Telomeric structure in cells with chromosome end associations
Abstract
End-to-end associations of metaphase chromosomes have been observed in a variety of human tumors, ageing cells, and several chromosome instability syndromes. Since telomeres of tumor cells and ageing tissues are often reduced in length, it has been suggested that chromosome end associations may be due to loss of telomeric repeats. We report the molecular structure of telomeres of two human tumor cell lines with frequent end-to-end associations of metaphase chromosomes. These telomeres were shown to be severely reduced compared with most other human cells with functional telomeres. However, we also describe two cell lines with severely shortened telomeres that are not detectably compromised in their function. We suggest that telomeric length is not the only determinant of the fusigenic behavior of human telomeres in tumor cells.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
HeLall has shorter telomeres ranging from 3 to 6.5 kb (6 kb median).
“HeLal.2.11 has telomeres of approximately 15 to 40 kb (21), whereas HeLall has shorter telomeres ranging from 3 to 6.5 kb (6 kb median) (39).”
From Control of Human Telomere Length by TRF1 and TRF2 (2000) · cites this paper as [39]
Cites
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works
Structure and function of telomeres
Blackburn, E. H. (1991) · Nature · doi:10.1038/350569a0 · Cited by 3,596 · see citing works
Moyzis, R. K., Buckingham, J. M., Cram, L. S., Dani, M. A. C., Deaven, L. L., Jones, M. D., Meyne, J., Ratliff, R. L., & Wu, J. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6622 · Cited by 2,326 · see citing works
Sen, D., & Gilbert, W. (1988) · Nature · doi:10.1038/334364a0 · Cited by 1,668 · see citing works
Telomere reduction in human colorectal carcinoma and with ageing
Hastie, N. D., Dempster, M., Dunlop, M. G., Thompson, A. M., Green, D. K., & Allshire, R. C. (1990) · Nature · doi:10.1038/346866a0 · Cited by 1,650 · see citing works
THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS
McClintock, B. (1941) · Genetics · doi:10.1093/genetics/26.2.234 · Cited by 1,610 · see citing works
Morin, G. B. (1989) · Cell · doi:10.1016/0092-8674(89)90035-4 · Cited by 1,495 · see citing works
Monovalent cation-induced structure of telomeric DNA: The G-quartet model
Williamson, J. R., Raghuraman, M. K., & Cech, T. R. (1989) · Cell · doi:10.1016/0092-8674(89)90610-7 · Cited by 1,228 · see citing works
Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops
Sundquist, W., & Klug, A. (1989) · Nature · doi:10.1038/342825a0 · Cited by 868 · see citing works
Structure and variability of human chromosome ends.
de Lange, T., Shiue, L., Myers, R. M., Cox, D. R., Naylor, S. L., Killery, A. M., & Varmus, H. E. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.2.518 · Cited by 848 · see citing works
Conservation of the human telomere sequence (TTAGGG)n among vertebrates.
Meyne, J., Ratliff, R. L., & Moyzis, R. K. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.18.7049 · Cited by 838 · see citing works
THE MOLECULAR STRUCTURE OF CENTROMERES AND TELOMERES
Blackburn, E. H., & Szostak, J. W. (1984) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.53.070184.001115 · Cited by 697 · see citing works
STRUCTURE AND FUNCTION OF TELOMERES
Zakian, V. A. (1989) · Annual Review of Genetics · doi:10.1146/annurev.ge.23.120189.003051 · Cited by 603 · see citing works
Crystal structure of four-stranded Oxytricha telomeric DNA
Kang, C., Zhang, X., Ratliff, R. L., Moyzis, R. K., & Rich, A. (1992) · Nature · doi:10.1038/356126a0 · Cited by 555 · see citing works
Quadruplex structure of Oxytricha telomeric DNA oligonucleotides
Smith, F. W., & Feigon, J. F. (1992) · Nature · doi:10.1038/356164a0 · Cited by 523 · see citing works
Klobutcher, L. A., Swanton, M. T., Donini, P., & Prescott, D. M. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.5.3015 · Cited by 472 · see citing works
Three-dimensional architecture of a polytene nucleus
Agard, D. A., & Sedat, J. W. (1983) · Nature · doi:10.1038/302676a0 · Cited by 443 · see citing works
Human telomeres contain at least three types of G–rich repeat distributed non-randomly
Allshire, R. C., Dempster, M., & Hastie, N. D. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.12.4611 · Cited by 372 · see citing works
Structure and polymorphism of human telomere-associated DNA
Brown, W. R., MacKinnon, P. J., Villasanté, A., Spurr, N. K., Buckle, V. J., & Dobson, M. J. (1990) · Cell · doi:10.1016/0092-8674(90)90293-n · Cited by 371 · see citing works
Human telomeres are attached to the nuclear matrix.
