Characterization of the in vivo release of dopamine as recorded by different types of intracerebral microdialysis probes

Santiago, M.; Westerink, B.H.C.

doi:10.1007/bf00169457

Cited by 160Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeurological disorders and treatments

Characterization of the in vivo release of dopamine as recorded by different types of intracerebral microdialysis probes

Santiago, M., Westerink, B.H.C.·1990·Naunyn-Schmiedeberg's Archives of Pharmacology

DOI 10.1007/bf00169457

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Abstract

Microdialysis of dopamine was performed in the striatum with four different microdialysis cannulas: a trans-cerebral probe, a U-shaped probe, a I-shaped probe and a commercially available I-shaped probe (Carnegie). The commercial cannula was studied with as well as without a guide cannula. The effect of infusion of tetrodotoxin (TTX) or calcium free-Ringer solution on the dialysate content of dopamine released was determined 2 h after implantation (day 1) as well as 24 h after implantation (day 2). Two hours after implantation, all cannulas displayed a certain amount of TTX-independent overflow of dopamine. The best results were obtained with the I-shaped cannula: already 2 h after implantation of the probe, about 85% of the release of dopamine was TTX-dependent. In case of the trans-cerebral cannula and the Carnegie cannula (implanted without guide in anesthetized rats), 70-75% of the output of dopamine was TTX-dependent. When the Carnegie cannula was implanted with a guide cannula, only 45% of the dopamine output was TTX-dependent. The responses to calcium-free perfusion were much more variable. Dopamine output in I-shaped and the U-shaped probes was virtually insensitive to calcium-free perfusion in acute experiments. Twenty-four hours after implantation of the probes, the calcium- and TTX-dependency was much more pronounced. All types of cannulas studied now sampled dopamine that was completely TTX-dependent. Calcium-free perfusion caused a reproducible disappearance of dopamine from the dialysates to 30% of controls, in all cannulas studied. When the removable Carnegie cannula was re-implanted 24 h after its first implantation, 91% of the dopamine overflow was TTX-sensitive. These results confirm earlier conclusions that microdialysis experiments should be carried out at least 24 h after implantation of the probe.

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Solutions for balancing power delivery and data transmission can result in compromises such as trade-offs between implant size and power capacity or between energy efficiency and data rate.
“However, these solutions can sometimes result in compromises, such as trade-offs between the size of the implant and its power capacity or between the energy efficiency and the data rate (Santiago and Westerink, 1990; Deboer and Abercrombie, 1996; Jaquins-Gerstl and Michael, 2009; Kozai et al., 2012).”
From Comparative analysis of energy transfer mechanisms for neural implants (2024) · cites this paper as Santiago and Westerink, 1990
The inter-relationship between power transfer and data communication in neural implants introduces additional difficulty.
“Furthermore, the inter-relationship between power transfer and data communication in these implants introduces additional layers of difficulty.”
From Comparative analysis of energy transfer mechanisms for neural implants (2024) · cites this paper as Santiago and Westerink, 1990
Smaller devices, like carbon fiber electrodes, show reduced tissue damage and inflammatory responses while maintaining better signal quality.
“Conversely, smaller devices, like carbon fiber electrodes, show reduced tissue damage and inflammatory responses while maintaining better signal quality (Santiago and Westerink, 1990; Deboer and Abercrombie, 1996).”
From Comparative analysis of energy transfer mechanisms for neural implants (2024) · cites this paper as Santiago and Westerink, 1990

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Authors: Santiago, M., & Westerink, B. H. C.
Affiliations: University of Groningen (NL)
ORCID: Santiago, M.
Venue: Naunyn-Schmiedeberg's Archives of Pharmacology
Publisher: Springer Science and Business Media LLC
Published: 1990-10
Volume: 342
Issue: 4
Pages: 407-14
ISSN: 0028-1298 (ISSN-L)
1432-1912
DOI: 10.1007/bf00169457
OpenAlex: W2126184291
Cited by: 159
References: 11
Citations by year: 2025: 1 · 2024: 1 · 2022: 2 · 2020: 4 · 2019: 2 · 2017: 3 · 2016: 2 · 2015: 7 · 2014: 6 · 2013: 1 · 2012: 1
FWCI: 5.17
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Naunyn-Schmiedeberg s Archives of Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords: dopamine release, microdialysis probe, striatum, tetrodotoxin, calcium-free perfusion, dopamine overflow, in vivo release
MeSH terms: Animals, Brain Chemistry, Calcium, Catheterization, Chromatography, High Pressure Liquid, Corpus Striatum, Dialysis, Dopamine, Homovanillic Acid, Hydroxyindoleacetic Acid, Tetrodotoxin, 3,4-Dihydroxyphenylacetic Acid, Rats

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Characterization of the in vivo release of dopamine as recorded by different types of intracerebral microdialysis probes

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