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Chitosan Chemistry: Relevance to the Biomedical Sciences
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“Chitosan is a natural, biodegradable, biocompatible, and non-toxic biopolymer obtained from chitin deacetylation that is sourced from the exo-skeleton of crustaceans (Muzzarelli and Muzzarelli, 2005; Lizardi-Mendoza et al., 2016).”
From GRAS, plant- and animal-derived compounds as alternatives to conventional fungicides for the control of postharvest diseases of fresh horticultural produce (2016) · cites this paper as Muzzarelli and Muzzarelli, 2005
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Isolation of lysozyme on chitosan
Muzzarelli, R. A. A., Barontini, G., & Rochetti, R. (1978) · Biotechnology and Bioengineering · doi:10.1002/bit.260200107 · Cited by 34
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Carboxymethyl chitosan: Properties and biomedical applications
Shariatinia, Z. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.09.131 · Cited by 777
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RetractedA review on chitosan-based flocculants and their applications in water treatment.
Yang, R., Li, H., Huang, M., Yang, H., & Li, A.-M. (2016) · Water Research · doi:10.1016/j.watres.2016.02.068 · Cited by 691
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Liu, J., Willför, S. M., & Xu, C. (2014) · Bioactive Carbohydrates and Dietary Fibre · doi:10.1016/j.bcdf.2014.12.001 · Cited by 641
“…of chitin/chitosan has been extensively developed, e.g. in oral administration for lowering serum cholesterol concentration and hypertension and in ophthalmic preparations for improving the retention and biodistribution of drugs applied topically onto the eyes (Muzzarelli & Muzzarelli, 2005).”
Marine Polysaccharides in Pharmaceutical Applications: An Overview
Laurienzo, P. (2010) · Marine Drugs · doi:10.3390/md8092435 · Cited by 538
Chitosan Based Scaffolds and Their Applications in Wound Healing
Ahmed, S., & Ikram, S. (2016) · Achievements in the Life Sciences · doi:10.1016/j.als.2016.04.001 · Cited by 516
Chitosan Modification and Pharmaceutical/Biomedical Applications
Zhang, J.-L., Xia, W., Liu, P., Cheng, Q.-Y., Tahirou, T., Gu, W.-X., & Li, B. (2010) · Marine Drugs · doi:10.3390/md8071962 · Cited by 495
Sosnik, A., das Neves, J., & Sarmento, B. F. C. C. (2014) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2014.07.010 · Cited by 495
Marine Derived Polysaccharides for Biomedical Applications: Chemical Modification Approaches
d’Ayala, G. G., Malinconico, M., & Laurienzo, P. (2008) · Molecules · doi:10.3390/molecules13092069 · Cited by 516
“Among the many chemical derivatives of chitosan mentioned in literature [120], one can differentiate specific reaction involving the –NH2 group at the C-2 position or non-specific reactions of –OH groups at C-3 and C-6 positions (especially esterification and etherification).”
BackgroundBiomaterials for Bone Tissue Engineering
Chen, Q. (2013) · Humana Press eBooks · doi:10.1007/978-1-62703-417-3_23 · Cited by 341
Pillai, C. K. S., & Sharma, C. P. (2010) · Journal of Biomaterials Applications · doi:10.1177/0885328210384890 · Cited by 375
Mohan, K., Ganesan, A. R., Muralisankar, T., Rajarajeswaran, J., Sathishkumar, P., Uthayakumar, V., Chandirasekar, R., & Revathi, N. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.08.016 · Cited by 370
“This finding demonstrates that the antibacterial effects of insect chitosan can also be used as active edible packaging in food applications (Hamed et al., 2016; R.; Muzzarelli & Muzzarelli, 2005).”
BackgroundUtilization of by-products and treatment of waste in the food industry
Oreopoulou, V., & Ruß, W. (2007) · Springer eBooks · doi:10.1007/978-0-387-35766-9 · Cited by 307
Bone tissue engineering scaffolding: computer-aided scaffolding techniques
Thavornyutikarn, B., Chantarapanich, N., Sitthiseripratip, K., Thouas, G. A., & Chen, Q. (2014) · Progress in Biomaterials · doi:10.1007/s40204-014-0026-7 · Cited by 326
“In addition to the enhanced osteoconductivity (the process in which growth of bone on the biomaterial surface) in vivo, chitosan also exhibits an ability to entrap growth factors at the wound site (Muzzarelli et al. 1993; Muzzarelli and Muzzarelli 2005).”