de Lange, T. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05104.x · Cited by 333 · see citing works
Gottschling, D. E., & Zakian, V. A. (1986) · Cell · doi:10.1016/0092-8674(86)90442-3 · Cited by 297 · see citing works
An Overhanging 3′ Terminus Is a Conserved Feature of Telomeres
Henderson, E. R., & Blackburn, E. H. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.1.345 · Cited by 290 · see citing works
Cremer, T. J., Cremer, C. G., Baumann, H., Luedtke, E. K., Sperling, K., Teuber, V., & Zorn, C. (1982) · Human Genetics · doi:10.1007/bf00281263 · Cited by 288 · see citing works
Structure and Variability of Human Chromosome Ends
de Lange, T., Shiue, L., Myers, R., et al. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.2.518-527.1990 · Cited by 257 · see citing works
Human telomeres: fusion and interstitial sites
Hastie, N. D., & Allshire, R. C. (1989) · Trends in Genetics · doi:10.1016/0168-9525(89)90137-6 · Cited by 243 · see citing works
Variability at the Telomeres of the Human X/Y Pseudoautosomal Region
Cooke, H. J., & Smith, B. A. (1986) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1986.051.01.026 · Cited by 233 · see citing works
Functional reintroduction of human telomeres into mammalian cells.
Farr, C. J., Fantes, J. A., Goodfellow, P. N., & Cooke, H. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7006 · Cited by 185 · see citing works
Telomeric repeat from T. thermophila cross hybridizes with human telomeres
Allshire, R. C., Gosden, J. R., Cross, S. H., Cranston, G., Rout, D., Sugawara, N., Szostak, J. W., Fantes, P. A., & Hastie, N. D. (1988) · Nature · doi:10.1038/332656a0 · Cited by 183 · see citing works
Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos.
Pa, B. (1976) · PubMed · Cited by 168 · see citing works
Gottschling, D. E., & Cech, T. R. (1984) · Cell · doi:10.1016/0092-8674(84)90505-1 · Cited by 138 · see citing works
Rings, dicentrics, and telomeric association in histiocytomas
Mandahl, N., Heim, S., Arheden, K., Rydholm, A., Willén, H., & Mitelman, F. (1988) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(88)90089-1 · Cited by 116 · see citing works
Price, C. M. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.7.3421 · Cited by 107 · see citing works
Telomeric association of chromosomes in B-cell lymphoid leukemia
Fitzgerald, P. H., & Morris, C. M. (1984) · Human Genetics · doi:10.1007/bf00291396 · Cited by 105 · see citing works
Taylor, A. M. R., Oxford, J. M., & Metcalfe, J. A. (1981) · International Journal of Cancer · doi:10.1002/ijc.2910270309 · Cited by 103 · see citing works
The structure of a subterminal repeated sequence present on many human chromosomes
Cross, S. H., Lindsey, J. C., Fantes, J. A., McKay, S., McGill, N. I., & Cooke, H. J. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.22.6649 · Cited by 99 · see citing works
An Overhanging 3′ Terminus Is a Conserved Feature of Telomeres
Henderson, E. R., & Blackburn, E. H. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.1.345-348.1989 · Cited by 99 · see citing works
Chung, H. M., Shea, C., Fields, S. Z., Rn, T., der Ploeg, L. H. T. V., & Tse, D. B. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07443.x · Cited by 95 · see citing works
Higher order DNA structure in macronuclear chromatin of the hypotrichous ciliate Oxytricha nova.
