Dopamine selectively potentiates hippocampal mossy fiber to CA3 synaptic transmission
Abstract
Dopamine has been implicated in various brain functions and the pathology of neurological diseases. In the hippocampus, dopamine has been shown to induce acute depression of synaptic transmission in the CA1 region, but it remains largely unknown how it works in the CA3 region. We here report that dopamine induces acute synaptic potentiation at the synapse formed by mossy fibers (MFs) on mouse hippocampal CA3 pyramidal cells, but not at converging associational/commissural synapses. Dopamine potentiated both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-d-aspartate (NMDA) components of MF synaptic responses similarly in respect of the magnitude and time course. The dopamine-induced potentiation was intact in the presence of picrotoxin, required activation of D(1)-like receptors and was apparently occluded by an activator of adenylate cyclase. The potentiation was accompanied by a decrease in magnitude of synaptic facilitation, suggesting the presynaptic site for the expression of the potentiation. The present study is the first demonstration of acute potentiation of hippocampal excitatory synaptic transmission by dopamine, which is most probably mediated by presynaptic D(1)-like receptor-cAMP cascades.
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Several neuromodulators, such as acetylcholine, dopamine, and noradrenaline, have been reported to affect mossy fiber synaptic transmission.
“Several neuromodulators, such as acetylcholine [97], dopamine [98], and noradrenaline [54] have been reported to affect mossy fiber synaptic transmission.”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [98]
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(2010) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195342796.002.0005
(2010) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195342796.002.0009
Grosmark, A., Milstein, A. D., Losonczy, A., & Soltész, I. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780190065324.003.0007
Asada-Utsugi, M., Uemura, K., Kubota, M., Noda, Y., Tashiro, Y., Uemura, T. M., Yamakado, H., Urushitani, M., Takahashi, R., Hattori, S., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13642211
Self-citationHippocampal-striatal interaction in Parkinson’s disease with mild cognitive impairment
Xu, J., Tan, S., Zhang, X., Zhang, M., & Xu, X. (2026) · Clinical Parkinsonism & Related Disorders · doi:10.1016/j.prdoa.2026.100443
Developmental changes in activity-dependent plasticity of maturation-related neuronal phenotypes
Kobayashi, K., & Imbe, H. (2026) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2026.1926357
Self-citation
- Authors
- Kobayashi, K., & Suzuki, H.
- Affiliations
- Nippon Medical School (JP)
- Corresponding author
- Kobayashi, Katsunori
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 52
- Issue
- 2
- Pages
- 552-561
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2013179530
- Cited by
- 63
- References
- 54
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 4 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Human Frontier Science Program
- Ministry of Education, Culture, Sports, Science and Technology
- Uehara Memorial Foundation (16590208)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dopamine, mossy fiber synapses, hippocampal CA3, synaptic potentiation, D1-like receptors, cAMP signaling, presynaptic facilitation, AMPA receptors, NMDA receptor, excitatory synaptic transmission, picrotoxin
- MeSH terms
- Adenine, Animals, Dopamine, Dose-Response Relationship, Drug, Electric Stimulation, Enzyme Inhibitors, Hippocampus, Male, Synaptic Transmission, Pyramidal Cells, Patch-Clamp Techniques, Dopamine Agonists, Excitatory Amino Acid Antagonists, 6-Cyano-7-nitroquinoxaline-2,3-dione, Mossy Fibers, Hippocampal, Excitatory Postsynaptic Potentials, Mice, In Vitro Techniques
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