Kumirska, J., Weinhold, M., Thöming, J., & Stepnowski, P. (2011) · doi:10.3390/polym3041875 · Cited by 286
“Chitin and chitosan possess very interesting biological properties (Figure 2); therefore, they have been used in many applications, mainly in the medical and pharmaceutical fields [4,17,19,21-30].”
BackgroundPalou, L., Ali, A., Fallik, E., & Romanazzi, G. (2016) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2016.04.017 · Cited by 286
Yan, H., Yang, L., Yang, Z., Yang, H., Li, A.-M., & Cheng, R.-S. (2012) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2012.06.014 · Cited by 284
Chitosan Amphiphilic Derivatives. Chemistry and Applications
Aranaz, I., Harris, R., & Heras, Á. (2010) · Current Organic Chemistry · doi:10.2174/138527210790231919 · Cited by 273
“Chitosan is a non-toxic, biodegradable and biocompatible polymer, which presents very interesting biological properties as shown in Table 1 [3-17].”
BackgroundChitosan composites with inorganics, morphogenetic proteins and stem cells, for bone regeneration
Muzzarelli, R. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.10.044 · Cited by 270
Self-citationMuzzarelli, R., Mehtedi, M. E., Bottegoni, C., Aquili, A., & Gigante, A. (2015) · Marine Drugs · doi:10.3390/md13127068 · Cited by 268
“The advances made become quite noticeable when the works dated 2010–2015 (amounting to >82% of the bibliography below) are compared to some most significant key articles [5,11,27,41,50,141–146] published in the 2000–2005 quinquennium.”
BackgroundResultSelf-citationZhou, Y., Fu, S., Zhang, L., Zhan, H., & Levit, M. V. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.08.055 · Cited by 300
“It is derived by deacetylation of chitin, the second most abundant natural polymer in the world (Muzzarelli & Muzzarelli, 2005; Varma, Deshpande, & Kennedy, 2004).”
BackgroundRecent advances in carboxymethyl chitosan-based materials for biomedical applications
Geng, Y., Xue, H., Zhang, Z., Panayi, A. C., Knoedler, S. A., Zhou, W., Mi, B., & Liu, G. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120555 · Cited by 288
Strategies to improve chitosan hemocompatibility: A review
Bălan, V., & Vereștiuc, L. (2014) · European Polymer Journal · doi:10.1016/j.eurpolymj.2014.01.033 · Cited by 251
“immunoadjuvant and antitumor activity, hemostatic, fungistatic, spermicidal, anticholesteremic, [125,127,34], pro-”
Fonseca‐Santos, B., & Chorilli, M. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.03.198 · Cited by 272
Bukzem, A. L., Signini, R., Santos, D. D. D., Lião, L., & Ascheri, D. P. R. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.01.017 · Cited by 233
“5, it is insoluble in neutral water and in common organic solvents[2].”
Stanish, W., McCormack, R., Forriol, F., Mohtadi, N., Pelet, S., Desnoyers, J., Restrepo, A., & Shive, M. (2013) · Journal of Bone and Joint Surgery. American volume · doi:10.2106/jbjs.l.01345 · Cited by 231
Developments and application of chitosan-based adsorbents for wastewater treatments
Bhatt, P., Joshi, S., Urper‐Bayram, G. M., Khati, P., & Şimşek, H. (2023) · Environmental Research · doi:10.1016/j.envres.2023.115530 · Cited by 273
Mati‐Baouche, N., Elchinger, P., de Baynast, H., Pierre, G., Delattre, C., & Michaud, P. (2014) · European Polymer Journal · doi:10.1016/j.eurpolymj.2014.09.008 · Cited by 242
Piekarska, K., Sikora, M., Owczarek, M., Jóźwik-Pruska, J., & Wiśniewska‐Wrona, M. (2023) · Polymers · doi:10.3390/polym15040793 · Cited by 269
“The source of chitin, its proper es and the conditions of the deacetylation process (temperature, time and c ncentration of alkalis) have a significant impact on the chemic l purity and quality of pa ameters related to the biol gical activity and technological usefulness of chitosan [25].”