Lipps, H. J., Gruissem, W., & Prescott, D. M. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.8.2495 · Cited by 93 · see citing works
Chromosomally Abnormal Clones and Nonrandom Telomeric Translocations in Cardiac Myxomas
Dewald, G. W., Dahl, R. J., Spurbeck, J. L., Carney, J. A., & Gordon, H. (1987) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62293-9 · Cited by 89 · see citing works
Rawlins, D. J., Highett, M. I., & Shaw, P. (1991) · Chromosoma · doi:10.1007/bf00364552 · Cited by 87 · see citing works
The terminal organization of macronuclear DNA INOxytricha fallax
Pluta, A. F., Kaine, B. P., & Spear, B. B. (1982) · Nucleic Acids Research · doi:10.1093/nar/10.24.8145 · Cited by 86 · see citing works
Yerganian, G., Shein, H. M., & Enders, J. F. (1962) · Cytogenetic and Genome Research · doi:10.1159/000129742 · Cited by 67 · see citing works
Telomeric association in two human renal tumors
Kovács, G., Müller-Brechlin, R., & Szűcs, S. (1987) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(87)90225-1 · Cited by 60 · see citing works
Telomeric association in a malignant fibrous histiocytoma
Mandahl, N., Heim, S., Kristoffersson, U., Mitelman, F., R��ser, B., Rydholm, A., & Will�n, H. (1985) · Human Genetics · doi:10.1007/bf00388457 · Cited by 60 · see citing works
Telomeric association: another characteristic of cancer chromosomes?
Pathak, S., Wang, Z., Dhaliwal, M. K., & Sacks, P. C. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000132555 · Cited by 59 · see citing works
Assembly and self-association of Oxytricha telomeric nucleoprotein complexes
Raghuraman, M. K., & Cech, T. R. (1989) · Cell · doi:10.1016/0092-8674(89)90018-4 · Cited by 56 · see citing works
van Dekken, H., Pinkel, D., Mullikin, J. C., Trask, B. J., van den Engh, G., & Gray, J. W. (1989) · Journal of Cell Science · doi:10.1242/jcs.94.2.299 · Cited by 51 · see citing works
Cytogenetic Analyses on Giant-Cell Tumors of Bone
Schwartz, H. S., Jenkins, R. B., Dahl, R. J., & DEWALD, G. W. (1989) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198903000-00033 · Cited by 45 · see citing works
Telomeric fusion in pre-T-cell acute lymphoblastic leukemia
Morgan, R., Jarzabek, V., Jaffe, J. P., Hecht, B. K., Hecht, F., & Sandberg, A. A. (1986) · Human Genetics · doi:10.1007/bf00401240 · Cited by 43 · see citing works
Self-citationHuman somatic chromosome chains and rings
Dutrillaux, B., CROQUETTE, M. F., Viégas-Pèquignot, E., Aurias, A., Coget, J., Couturier, J., & LEJEUNE, J. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000130841 · Cited by 34 · see citing works
Price, C. M. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.7.3421-3431.1990 · Cited by 33 · see citing works
Aledo, R., Aurias, A., Avril, M., & Dutrillaux, B. (1989) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(89)90150-7 · Cited by 30 · see citing works
Murray, A. W. (1990) · Nature · doi:10.1038/346797a0 · Cited by 28 · see citing works
Telomeric associations in a lymphoblastoid cell line from a patient with B-cell follicular lymphoma
Saltman, D. L., Ross, F. M., Fantes, J. A., Allshire, R. C., Turner, G. E., & Evans, H. J. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000132766 · Cited by 19 · see citing works
Self-citationTelomeric associations involving Yq12 in a lymphoblastoid cell line
Abruzzo, M. A., Miller, J. A., & Singer, V. L. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000133072 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
TRF2 Protects Human Telomeres from End-to-End Fusions
van Steensel, B., Smogorzewska, A., & de Lange, T. (1998) · Cell · doi:10.1016/s0092-8674(00)80932-0 · Cited by 1,709 · see citing works
Essential role of mouse telomerase in highly proliferative organs
Lee, H.-W., Blasco, M. A., Gottlieb, G. J., Horner, J. W., Greider, C. W., & DePinho, R. A. (1998) · Nature · doi:10.1038/33345 · Cited by 1,270 · see citing works
Control of Human Telomere Length by TRF1 and TRF2
Smogorzewska, A., van Steensel, B., Bianchi, A., Oelmann, S., Schaefer, M. R., Schnapp, G., & de Lange, T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1659-1668.2000 · Cited by 768 · see citing works
Short telomeres on human chromosome 17p
Martens, U. M., Zijlmans, J. M. J. M., Poon, S. S. S., Dragowska, W., Yui, J., Chavez, E. A., Ward, R. K., & Lansdorp, P. M. (1998) · Nature Genetics · doi:10.1038/ng0198-018 · Cited by 393 · see citing works
Coquelle, A., Pipiras, E., Toledo, F., Buttin, G., & Debatisse, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80201-9 · Cited by 390 · see citing works
Telomere dynamics in an immortal human cell line.
