s00011-015-0850-9 · Cited by 55 · see citing works

Regulation of the Interleukin-6 gene expression during monocytic differentiation of HL-60 cells by chromatin remodeling and methylation

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Expression of ets family of genes in systemic lupus erythematosus and Sjogren's syndrome

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AT‐Rich–Interactive Domain–Containing Protein 5A Functions as a Negative Regulator of Retinoic Acid Receptor–Related Orphan Nuclear Receptor γt–Induced Th17 Cell Differentiation

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A Critical Role of the Transcription Factor Fli‐1 in Murine Lupus Development by Regulation of Interleukin‐6 Expression

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Interleukin-6; pathogenesis and treatment of autoimmune inflammatory diseases

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Historical overview of the interleukin-6 family cytokine

Kang, S., Narazaki, M., Metwally, H., & Kishimoto, T. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20190347 · Cited by 360 · see citing works

Investigating Immunomodulatory Biomaterials for Preventing the Foreign Body Response

Kim, A., Downer, M. A., Berry, C. E., Valencia, C., Fazilat, A. Z., & Griffin, M. (2023) · Bioengineering · doi:10.3390/bioengineering10121411 · Cited by 38 · see citing works

Interleukin-6 levels in serum, plasma, and cerebral spinal fluid in individuals with suicide behavior: systematic review and meta-analysis with meta-regression

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Discussion on pathogenesis levels of hypertension

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Exploration on relationship of basic pathogenesis and disease symptom

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Analysis of Pathogenesis and Correlative Factors of Acute Upper Gastrointestinal Hemorrhage

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Salt-Dependent Structural Changes of Chromatin in Isolated Chicken Liver Nuclei as Visualized by Scanning Electron Microscopy

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Quantifying Three-Dimensional Chromatin Packing through Electron Tomography

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