The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
Circular RNAs Act as miRNA Sponges
Open accessAbstract
Majority of RNAs expressed in animal cells lack protein-coding ability. Unlike other cellular RNAs, circular (circ)RNAs include a large family of noncoding (nc)RNAs that lack the 5' or 3' ends. The improvements in high-throughput RNA sequencing and novel bioinformatics tools have led to the identification of thousands of circRNAs in various organisms. CircRNAs can regulate gene expression by influencing the transcription, the mRNA turnover, and translation by sponging RNA-binding proteins and microRNAs. Given the broad impact of circRNA on miRNA activity, there is huge interest in understanding the impact of miRNA sponging by circRNA on gene regulation. In this review, we summarize our current knowledge of the miRNA-circRNA interaction and mechanisms that influence gene expression.
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1 retracted
Yu, L., Gong, X., Sun, L., Zhou, Q., Lu, B., & Zhu, L. (2016) · PLOS ONE · doi:10.1371/journal.pone.0158347 · Cited by 356
RetractedCircular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990
Natural RNA circles function as efficient microRNA sponges
Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985
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Li, J.-H., Liu, S., Zhou, H., Qu, L.-H., & Yang, J.-H. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1248 · Cited by 4,686
Circular RNAs are abundant, conserved, and associated with ALU repeats
Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., Liu, J., Marzluff, W. F., & Sharpless, N. E. (2013) · RNA · doi:10.1261/rna.035667.112 · Cited by 4,388
miRBase: integrating microRNA annotation and deep-sequencing data
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Central Dogma of Molecular Biology
CRICK, F. (1970) · Nature · doi:10.1038/227561a0 · Cited by 3,444
Exon-intron circular RNAs regulate transcription in the nucleus
Li, Z., Huang, C., Bao, C., Chen, L., Lin, M., Wang, X., Zhong, G., Yu, B., Hu, W., Dai, L., et al. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2959 · Cited by 2,905
Detecting and characterizing circular RNAs
Jeck, W. R., & Sharpless, N. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2890 · Cited by 2,702
Cited by
Circular RNA: metabolism, functions and interactions with proteins
Zhou, W.-Y., Cai, Z.-R., Liu, J., Wang, D.-S., Ju, H.-Q., & Xu, R.-H. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01286-3 · Cited by 1,427
Targeting circular RNAs as a therapeutic approach: current strategies and challenges
He, A. T., Liu, J., Li, F., & Yang, B. B. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00569-5 · Cited by 549
Chen, X., Jiang, C., Sun, R., Yang, D., & Liu, Q. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.01.010 · Cited by 66
Li, M., Hu, J., Peng, Y., Li, J., & Ren, R. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00305-3 · Cited by 36
Metadata
- Authors
- Panda, A. C.
- Venue
- Advances in Experimental Medicine and Biology
- Publisher
- Springer Singapore
- Published
- 2018
- Volume
- 1087
- Pages
- 67-79
- ISSN
- 0065-2598 (ISSN-L)
- 2214-8019
- OpenAlex
- W2892630678
- Cited by
- 1,109
- References
- 79
- FWCI
- 113.23
- Type
- book chapter
- Language
- en
- Open access
- hybrid
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