The projections of the retrorubral field A8 to the hippocampal formation in the rat
Abstract
The dopaminergic neurons in the midbrain of the rat are located in three groups: the ventral tegmental area (VTA-A10), substantia nigra (SN-A9), and retrorubral field (RRF-A8). We have recently examined the organization of the projections from the VTA and the SN to the hippocampal formation (HF) in the rat. In the present study we characterize the projections of the RRF to the HF by using anterograde tracing, retrograde tracers, and tyrosine hydroxylase (TH) immunohistochemistry. Following iontophoretical injections of Phaseolous vulgaris leucoagglutinin (PHA-L) into the RRF, anterograde labeling was observed primarily in the ipsilateral subiculum and adjacent CA1 cell field. Sparse labeling was also observed in the CA3 cell field and dentate gyrus. The distribution of RRF neurons projecting to the HF was examined by injecting retrograde fluorescent tracers (fluorogold, fast blue, and nuclear yellow) into several hippocampal areas. The retrograde tracer findings indicate that the medial aspects of the RRF project to the subiculum and adjacent CA1 cell field of both the septal and temporal HF. In order to evaluate the percentage of dopaminergic cells of the RRF projecting to the HF, the retrograde neuronal tracer fluorogold was used in combination with TH immunohistochemistry. The quantitative evaluation of retrograde labeled and TH-immunoreactive (IR) cells showed that RRF projections to the HF are partially (10-18%) dopaminergic. The findings suggest that the general pattern of distribution and organization of the RRF-A8 projections to the HF is similar to that observed in our previous studies examining hippocampal afferents from the VTA and SN. The data also suggest a crude topographical organization of RRF afferents to the HF and a more prominent input to the temporal than to the septal HF.
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Dopaminergic projections originating primarily from the midbrain project directly to the hippocampus.
“Earlier evidence indicated that dopaminergic projections originating primarily from the midbrain (including the VTA, substantia nigra, and retrorubral field) project directly to the hippocampus (Gasbarri et al., 1994a; Gasbarri et al., 1996; Gasbarri et al., 1994b).”
From Dopamine regulates aversive contextual learning and associated in vivo synaptic plasticity in the Hippocampus (2016) · cites this paper as Gasbarri et al., 1996
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The dopaminergic mesencephalic projections to the hippocampal formation in the rat
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“Earlier evidence indicated that dopaminergic projections originating primarily from the midbrain (including the VTA, substantia nigra, and retrorubral field) project directly to the hippocampus (Gasbarri et al., 1994a, 1994b, 1996).”
BackgroundDopamine selectively potentiates hippocampal mossy fiber to CA3 synaptic transmission
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“Other studies, however, also indicate a sparse direct dopaminergic projection from midbrain DA neurons to the CA1 region of the hippocampus (Gasbarri et al., 1994, 1996; McNamara et al., 2014; Rosen et al., 2015; Broussard et al., 2016).”
Background
- Authors
- Gasbarri, A., Packard, M., Sulli, A., Pacitti, C., Innocenzi, R., & Perciavalle, V.
- Affiliations
- University of L'Aquila (IT)
- University of Catania (IT)
- Corresponding author
- Gasbarri, Antonella
- ORCID
- Gasbarri, Antonella
- Venue
- Experimental Brain Research
- Published
- 1996-11
- Volume
- 112
- Issue
- 2
- Pages
- 244-52
- ISSN
- 0014-4819 (ISSN-L)
- 1432-1106
- OpenAlex
- W2047804928
- Cited by
- 51
- References
- 31
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 1 · 2021: 1 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 2
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Experimental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- retrorubral field, hippocampal formation, dopaminergic pathways, subiculum, CA1, CA3, dentate gyrus, midbrain dopaminergic neurons, tyrosine hydroxylase, anterograde tracing, retrograde tracing, topographic organization, rats
- MeSH terms
- Benzenesulfonamides, Amidines, Animals, Benzimidazoles, Brain Mapping, Fluorescent Dyes, Hippocampus, Immunohistochemistry, Male, Synaptic Transmission, Phytohemagglutinins, Red Nucleus, Stilbamidines, Tyrosine 3-Monooxygenase, Rats, Sprague-Dawley, Rats
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