Murnane, J. P., Sabatier, L., Marder, B. A., & Morgan, W. F. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06822.x · Cited by 381 · see citing works
Accelerated telomere shortening in ataxia telangiectasia
Metcalfe, J. A., Parkhill, J., Campbell, L. J., Stacey, M. W., Biggs, P., Byrd, P. J., & Taylor, A. M. R. (1996) · Nature Genetics · doi:10.1038/ng0796-350 · Cited by 338 · see citing works
Activation of telomerase in a human tumor.
de Lange, T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.2882 · Cited by 282 · see citing works
Studies of the molecular mechanisms in the regulation of telomerase activity
Liu, J. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.15.2091 · Cited by 253 · see citing works
Rogan, E. M., Bryan, T. M., Hukku, B., Maclean, K. N., Chang, A. C.-M., Moy, E. L., Englezou, A., Warneford, S., Dalla‐Pozza, L., & Reddel, R. R. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.9.4745 · Cited by 250 · see citing works
Ludérus, M. E. E., van Steensel, B., Chong, L., Sibon, O. C. M., Cremers, F. F. M., & de Lange, T. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.135.4.867 · Cited by 232 · see citing works
Unusual Chromatin in Human Telomeres
Tommerup, H., Dousmanis, A., & de Lange, T. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5777 · Cited by 232 · see citing works
McEachern, M. J., & Blackburn, E. H. (1996) · Genes & Development · doi:10.1101/gad.10.14.1822 · Cited by 224 · see citing works
t‐loops at trypanosome telomeres
Muñoz‐Jordán, J. L., Cross, G., de Lange, T., & Griffith, J. D. (2001) · The EMBO Journal · doi:10.1093/emboj/20.3.579 · Cited by 220 · see citing works
Smith, S. H., & de Lange, T. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.21.3649 · Cited by 200 · see citing works
Stringent sequence requirements for the formation of human telomeres.
Hanish, J., Yanowitz, J. L., & de Lange, T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8861 · Cited by 192 · see citing works
Baumann, P., Podell, E. R., & Cech, T. R. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.22.8079-8087.2002 · Cited by 164 · see citing works
Broccoli, D., Godley, L. A., Donehower, L. A., Varmus, H. E., & de Lange, T. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3765 · Cited by 157 · see citing works
Telomeres, interstitial telomeric repeat sequences, and chromosomal aberrations
Bolzán, A. D., & de Bianchi, M. S. A. (2006) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2005.12.003 · Cited by 149 · see citing works
UbcD1, a Drosophila ubiquitin-conjugating enzyme required for proper telomere behavior.Preprint
Cenci, G., Rawson, R. B., Belloni, G., Castrillón, D. H., Tudor, M., Petrucci, R., Goldberg, M. L., Wasserman, S. A., & Gatti, M. (1997) · Genes & Development · doi:10.1101/gad.11.7.863 · Cited by 124 · see citing works
Telomere length, chromatin structure and chromosome fusigenic potential
Slijepčević, P., Hande, M. P., Bouffler, S. D., Lansdorp, P. M., & Bryant, P. E. (1997) · Chromosoma · doi:10.1007/s004120050263 · Cited by 96 · see citing works
Telomeres and telomerase: more than the end of the line
Pardue, M. L., & DeBaryshe, P. G. (1999) · Chromosoma · doi:10.1007/s004120050354 · Cited by 93 · see citing works
Toledo, F., Buttin, G., & Debatisse, M. (1993) · Current Biology · doi:10.1016/0960-9822(93)90175-n · Cited by 79 · see citing works
Chromosomal aberrations involving telomeres and interstitial telomeric sequences
Bolzán, A. D. (2011) · Mutagenesis · doi:10.1093/mutage/ger052 · Cited by 77 · see citing works
Diet-related telomere shortening and chromosome stability
Marcon, F., Siniscalchi, E., Crebelli, R., Saieva, C., Sera, F., Fortini, P., Simonelli, V., & Palli, D. (2011) · Mutagenesis · doi:10.1093/mutage/ger056 · Cited by 71 · see citing works
Telomere content correlates with stage and prognosis in breast cancer
