Comorbidity of insomnia and depression
Abstract
During the last decade, several studies have shown that insomnia, rather than a symptom of depression, could be a medical condition on its own, showing high comorbidity with depression. Epidemiological research indicates that insomnia could lead to depression and/or that common causalities underlie the two disorders. Neurobiological and sleep EEG studies suggest that a heightened level of arousal may play a common role in both conditions and that signs of REM sleep disinhibition may appear in individuals prone to depression. The effects of antidepressant drugs on non-REM and REM sleep are discussed in relation to their use in insomnia comorbid with depression. Empirical treatment approaches are behavioral management of sleep combined with prescription of a sedative antidepressant alone, co-prescription of two antidepressants, or of an antidepressant with a hypnotic drug.
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The strong association of depressive and insomnia symptoms is consistent with evidence supporting their high level of comorbidity.
“The strong association of depressive and insomnia symptoms is consistent with evidence supporting their high level of comorbidity [35, 62–65].”
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“Chronic insomnia has been associated with a number of negative health outcomes, including obesity and metabolic dysregulation [3,4], hypertension and increased risk of myocardial infarction [5,6], increased susceptibility to infections [7], and depression [8].”
BackgroundInsomnia and Daytime Sleepiness Are Risk Factors for Depressive Symptoms in the Elderly
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Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents
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Insomnia and depression: clinical associations and possible mechanistic links
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Sleep and dreaming are for important matters
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“Psychological conditions such as anxiety, depression, and stress may also be present in patients with insomnia (Staner, 2010).”
BackgroundTse, K. Y. K., Maurer, L. F., Espie, C. A., & Kyle, S. D. (2024) · Journal of Sleep Research · doi:10.1111/jsr.14180 · Cited by 12 · see citing works
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“The strong association of depressive and insomnia symptoms is consistent with evidence supporting their high level of comorbidity [35, 62–65].”
BackgroundResult
- Authors
- Staner, L.
- Affiliations
- Centre hospitalier de Rouffach (FR)
- Corresponding author
- Staner, Luc
- Venue
- Sleep Medicine Reviews
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 14
- Issue
- 1
- Pages
- 35-46
- ISSN
- 1087-0792 (ISSN-L)
- OpenAlex
- W2046148869
- Cited by
- 481
- References
- 235
- Citations by year
- 2026: 19 · 2025: 45 · 2024: 35 · 2023: 41 · 2022: 33 · 2021: 34 · 2020: 29 · 2019: 35 · 2018: 24 · 2017: 33 · 2016: 32 · 2015: 33 · 2014: 15 · 2013: 26 · 2012: 25
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sleep Medicine Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- insomnia, depression, comorbidities, sleep arousal, antidepressants, hypnotics, sleep EEG, neurobiology of depression
- MeSH terms
- Behavior Therapy, Combined Modality Therapy, Depressive Disorder, Electroencephalography, Humans, Hypnotics and Sedatives, Sleep Initiation and Maintenance Disorders, Sleep, REM, Comorbidity
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