Cited by 77Telomeres, Telomerase, and SenescenceChromosomal and Genetic VariationsGenomics and Chromatin Dynamics

Telomeric structure in cells with chromosome end associations

Saltman, David, Morgan, Rodman, Cleary, Michael L., de Lange, Titia·1993·Chromosoma

Abstract

End-to-end associations of metaphase chromosomes have been observed in a variety of human tumors, ageing cells, and several chromosome instability syndromes. Since telomeres of tumor cells and ageing tissues are often reduced in length, it has been suggested that chromosome end associations may be due to loss of telomeric repeats. We report the molecular structure of telomeres of two human tumor cell lines with frequent end-to-end associations of metaphase chromosomes. These telomeres were shown to be severely reduced compared with most other human cells with functional telomeres. However, we also describe two cell lines with severely shortened telomeres that are not detectably compromised in their function. We suggest that telomeric length is not the only determinant of the fusigenic behavior of human telomeres in tumor cells.

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Crossref · 10.1007/bf00356029

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  • HeLall has shorter telomeres ranging from 3 to 6.5 kb (6 kb median).

    “HeLal.2.11 has telomeres of approximately 15 to 40 kb (21), whereas HeLall has shorter telomeres ranging from 3 to 6.5 kb (6 kb median) (39).”

    From Control of Human Telomere Length by TRF1 and TRF2 (2000) · cites this paper as [39]

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Authors
Saltman, D., Morgan, R., Cleary, M. L., & de Lange, T.
Affiliations
Stanford Medicine (US)
Venue
Chromosoma
Published
1993-01
Volume
102
Issue
2
Pages
121-128
ISSN
  • 0009-5915 (ISSN-L)
  • 1432-0886
OpenAlex
W1994528732
Cited by
77
References
53
Citations by year
2025: 2 · 2022: 1 · 2020: 1 · 2014: 2 · 2013: 2 · 2012: 1
FWCI
4.66
Type
journal article
Language
en
Open access
closed
Locations
  • Chromosoma (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (CA 42971)
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
telomeres, telomere length, cancer cells, chromosomal instability, telomere structure, telomere fusion
MeSH terms
Base Sequence, Chromosome Banding, DNA, Neoplasm, Humans, Karyotyping, Male, Melanoma, Metaphase, Molecular Sequence Data, Repetitive Sequences, Nucleic Acid, Tumor Cells, Cultured, Oligonucleotide Probes, Lymphoma, Large B-Cell, Diffuse, Telomere

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