Fordyce, C., Heaphy, C. M., Bisoffi, M., Wyaco, J. L., Joste, N. E., Mangalik, A., Baumgartner, K. B., Baumgartner, R., Hunt, W. C., & Griffith, J. K. (2006) · Breast Cancer Research and Treatment · doi:10.1007/s10549-006-9204-1 · Cited by 69 · see citing works
Zhang, S.-J., Zeng, X., Zhang, P., Toomey, N., Chuang, R.-Y., Chang, L., & Lee, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.14.7988 · Cited by 69 · see citing works
Role of induced genetic instability in the mutagenic effects of chemicals and radiation
Murname, J. P. (1996) · Mutation Research/Genetic Toxicology · doi:10.1016/s0165-1218(96)90017-8 · Cited by 68 · see citing works
Dhar, S., Squire, J. A., Hande, M. P., Wellinger, R. J., & Pandita, T. K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.20.7764-7772.2000 · Cited by 67 · see citing works
The involvement of telomeric sequences in chromosomal aberrations
Bouffler, S. D., Morgan, W. F., Pandita, T. K., & Slijepčević, P. (1996) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/s0165-1110(96)90033-0 · Cited by 66 · see citing works
Reduced telomere length in ataxia-telangiectasia fibroblasts
Xia, S. J., Shammas, M. A., & Reis, R. J. S. (1996) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(96)00015-8 · Cited by 62 · see citing works
Preclinical and clinical strategies for development of telomerase and telomere inhibitors
Sharma, S., Raymond, É., Soda, H., Sun, D., Hilsenbeck, S., Sharma, A., Izbicka, E., Windle, B. E., & Hoff, D. D. V. (1997) · Annals of Oncology · doi:10.1023/a:1008206420505 · Cited by 59 · see citing works
Centromere fission, not telomere erosion, triggers chromosomal instability in human carcinomas
Martínez‐A, C., & van Wely, K. H. M. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr069 · Cited by 46 · see citing works
Absence or low number of telomere repeats at junctions of dicentric chromosomes
Wan, T. S. K., Martens, U. M., Poon, S. S. S., Tsao, S., Ha, S., & Lansdorp, P. M. (1999) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199901)24:1 · Cited by 45 · see citing works
JTB: A novel membrane protein gene at 1q21 rearranged in a jumping translocation
Hatakeyama, S., Osawa, M., Omine, M., & Ishikawa, F. (1999) · Oncogene · doi:10.1038/sj.onc.1202510 · Cited by 46 · see citing works
Shortened Telomeres Involved in a Case With a Jumping Translocation at 1q21
Hatakeyama, S., Fujita, K., Mori, H., Omine, M., & Ishikawa, F. (1998) · Blood · doi:10.1182/blood.v91.5.1514 · Cited by 44 · see citing works
Telomeric sequences, radiation sensitivity and genomic instability
Bouffler, S. D., Blasco, M. A., Cox, R., & Smith, P. J. (2001) · International Journal of Radiation Biology · doi:10.1080/09553000110069326 · Cited by 43 · see citing works
Expression of p21 predicts PSA failure in locally advanced prostate cancer treated by prostatectomy
Lacombe, L., Maillette, A., Meyer, F., Veilleux, C., Moore, L., & Fradet, Y. (2001) · International Journal of Cancer · doi:10.1002/1097-0215(20010520)95:3 · Cited by 35 · see citing works
DNA Polymerase β Interacts with TRF2 and Induces Telomere Dysfunction in a Murine Mammary Cell Line
Fotiadou, P. P., Henegariu, O., & Sweasy, J. B. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0136 · Cited by 37 · see citing works
McKerlie, M., Lin, S., & Zhu, X. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks035 · Cited by 38 · see citing works
Telomere length variation in normal and malignant human tissues
Schmitt, H., Blin, N., Zankl, H., & Scherthan, H. (1994) · Genes Chromosomes and Cancer · doi:10.1002/gcc.2870110306 · Cited by 38 · see citing works
Telomere instability in a human cancer cell line
Sprung, C. N., Afshar, G., Chavez, E. A., Lansdorp, P. M., Sabatier, L., & Murnane, J. P. (1999) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(99)00115-3 · Cited by 36 · see citing works
