Variability at the Telomeres of the Human X/Y Pseudoautosomal Region

Cooke, H.J.; Smith, B.A.

doi:10.1101/sqb.1986.051.01.026

PreprintCited by 233Telomeres, Telomerase, and SenescenceChromosomal and Genetic VariationsGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Variability at the Telomeres of the Human X/Y Pseudoautosomal Region

Cooke, H.J., Smith, B.A.·1986·Cold Spring Harbor Symposia on Quantitative Biology

DOI 10.1101/sqb.1986.051.01.026

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Abstract

It has been evident for some time that the telomeres (ends) of eukaryotic hromosomes must have proper-ties that fulfill a number of functional requirements. For example, unlike ends of chromosome fragments, telomeres protect he natural chromosome end against fusion with other chromosome ends. They are often associated with the nuclear envelope. They pose a rep-lication problem for the cell since all known DNA po-lymerases require a primer and synthesize only in the 5'--'3 ' direction. This implies that without a special structure, only one daughter chromosome would be completely replicated, the other being shortened, com-pared with the parental chromosome, by excision of a primer. This hortening would occur at each cell divi-sion and could presumably not be tolerated beyond a

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Telomere length determines how many divisions a cell can undergo before senescence.
“Indeed, it has been proposed that telomere length speci®es the number of cell divisions a cell can undergo prior to senescence (Cooke and Smith, 1986;Harley, 1991).”
From A highly selective telomerase inhibitor limiting human cancer cell proliferation (2001) · cites this paper as Cooke and Smith, 1986

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Authors: Cooke, H. J., & Smith, B. A.
ORCID: Cooke, H.J.
Smith, B.A.
Venue: Cold Spring Harbor Symposia on Quantitative Biology
Publisher: Cold Spring Harbor Laboratory
Published: 1986-01-01
Volume: 51
Issue: 0
Pages: 213-219
ISSN: 0091-7451 (ISSN-L)
1943-4456
DOI: 10.1101/sqb.1986.051.01.026
OpenAlex: W2333982890
Cited by: 233
References: 0
Citations by year: 2025: 3 · 2024: 6 · 2023: 1 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 6 · 2015: 1 · 2014: 4 · 2013: 5 · 2012: 5
Type: posted content
Language: en
Open access: closed
Locations: Cold Spring Harbor Symposia on Quantitative Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Keywords: telomeres, pseudoautosomal region, chromosome end protection, chromosome fusion, DNA replication, telomere shortening, nuclear envelope
MeSH terms: Cell Line, DNA Restriction Enzymes, Humans, Male, Repetitive Sequences, Nucleic Acid, Saccharomyces cerevisiae, Genetic Variation, X Chromosome, Y Chromosome

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Variability at the Telomeres of the Human X/Y Pseudoautosomal Region

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