The DOI matches its Crossref record; 161 of the 161 references it cites were found in a registry or an index.
Circular RNA: metabolism, functions and interactions with proteins
Open accessAbstract
Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important advances have been made in the biogenesis, regulation, localization, degradation and modification of circRNAs. CircRNAs exert biological functions by acting as transcriptional regulators, microRNA (miR) sponges and protein templates. Moreover, emerging evidence has revealed that a group of circRNAs can serve as protein decoys, scaffolds and recruiters. However, the existing research on circRNA-protein interactions is quite limited. Hence, in this review, we briefly summarize recent progress in the metabolism and functions of circRNAs and elaborately discuss the patterns of circRNA-protein interactions, including altering interactions between proteins, tethering or sequestering proteins, recruiting proteins to chromatin, forming circRNA-protein-mRNA ternary complexes and translocating or redistributing proteins. Many discoveries have revealed that circRNAs have unique expression signatures and play crucial roles in a variety of diseases, enabling them to potentially act as diagnostic biomarkers and therapeutic targets. This review systematically evaluates the roles and mechanisms of circRNAs, with the hope of advancing translational medicine involving circRNAs.
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1 retracted
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Self-citationRetractedCircular RNAs are a large class of animal RNAs with regulatory potency
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Circular RNAs are abundant, conserved, and associated with ALU repeats
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Qin, S., Tang, X., Chen, Y., Chen, K., Fan, N., Xiao, W., Zheng, Q., Li, G., Teng, Y., Wu, M., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01007-w · Cited by 771
Circular RNA vaccine in disease prevention and treatment
Niu, D., Wu, Y., & Lian, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01561-x · Cited by 267
Zhang, X.-Y., Li, S.-S., Gu, Y.-R., Xiao, L.-X., Ma, X.-Y., Chen, X.-R., Wang, J.-L., Liao, C.-H., Lin, B.-L., Huang, Y.-H., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02030-x · Cited by 80
Functions of Circular RNA in Human Diseases and Illnesses
Gu, A., Jaijyan, D. K., Yang, S., Zeng, M., Pei, S., & Zhu, H. (2023) · Non-Coding RNA · doi:10.3390/ncrna9040038 · Cited by 65
Lin, Z., Lv, D., Liao, X., Peng, R., Liu, H., Wu, T., Wu, K., Sun, Y., & Zhang, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1226962 · Cited by 39
Metadata
- Authors
- Zhou, W.-Y., Cai, Z.-R., Liu, J., Wang, D.-S., Ju, H.-Q., & Xu, R.-H.
- Venue
- Molecular Cancer
- Published
- 2020-12
- Volume
- 19
- Issue
- 1
- Pages
- 172-172
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W3112047397
- Cited by
- 1,427
- References
- 161
- FWCI
- 39.83
- Type
- journal article
- Language
- en
- Open access
- gold
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