BackgroundInfluentialOptimum conditions for lipase immobilization on chitosan-coated Fe3O4 nanoparticles
Kuo, C.-H., Liu, Y.-C., Chang, C.-M. J., Chen, J.-H., Chang, C., & Shieh, C. (2012) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2011.11.026 · Cited by 202
Zhang, C., Qu, G.-W., Sun, Y., Wu, X., Yao, Z., Guo, Q.-L., Ding, Q.-L., Yuan, S., Shen, Z.-L., Ping, Q.-N., et al. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2007.11.029 · Cited by 196
“Among them, chitosan, a polysaccharide derived from chitin by complete or incomplete alkaline deacetylation, is the most attractive candidate due to its biochemical activity, biocompatibility, biodegradability and low toxicity [14], and has been widely used in pharmaceutical and nutritional formulations.”
BackgroundPreparation, characterization, and antioxidant properties of gallic acid-grafted-chitosans
Cho, Y.-S., Kim, S.-K., Ahn, C.-B., & Je, J.-Y. (2011) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.10.019 · Cited by 193
Shive, M., Stanish, W., McCormack, R., Forriol, F., Mohtadi, N., Pelet, S., Desnoyers, J., Méthot, S., Vehik, K., & Restrepo, A. (2015) · Cartilage · doi:10.1177/1947603514562064 · Cited by 191
About mechanism of chitosan cross-linking with glutaraldehyde
Kildeeva, N., Perminov, P. A., Vladimirov, L., Novikov, V. V., & Mikhailov, S. N. (2009) · Russian journal of bioorganic chemistry · doi:10.1134/s106816200903011x · Cited by 191
Usman, A., Zia, K., Zuber, M., Tabasum, S., Rehman, S., & Zia, F. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.02.004 · Cited by 187
Lee, S.-J., Heo, D., Moon, J., Ko, W.-K., Lee, J., Bae, M. S., Park, S., Kim, J. E., Lee, D. H., Kim, E.-C., et al. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.04.026 · Cited by 186
Utilization of carboxymethyl chitosan in cosmetics
Jimtaisong, A., & Saewan, N. (2014) · International Journal of Cosmetic Science · doi:10.1111/ics.12102 · Cited by 185
Water Soluble Polymer Flocculants: Synthesis, Characterization, and Performance Assessment
Vajihinejad, V., Gumfekar, S. P., Bazoubandi, B., Najafabadi, Z. R., & Soares, J. B. P. (2018) · Macromolecular Materials and Engineering · doi:10.1002/mame.201800526 · Cited by 223
The Role of Chitosan in Emulsion Formation and Stabilization
Klinkesorn, U. (2013) · doi:10.1080/87559129.2013.818013 · Cited by 172
“Therefore, chitosan is peculiar for its cationicity and the consequent capacity to form polyelectrolyte complexes with anionic groups.(16) An increase in the DDA and hence the number of NH2 groups results in the complexation capability of chitosan becoming stronger due to an increase of the apparent charge density.”
BackgroundMethodInfluentialChitosan-hydroxycinnamic acid conjugates: preparation, antioxidant and antimicrobial activity.
Lee, D., Woo, J.-Y., Ahn, C.-B., & Je, J.-Y. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2013.10.019 · Cited by 163
Pinto, R. J. B., Fernandes, S., Freire, C. S. R., Sadocco, P., Causio, J., Pascoal, C., & Trindade, T. (2012) · Carbohydrate Research · doi:10.1016/j.carres.2011.11.009 · Cited by 163
Engineering nanomaterials to overcome the mucosal barrier by modulating surface properties
Wu, L., Shan, W., Zhang, Z., & Huang, Y. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.10.001 · Cited by 206
Synthesis of chitosan-caffeic acid derivatives and evaluation of their antioxidant activities.
