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Cited by 116Sleep and related disordersTreatment of Major DepressionSleep and Wakefulness Research

The DOI matches its Crossref record.

Effects of trazodone on the sleep of depressed subjects—a polygraphic study

Mouret, J., Lemoine, P., Minuit, M.P., Benkelfat, C., Renardet, M.·1988·Psychopharmacology
DOI 10.1007/bf00172629
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Abstract

The effects of 400-600 mg trazodone on the sleep patterns of ten depressed in-patients treated for 5 weeks were studied during the initial (days 1-3) and terminal (days 26-28) treatment periods. The sleep parameters were compared to those obtained from three sleep recordings performed just prior to the initiation of the treatment and after 2 adaptation nights at the end of a 2-week drug-free period. At the same time, the clinical evolution of patients was evaluated weekly using MADRS and Hamilton-Anxiety scales for anxiety-depression symptomatology and Spiegel and Norris sleep scales. Weekly blood samples were collected to measure plasma levels of trazodone and, at the end of the study, the elimination half-life at steady state was calculated by repeated measurements of plasma levels. Clinical improvement, as assessed by a reduction of more than 60% in MADRS scale scores, was accompanied by evidence of the definitely beneficial effects of trazodone on the disturbed sleep of these depressed patients. From the beginning of treatment, there was a hypnotic-like effect (increase in total duration of sleep and stage II, decrease in sleep latency and intrasleep awakenings). In addition, records at the end of the study showed an increase in delta sleep and an increase in REM latency, an effect classically associated with an antidepressant action. These particularly valuable effects of trazodone on sleep would suggest that this drug should especially be given in cases of depression wi…

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  • Trazodone has also shown to suppress REM sleep in some studies, which seems at odds with the relative lack of serotonin reuptake antagonism and the inhibition of 5-HT1A.

    “However, trazodone has also shown to suppress REM sleep in some studies (Mouret et al., 1988), which seems at odds with the relative lack of serotonin reuptake antagonism and the inhibition of 5-HT1A (Wilson and Argyropoulos, 2005).”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Mouret et al., 1988

  • Mouret et al. noted increased total sleep time, decreased sleep latency, fewer awakenings, and an increase in delta sleep with increased REM latency associated with trazodone treatment in depressed inpatients.

    “Mouret et al. [1988] noted increased total sleep time, decreased sleep latency, fewer awakenings, and an increase in delta sleep with increased REM latency associated with trazodone treatment in depressed inpatients.”

    From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as Mouret et al., 1988

  • The most consistently reported effect of trazodone on sleep in depressed patients was REM suppression, expressed as either decreased REM time or REM percentage, or increased REM latency.

    “The most consistently reported effect of trazodone on sleep in depressed patients was REM suppression, expressed as either decreased REM time or REM percentage, or increased REM latency [Mouret et al., 1988;Ware et al., 1994;van Bemmel and Havermans, 1992;Scharf and Sachais, 1990].”

    From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as Mouret et al., 1988

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Metadata

Authors
Mouret, J., Lemoine, P., Minuit, M. P., Benkelfat, C., & Renardet, M.
Affiliations
Centre Hospitalier Le Vinatier (FR)
ORCID
Lemoine, P.
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
1988
Volume
95
Issue
1
Pages
S37-43
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/bf00172629
OpenAlex
W1984708522
Cited by
116
References
0
Citations by year
2026: 1 · 2025: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 5 · 2015: 3 · 2014: 2 · 2012: 3
FWCI
1.49
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
trazodone, depression, sleep disorders, insomnia, hypnotic effects, REM latency, delta sleep, sleep latency, antidepressant effects, plasma drug concentration, elimination half-life, hospitalized patients
MeSH terms
Adult, Depressive Disorder, Electroencephalography, Female, Half-Life, Humans, Male, Middle Aged, Sleep, Sleep Stages, Sleep, REM, Trazodone

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