Telomere Dynamics in a Human Cancer Cell Line
Sprung, C. N., Sabatier, L., & Murnane, J. P. (1999) · Experimental Cell Research · doi:10.1006/excr.1998.4293 · Cited by 36 · see citing works
Shippen, D. E. (1993) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(05)80095-4 · Cited by 33 · see citing works
MEN1 tumor‐suppressor protein localizes to telomeres during meiosis
Suphapeetiporn, K., Greally, J. M., Walpita, D., Ashley, T., & Bale, A. E. (2002) · Genes Chromosomes and Cancer · doi:10.1002/gcc.10113 · Cited by 29 · see citing works
Wan, T. S. K., Chan, L. C., Ngan, H., & Tsao, S. (1997) · Cancer Genetics and Cytogenetics · doi:10.1016/s0165-4608(96)00245-2 · Cited by 27 · see citing works
Zhang, J., Wang, L., Huang, H., Nelson, M., & Smith, D. I. (2001) · Genes Chromosomes and Cancer · doi:10.1002/1098-2264(2000)9999:9999 · Cited by 66 · see citing works
Involvement of telomeric sequences in chromosomal aberrations
Bouffler, S. D. (1998) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(98)00114-6 · Cited by 25 · see citing works
McKerlie, M., Walker, J. R., Mitchell, T. R. H., Wilson, F. R., & Zhu, X. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt775 · Cited by 23 · see citing works
CSB cooperates with SMARCAL1 to maintain telomere stability in ALT cells
Feng, E., Batenburg, N. L., Walker, J. R., Ho, A., Mitchell, T. R. H., Jian, Q., & Zhu, X. (2020) · Journal of Cell Science · doi:10.1242/jcs.234914 · Cited by 23 · see citing works
Structure of the terminal 300 kb of DNA from human chromosome 21q
Reston, J. T., Hu, X.-L., Macina, R. A., Spais, C. M., & Riethman, H. C. (1995) · Genomics · doi:10.1016/0888-7543(95)80079-2 · Cited by 21 · see citing works
Walen, K. H. (2007) · Cell Biology International · doi:10.1016/j.cellbi.2007.06.015 · Cited by 20 · see citing works
Queiroz-Machado, J., Perdigão, J., Simões-Carvalho, P., Herrmann, S., & Sunkel, C. E. (2001) · Chromosoma · doi:10.1007/s004120000116 · Cited by 20 · see citing works
Tanaka, H., Beam, M. J., & Caruana, K. (2014) · Neoplasia · doi:10.1016/j.neo.2014.08.009 · Cited by 19 · see citing works
The ends and the middle: putting chromosomes together
Pardue, M. L. (1994) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(94)90069-8 · Cited by 17 · see citing works
Mitotic and meiotic instability of a telomere association involving the Y chromosome
Huang, B., Martin, C. L., Sandlin, C. J., Wang, S., & Ledbetter, D. H. (2004) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30146 · Cited by 16 · see citing works
Ijarotimi, O. S., Wumi-Adefaye, O. A., Oluwajuyitan, T. D., & Oloniyo, R. O. (2022) · Applied Food Research · doi:10.1016/j.afres.2022.100074 · Cited by 15 · see citing works
Genomic instability demonstrates similarity between DCIS and invasive carcinomas
Heaphy, C. M., Bisoffi, M., Joste, N. E., Baumgartner, K. B., Baumgartner, R., & Griffith, J. K. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-008-0165-4 · Cited by 15 · see citing works
Finnon, P., Wong, H.-P., Silver, A. R., Slijepčević, P., & Bouffler, S. D. (2001) · International Journal of Radiation Biology · doi:10.1080/09553000110075220 · Cited by 15 · see citing works
Rogalla, P., Kazmierczak, B., Rohen, C., Trams, G., Bartnitzke, S., & Bullerdiek, J. (1994) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(94)90143-0 · Cited by 15 · see citing works
Telomeric length in individuals and cell lines with altered p53 status
Kruk, P. A., & Bohr, V. A. (1999) · Radiation Oncology Investigations · doi:10.1002/(sici)1520-6823(1999)7:1 · Cited by 14 · see citing works
Peitl, P. (2002) · Mutagenesis · doi:10.1093/mutage/17.1.67 · Cited by 13 · see citing works
Differential transactivation by the androgen receptor in prostate cancer cells