Aytekin, A., Morimura, S., & Kida, K. (2011) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2010.09.018 · Cited by 155
Polymeric micelles in mucosal drug delivery: challenges towards clinical translation
Sosnik, A., & Menaker Raskin, M. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.01.003 · Cited by 154
Crustacean Waste-Derived Chitosan: Antioxidant Properties and Future Perspective
Muthu, M., Gopal, J., Chun, S. C., Devadoss, A. J. P., Hasan, N., & Sivanesan, I. (2021) · Antioxidants · doi:10.3390/antiox10020228 · Cited by 194
Lin, M. M., Kim, D. K., Haj, A. J. E., & Dobson, J. (2008) · IEEE Transactions on NanoBioscience · doi:10.1109/tnb.2008.2011864 · Cited by 159
“) [18] Cost-effective chitosan, with its bioadhesive and biocompatible properties,”
BackgroundYan, H., Li, H., Yang, H., Li, A.-M., & Cheng, R.-S. (2013) · Chemical Engineering Journal · doi:10.1016/j.cej.2013.02.113 · Cited by 147
Advances in Functional Biopolymer-Based Nanocomposites for Active Food Packaging Applications
Basavegowda, N., & Baek, K.-H. (2021) · Polymers · doi:10.3390/polym13234198 · Cited by 230
“considered a potential polymer for food packaging, especially in the form of edible films and coatings [109].”
BackgroundWeißpflog, J., Vehlow, D., Müller, M., Kohn, B., Scheler, U., Boye, S., & Schwarz, S. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.01.010 · Cited by 145
Mercury(II) Removal with Modified Magnetic Chitosan Adsorbents
Kyzas, G., & Deliyanni, E. (2013) · Molecules · doi:10.3390/molecules18066193 · Cited by 140
“It is a hydrophilic, nontoxic, biodegradable, and biocompatible material with the ability to form complexes with metals [1–3].”
BackgroundChitosan: A Promising Marine Polysaccharide for Biomedical Research
Periayah, M. H., Halim, A., & Saad, A. (2016) · Pharmacognosy Reviews · doi:10.4103/0973-7847.176545 · Cited by 136
“[4,5] Chitosan is derived from the N ‑deacetylation form of chitin.”
Mayachiew, P., & Devahastin, S. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2009.05.027 · Cited by 129
Bruno, S. F., Ekorong, F. J. A. A., Karkal, S. S., Cathrine, M., & Kudre, T. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.12.004 · Cited by 128
Liu, B.-J., Wang, D.-F., Li, H.-Y., Xu, Y., & Zhang, L. (2011) · Desalination · doi:10.1016/j.desal.2011.01.034 · Cited by 126
Zamora-Mora, V., Fernández‐Gutiérrez, M., González‐Gómez, Á., Sanz, B., Román, J. S., Goya, G. F., Hernández, R., & Mijangos, C. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.09.084 · Cited by 130
Kyzas, G., Kostoglou, M., Lazaridis, N., Lambropoulou, D., & Bikiaris, D. (2013) · Chemical Engineering Journal · doi:10.1016/j.cej.2013.02.048 · Cited by 121
“In general, the amino groups of Cs are protonated at acidic pH values and consequently the material becomes positively charged [46,47].”
BackgroundOligodendrocyte-protection and remyelination post-spinal cord injuries: A review
Mekhail, M., Almazán, G., & Tabrizian, M. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.01.008 · Cited by 124
Chitosan as a Natural Copolymer with Unique Properties for the Development of Hydrogels
El-banna, F. S., Mahfouz, M., Leporatti, S., El-Kemary, M., & Hanafy, N. (2019) · Applied Sciences · doi:10.3390/app9112193 · Cited by 119
“It also can affect the polymers matrix if the degree of cross-linking is high, giving it an insoluble property in different types of solvents [47].”
BackgroundBiological Chitin-MOF Composites with Hierarchical Pore Systems for Air-Filtration Applications.
Wisser, D., Wisser, F., Raschke, S., Klein, N., Leistner, M., Grothe, J., Brunner, E., & Kaskel, S. (2015) · Angewandte Chemie · doi:10.1002/anie.201504572 · Cited by 115
Chen, R.-P., Zhang, Y.-L., Shen, L.-F., Wang, X., Chen, J.-Q., Ma, A.-J., & Jiang, W. (2015) · doi:10.1016/j.cej.2015.01.081 · Cited by 114
Khan, S., Khan, S. B., Kamal, T., Yasir, M., & Asiri, A. M. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.06.018 · Cited by 113
Physiochemical and optical properties of chitosan based graphene oxide bionanocomposite.
