Cited by 481Sleep and related disordersSleep and Wakefulness ResearchAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Comorbidity of insomnia and depression

Staner, Luc·2010·Sleep Medicine Reviews

Abstract

During the last decade, several studies have shown that insomnia, rather than a symptom of depression, could be a medical condition on its own, showing high comorbidity with depression. Epidemiological research indicates that insomnia could lead to depression and/or that common causalities underlie the two disorders. Neurobiological and sleep EEG studies suggest that a heightened level of arousal may play a common role in both conditions and that signs of REM sleep disinhibition may appear in individuals prone to depression. The effects of antidepressant drugs on non-REM and REM sleep are discussed in relation to their use in insomnia comorbid with depression. Empirical treatment approaches are behavioral management of sleep combined with prescription of a sedative antidepressant alone, co-prescription of two antidepressants, or of an antidepressant with a hypnotic drug.

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Crossref · 10.1016/j.smrv.2009.09.003

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Authors
Staner, L.
Affiliations
Centre hospitalier de Rouffach (FR)
Corresponding author
Staner, Luc
Venue
Sleep Medicine Reviews
Publisher
Elsevier BV
Published
2010-02
Volume
14
Issue
1
Pages
35-46
ISSN
1087-0792 (ISSN-L)
OpenAlex
W2046148869
Cited by
481
References
235
Citations by year
2026: 19 · 2025: 45 · 2024: 35 · 2023: 41 · 2022: 33 · 2021: 34 · 2020: 29 · 2019: 35 · 2018: 24 · 2017: 33 · 2016: 32 · 2015: 33 · 2014: 15 · 2013: 26 · 2012: 25
FWCI
2.24
Type
journal article
Language
en
Open access
closed
Locations
  • Sleep Medicine Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
insomnia, depression, comorbidities, sleep arousal, antidepressants, hypnotics, sleep EEG, neurobiology of depression
MeSH terms
Behavior Therapy, Combined Modality Therapy, Depressive Disorder, Electroencephalography, Humans, Hypnotics and Sedatives, Sleep Initiation and Maintenance Disorders, Sleep, REM, Comorbidity

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