Snoek, R., Bruchovsky, N., Kasper, S., Matusik, R. J., Gleave, M. E., Sato, N., Mawji, N. R., & Rennie, P. S. (1998) · The Prostate · doi:10.1002/(sici)1097-0045(19980901)36:4 · Cited by 50 · see citing works
DNA-Directed Polymerase Subunits Play a Vital Role in Human Telomeric Overhang Processing
Diotti, R., Kalan, S., Matveyenko, A., & Loayza, D. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0381 · Cited by 11 · see citing works
Kokkola, A., Monni, O. M., Puolakkainen, P. A., Larramendy, M. L., Victorzon, M., Nordling, S., Haapiainen, R. K., Kivilaakso, E. O., & Knuutila, S. (1997) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199709)20:1 · Cited by 100 · see citing works
Furuya, T., Morgan, R., Berger, C. S., & Sandberg, A. A. (1993) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(93)90183-m · Cited by 11 · see citing works
Self-citationTelomeric association in women with breast and uterine cervix cancer
Paz‐y‐Miño, C., Sánchez, M. E., Pozo, M. D., Baldéon, M. A., Córdova, A., Gutiérrez, S., Peñaherrera, M. S., Neira, M., Ocampo, L., & Leone, P. (1997) · Cancer Genetics and Cytogenetics · doi:10.1016/s0165-4608(96)00420-7 · Cited by 10 · see citing works
Chromosome-specific telomeric associations in Chinese hamster embryonic cells
Slijepčević, P., Xiao, Y., & Natarajan, A. T. (2000) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(200005)28:1 · Cited by 8 · see citing works
7 The Proterminal Regions and Telomeres of Human Chromosomes
Royle, N. J. (1995) · Advances in genetics · doi:10.1016/s0065-2660(08)60207-2 · Cited by 8 · see citing works
Zhang, L., Cooley, L. D., Chandratre, S. R., Ahmed, A. A., & Jacobson, J. D. (2013) · Case Reports in Endocrinology · doi:10.1155/2013/747898 · Cited by 7 · see citing works
RetractedKrishnaja, A. P., & Sharma, N. K. (2006) · International Journal of Radiation Biology · doi:10.1080/09553000600774097 · Cited by 5 · see citing works
Chai, K. X. Y., Lee, E. C. Y., Li, Z., Muhammad, N. A. B., Lim, J. Q., Huang, D., Lim, S. T., Chan, J. Y., & Ong, C. K. (2025) · Human Cell · doi:10.1007/s13577-025-01264-1 · Cited by 2 · see citing works
Telomeres, DNA Repair Proteins, and Making Ends Meet
Bailey, S. M., Meyne, J., & Goodwin, E. H. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-095-7_14 · Cited by 4 · see citing works
Telomeres and Replicative Senescence
Allsopp, R., Wang, S., Kim, N., & Harley, C. B. (1998) · CRC Press eBooks · doi:10.1201/b14256-24 · Cited by 1 · see citing works
Telomeres and Cell Division in Drosophila melanogaster
Cenci, G., & Gatti, M. (1997) · Springer eBooks · doi:10.1007/978-1-4615-5365-6_1
Characterization of homologous recombination proteins in telomere processing and t-circle formation
Stockton, P. D. Q. (2009) · eScholarship (California Digital Library)
Karyotypic Variability in Different Marker-Free Cell Lines
Poljanskaya, G. G., Турилова, В. И., & Yakovleva, T. K. (2025) · Cell and Tissue Biology · doi:10.1134/s1990519x25010031
- Authors
- Saltman, D., Morgan, R., Cleary, M. L., & de Lange, T.
- Affiliations
- Stanford Medicine (US)
- Venue
- Chromosoma
- Published
- 1993-01
- Volume
- 102
- Issue
- 2
- Pages
- 121-128
- ISSN
- 0009-5915 (ISSN-L)
- 1432-0886
- OpenAlex
- W1994528732
- Cited by
- 77
- References
- 53
- Citations by year
- 2025: 2 · 2022: 1 · 2020: 1 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Chromosoma (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (CA 42971)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- telomeres, telomere length, cancer cells, chromosomal instability, telomere structure, telomere fusion
- MeSH terms
- Base Sequence, Chromosome Banding, DNA, Neoplasm, Humans, Karyotyping, Male, Melanoma, Metaphase, Molecular Sequence Data, Repetitive Sequences, Nucleic Acid, Tumor Cells, Cultured, Oligonucleotide Probes, Lymphoma, Large B-Cell, Diffuse, Telomere
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review