Kumar, S., & Koh, J. (2014) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2014.07.019 · Cited by 113
Fundamentals and Applications of Chitosan
Morin‐Crini, N., Lichtfouse, E. A., Torri, G., & Crini, G. (2019) · Sustainable agriculture reviews · doi:10.1007/978-3-030-16538-3_2 · Cited by 171
“Indeed, this biopolymer is the only natural cationic polymer in the nature (Muzzarelli and Muzzarelli 2005; Rinaudo 2006).”
BackgroundVino, A. B., Ramasamy, P., Shanmugam, V., & Shanmugam, A. (2012) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/s2221-1691(12)60184-1 · Cited by 112
“as additives in food and cosmetic products, as drug and gene delivery system or as chiral stationary phases for HPLC[10,14-18].”
BackgroundPolyurethane-Grafted Chitosan as New Biomaterials for Controlled Drug Delivery
Mahanta, A. K., Mittal, V., Singh, N., Dash, D., Malik, S., Kumar, M., & Maiti, P. (2015) · Macromolecules · doi:10.1021/acs.macromol.5b00030 · Cited by 110
Chitosan-Based Nanocomposite Polymeric Membranes for Water Purification—A Review
Spoială, A., Ilie, C.-I., Ficai, D., Ficai, A., & Andronescu, E. (2021) · Materials · doi:10.3390/ma14092091 · Cited by 138
“Chitosan presents very interesting polymeric forms, having unique structures and properties, and functionalities that target multiple applications from biomedicine, agricultural, and environmental protection [7,8].”
BackgroundMayachiew, P., Devahastin, S., Mackey, B. M., & Niranjan, K. (2009) · Food Research International · doi:10.1016/j.foodres.2009.09.006 · Cited by 101
In situ gelling dorzolamide loaded chitosan nanoparticles for the treatment of glaucoma.
Katiyar, S., Pandit, J., Mondal, R. S., Mishra, A., Chuttani, K., Aqil, M., Ali, A., & Sultana, Y. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.10.079 · Cited by 104
Chitosan oligosaccharide-arachidic acid-based nanoparticles for anti-cancer drug delivery.
Termsarasab, U., Cho, H.-J., Kim, D. H., Chong, S., Chung, S., Shim, C., Moon, H. T., & Kim, D.-D. (2013) · International journal of pharmaceutics · doi:10.1016/j.ijpharm.2012.11.018 · Cited by 104
3D printing of high-strength chitosan hydrogel scaffolds without any organic solvents
Zhou, L., Ramezani, H., Sun, M., Xie, M., Nie, J., Lv, S., Cai, J., Fu, J., & He, Y. (2020) · Biomaterials Science · doi:10.1039/d0bm00896f · Cited by 154
Solubility of lignin and chitin in ionic liquids and their biomedical applications
Singh, S. K. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.03.182 · Cited by 115
Chitosan-graphene oxide based aptasensor for the impedimetric detection of lysozyme.
Erdem, A., Ekşin, E., & Muti, M. (2014) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2013.11.037 · Cited by 101
A Process for the Preparation of Chitin and Chitosan from Prawn Shell Waste
Nessa, F., Masum, S., Asaduzzaman, M., Roy, S., Hossain, M., & Jahan, M. (2011) · doi:10.3329/bjsir.v45i4.7330 · Cited by 101
de Almeida, É. V. D., Frollini, E., Castellan, A., & Coma, V. (2010) · doi:10.1016/j.carbpol.2009.10.039 · Cited by 100
Dessı̀, M., Borzacchiello, A., Mohamed, T., Abdel-Fattah, W., & Ambrosio, L. (2013) · Journal of Biomedical Materials Research. Part A · doi:10.1002/jbm.a.34592 · Cited by 99
3D Printing of Silk Particle-Reinforced Chitosan Hydrogel Structures and Their Properties
Zhang, J., Allardyce, B. J., Rajkhowa, R., Zhao, Y. J., Dilley, R. J., Redmond, S. L., Wang, X., & Liu, X. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b00804 · Cited by 114
Chitosan/agarose hydrogels: cooperative properties and microfluidic preparation.
Zamora-Mora, V., Velasco, D., Hernández, R., Mijangos, C., & Kumacheva, E. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.04.087 · Cited by 98
Biomedical applications and colloidal properties of amphiphilically modified chitosan hybrids
Larsson, M., Huang, W.-C., Hsiao, M.-H., Wang, Y.-J., Nydén, M., Chiou, S., & Liu, D.-M. (2013) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2013.06.009 · Cited by 100
“Chitosan is a polysaccharide that has been extensively investigated for biomedical applications, with many reports on modified chitosan exhibiting new functionalities [7–15].”
BackgroundMicro/Nanostructured Polymeric Systems for Biomedical and Pharmaceutical Applications
Chiellini, E., Piras, A. M., Errico, C., & Chiellini, E. (2008) · Nanomedicine · doi:10.2217/17435889.3.3.367 · Cited by 94
“In addition, it has good adhesion properties [58], coagulation ability and immunostimulating activity [59].”
BackgroundFundamentals of chitosan for biomedical applications
Vunain, E., Mishra, A. K., & Mamba, B. B. (2016) · Elsevier eBooks · doi:10.1016/b978-0-08-100230-8.00001-7 · Cited by 108
An Overview of Chitosan Nanofibers and their Applications in the Drug Delivery Process
AL-Jbour, N. D., Beg, M. D., Gimbun, J., & Alam, A. K. M. M. (2019) · Current Drug Delivery · doi:10.2174/1567201816666190123121425 · Cited by 92
Blood coagulation evaluation of N-alkylated chitosan.
Chen, Z.-H., Yao, X., Liu, L., Guan, J., Liu, M., Li, Z.-H., Yang, J., Huang, S., Wu, J.-M., Tian, F., et al. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.05.085 · Cited by 91
Antioxidant and Moisturizing Properties of Carboxymethyl Chitosan with Different Molecular Weights
Chaiwong, N., Leelapornpisid, P., Jantanasakulwong, K., Rachtanapun, P., Seesuriyachan, P., Sakdatorn, V., Leksawasdi, N., & Phimolsiripol, Y. (2020) · Polymers · doi:10.3390/polym12071445 · Cited by 89
Li, C.-W., Wang, Q., Li, J., Hu, M., Shi, S.-J., Li, Z.-W., Wu, G.-L., Cui, H.-H., Li, Y.-Y., Zhang, Q., et al. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s91975 · Cited by 89
“16,22,28 To investigate collagen fiber production, immunofluorescent staining was used to stain collagen I (green) and collagen III (red) at 3, 7, and 18 days after grafting (Figure 4B–”
Suryawanshi, N., Eswari, S., & Ayothiraman, S. (2019) · International Journal of Environmental Science and Technology · doi:10.1007/s13762-018-02204-3 · Cited by 101
“2014; Sethulekshmi 2014), edible antimicrobial coating and packaging (Muzzarelli and Muzzarelli 2005; Wang et al. 2018), dietary fibers (Xia et al.”
BackgroundAsim, N., Badiei, M., Alghoul, M. A., Mohammad, M., Fudholi, A., Akhtaruzzaman, M., Amin, N., & Sopian, K. (2019) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.9b02661 · Cited by 109
Metadata
- Authors
- Muzzarelli, R. A. A., & Muzzarelli, C.
- Affiliations
- Marche Polytechnic University (IT)
- Venue
- Advances in Polymer Science
- Publisher
- Springer-Verlag
- Published
- 2005-11-16
- Pages
- 151-209
- OpenAlex
- W2486270894
- Cited by
- 555
- References
- 290
- Citations by year
- 2026: 5 · 2025: 17 · 2024: 22 · 2023: 22 · 2022: 18 · 2021: 28 · 2020: 33 · 2019: 39 · 2018: 26 · 2017: 39 · 2016: 45 · 2015: 33 · 2014: 35 · 2013: 42 · 2012: 38
- FWCI
- 53.63
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Springer eBooks (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanocomposite Films for Food Packaging
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Keywords
- chitosan, chitin, drug delivery, drug carriers, biocompatibility, biodegradability, wound healing, coagulation, immunostimulation, chitin nanoparticles, nanofibrils, bandages, nutraceuticals, cosmetics
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